(Q36827835)

16 August 2017

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title

Mechanisms of disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology (English)

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16 August 2017

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Jonathan R Seckl

1

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16 August 2017

Megan C Holmes

series ordinal

2

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16 August 2017

publication date

1 June 2007

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Nature Clinical Practice Endocrinology and Metabolism

16 August 2017

published in

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16 August 2017

volume

3

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16 August 2017

issue

6

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16 August 2017

page(s)

479-488

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The developmental origins of adult disease

16 August 2017

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Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations

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The programming of individual differences in defensive responses and reproductive strategies in the rat through variations in maternal care

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7 January 2021

Living with the past: evolution, development, and patterns of disease

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7 January 2021

Transgenerational induction of defences in animals and plants

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7 January 2021

Concentrations of corticotrophin-releasing hormone in the umbilical-cord blood of pregnancies complicated by pre-eclampsia

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7 January 2021

Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis.

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Fetal nutrition and cardiovascular disease in adult life

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Sex Steroid Induced Changes in Hepatic Enzymes

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7 January 2021

Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension?

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7 January 2021

Prenatal glucocorticoids and long-term programming

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7 January 2021

Glucocorticoid exposure in utero: new model for adult hypertension

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7 January 2021

Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring.

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7 January 2021

Maternal glucocorticoid treatment programs HPA regulation in adult offspring: sex-specific effects

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7 January 2021

Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology

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7 January 2021

Maternal asthma as a model for examining fetal sex-specific effects on maternal physiology and placental mechanisms that regulate human fetal growth.

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7 January 2021

Prenatal dexamethasone causes oligonephronia, sodium retention, and higher blood pressure in the offspring

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7 January 2021

Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure

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7 January 2021

Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase

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7 January 2021

Inhibition of 11β-Hydroxysteroid Dehydrogenase in Pregnant Rats and the Programming of Blood Pressure in the Offspring

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7 January 2021

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7 January 2021

Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring

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7 January 2021

The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids.

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7 January 2021

Gene structure and chromosomal localization of the human HSD11K gene encoding the kidney (type 2) isozyme of 11 beta-hydroxysteroid dehydrogenase

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7 January 2021

Oxygen regulation of placental 11 beta-hydroxysteroid dehydrogenase 2: physiological and pathological implications

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7 January 2021

The effects of chorioamnionitis and betamethasone on 11beta hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta

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7 January 2021

Glucocorticoids stimulate the expression of 11beta-hydroxysteroid dehydrogenase type 2 in cultured human placental trophoblast cells

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7 January 2021

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7 January 2021

Cadmium reduces 11 beta-hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells

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7 January 2021

Organotins disrupt the 11beta-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoids

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7 January 2021

Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat

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7 January 2021

Alterations in placental 11 beta-hydroxysteroid dehydrogenase (11 betaHSD) activities and fetal cortisol:cortisone ratios induced by nutritional restriction prior to conception and at defined stages of gestation in ewes.

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7 January 2021

Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation

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7 January 2021

Neonatal leptin treatment reverses developmental programming

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7 January 2021

Glucocorticoid regulation of human and ovine parturition: the relationship between fetal hypothalamic-pituitary-adrenal axis activation and intrauterine prostaglandin production

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https://api.crossref.org/works/10.1038%2FNCPENDMET0515

7 January 2021

Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of human labor

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7 January 2021

Enhancement of glucocorticoid-induced 11beta-hydroxysteroid dehydrogenase type 1 expression by proinflammatory cytokines in cultured human amnion fibroblasts

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7 January 2021

Type 2 11 beta-hydroxysteroid dehydrogenase in foetal and adult life

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7 January 2021

Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress

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7 January 2021

Epigenetic programming by maternal behavior

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7 January 2021

Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2.

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7 January 2021

The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk

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7 January 2021

Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission

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7 January 2021

Prenatal programming of hepatocyte nuclear factor 4alpha in the rat: A key mechanism in the 'foetal origins of hyperglycaemia'?

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7 January 2021

Glucocorticoid-induced DNA demethylation and gene memory during development

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7 January 2021

Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children

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7 January 2021

Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial

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7 January 2021

Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: results of a pilot study

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7 January 2021

Repeated antenatal corticosteroids: size at birth and subsequent development

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7 January 2021

Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity

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https://api.crossref.org/works/10.1038%2FNCPENDMET0515

7 January 2021

Neonatal respiratory distress syndrome after repeat exposure to antenatal corticosteroids: a randomised controlled trial.

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https://api.crossref.org/works/10.1038%2FNCPENDMET0515

7 January 2021

Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic-pituitary-adrenal axis function

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0515

7 January 2021

Size at birth and adrenocortical function in childhood

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0515

7 January 2021

Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0515

7 January 2021

Post-traumatic stress disorder

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0515

7 January 2021

Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0515

7 January 2021

Transgenerational effects of posttraumatic stress disorder in babies of mothers exposed to the World Trade Center attacks during pregnancy

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0515

7 January 2021

The World Trade Center disaster and intrauterine growth restriction

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0515

7 January 2021

Psychological trauma associated with the World Trade Center attacks and its effect on pregnancy outcome

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0515

7 January 2021

Identifiers

DOI

10.1038/NCPENDMET0515

1 reference

16 August 2017

1 reference