(Q36816026)

16 August 2017

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title

Global metabolic profiling and its role in systems biology to advance personalized medicine in the 21st century (English)

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16 August 2017

main subject

personalized medicine

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Laura K Schnackenberg

series ordinal

1

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16 August 2017

publication date

1 May 2007

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Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare

16 August 2017

published in

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16 August 2017

volume

7

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16 August 2017

issue

3

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16 August 2017

page(s)

247-259

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Systems biology: a brief overview

16 August 2017

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'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

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Gut microorganisms, mammalian metabolism and personalized health care

21 January 2018

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21 January 2018

NMR-based metabolomics

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Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis

21 January 2018

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Proton nuclear magnetic resonance spectroscopy of body fluids in the field of inborn errors of metabolism.

21 January 2018

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Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis

21 January 2018

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NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition

21 January 2018

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The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements

21 January 2018

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The application of NMR-based metabonomics in neurological disorders

21 January 2018

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Metabolomic study of cisplatin-induced nephrotoxicity.

21 January 2018

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An integrated study of acute effects of valproic acid in the liver using metabonomics, proteomics, and transcriptomics platforms.

21 January 2018

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High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies.

21 January 2018

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Analytical reproducibility in (1)H NMR-based metabonomic urinalysis

21 January 2018

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An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy

21 January 2018

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Cellular environment of metabolites and a metabonomic study of tamoxifen in endometrial cells using gradient high resolution magic angle spinning 1H NMR spectroscopy

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabolic assessment of human liver transplants from biopsy samples at the donor and recipient stages using high-resolution magic angle spinning 1H NMR spectroscopy

21 January 2018

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Integrated metabonomic analysis of the multiorgan effects of hydrazine toxicity in the rat.

21 January 2018

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Biochemical characterization of rat intestine development using high-resolution magic-angle-spinning 1H NMR spectroscopy and multivariate data analysis

21 January 2018

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Metabonomics in toxicology: a review

21 January 2018

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Analytical strategies in metabonomics

21 January 2018

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A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabonomics with 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamicin-induced nephrotoxicity in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Monitoring diet effects via biofluids and their implications for metabolomics studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Molecular profiling approaches for identifying novel biomarkers

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabonomic modeling of drug toxicity

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Classification of toxin-induced changes in 1H NMR spectra of urine using an artificial neural network.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

1H NMR Pattern Recognition and 31P NMR Studies with d-Serine in Rat Urine and Kidney, Time- and Dose-Related Metabolic Effects

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Cyclosporin A-induced changes in endogenous metabolites in rat urine: a metabonomic investigation using high field 1H NMR spectroscopy, HPLC-TOF/MS and chemometrics

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

A metabonomic investigation of the biochemical effects of mercuric chloride in the rat using 1H NMR and HPLC-TOF/MS: time dependent changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabonomics in pharmaceutical discovery and development.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabolic biomarker and kinase drug target discovery in cancer using stable isotope-based dynamic metabolic profiling (SIDMAP).

21 January 2018

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[1,2-13C2]-D-glucose profiles of the serum, liver, pancreas, and DMBA-induced pancreatic tumors of rats

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Detection of epithelial ovarian cancer using 1H-NMR-based metabonomics

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Gas chromatographic-mass spectrometric urinary metabolome analysis to study mutations of inborn errors of metabolism

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabonomic assessment of vasculitis in rats.

21 January 2018

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Vascular proteomics: linking proteomic and metabolomic changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

PNU-91325 increases fatty acid synthesis from glucose and mitochondrial long chain fatty acid degradation: a comparative tracer-based metabolomics study with rosiglitazone and pioglitazone in HepG2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

A Linear Steady-State Treatment of Enzymatic Chains. Critique of the Crossover Theorem and a General Procedure to Identify Interaction Sites with an Effector

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabolic control analysis in drug discovery and disease

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabolic control in integrated biochemical systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

From genomes to systems: the path with yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabolomics and systems biology: making sense of the soup

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

The role of analytical sciences in medical systems biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

What do mitochondrial diseases teach us about normal mitochondrial functions...that we already knew: threshold expression of mitochondrial defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

How aneuploidy affects metabolic control and causes cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabolomics by numbers: acquiring and understanding global metabolite data

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Integrating gene expression and metabolic profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Advancing drug discovery through systems biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Systems biology in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Techniques: application of systems biology to absorption, distribution, metabolism, excretion and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

The agony and ecstasy of "OMIC" technologies in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Towards quantitative biology: integration of biological information to elucidate disease pathways and to guide drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Computational systems biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Development of human protein reference database as an initial platform for approaching systems biology in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

ArrayTrack--supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Integration of metabolic networks and gene expression in virtual reality

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

A novel method for visualizing nuclear hormone receptor networks relevant to drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Algorithms for network analysis in systems-ADME/Tox using the MetaCore and MetaDrug platforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

CYCLONET--an integrated database on cell cycle regulation and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Integrative biological analysis of the APOE*3-leiden transgenic mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Combination of 'omics' data to investigate the mechanism(s) of hydrazine-induced hepatotoxicity in rats and to identify potential biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Monitoring the health to disease continuum with global metabolic profiling and systems biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Pharmaco-metabonomic phenotyping and personalized drug treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

A 1H NMR-based metabonomic study of urine and plasma samples obtained from healthy human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Impact of analytical bias in metabonomic studies of human blood serum and plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

OMICS-driven biomarker discovery in nutrition and health

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

HMDB: the Human Metabolome Database

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Minimum information about a microarray experiment (MIAME)-toward standards for microarray data

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

The need for guidelines in publication of peptide and protein identification data: Working Group on Publication Guidelines for Peptide and Protein Identification Data

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Phenotype characterisation using integrated gene transcript, protein and metabolite profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Metabolomics: Current analytical platforms and methodologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Plant metabolomics: the missing link in functional genomics strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Earthworm species of the genus Eisenia can be phenotypically differentiated by metabolic profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Assessment of Analytical Reproducibility of1H NMR Spectroscopy Based Metabonomics for Large-Scale Epidemiological Research: the INTERMAP Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

NMR-based metabonomic toxicity classification: hierarchical cluster analysis and k-nearest-neighbour approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

Toxicity classification from metabonomic data using a density superposition approach: ‘CLOUDS’

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737159.7.3.247

21 January 2018

Identifiers

DOI

10.1586/14737159.7.3.247

1 reference

16 August 2017

1 reference