(Q36828580)

16 August 2017

Total synthesis of TMC-95A and -B via a new reaction leading to Z-enamides. Some preliminary findings as to SAR (English)

1 reference

16 August 2017

Songnian Lin

1

1 reference

16 August 2017

Zhi-Qiang Yang

2

1 reference

16 August 2017

Benjamin H B Kwok

3

1 reference

16 August 2017

Michael Koldobskiy

4

1 reference

16 August 2017

Craig M Crews

5

1 reference

16 August 2017

Samuel J Danishefsky

6

1 reference

16 August 2017

language of work or name

English

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publication date

1 May 2004

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Journal of the American Chemical Society

16 August 2017

1 reference

16 August 2017

126

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16 August 2017

20

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16 August 2017

6347-6355

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Simplified synthetic TMC-95A/B analogues retain the potency of proteasome inhibitory activity

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507741

Proteasome inhibitors: from research tools to drug candidates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507741

Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507741

The ubiquitin-proteasome pathway and proteasome inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507741

The ubiquitin-proteasome pathway: on protein death and cell life

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507741

Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507741

Structure and functions of the 20S and 26S proteasomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507741

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507741

Mechanism of cis-Enamide Formation from N-(α-Silyl)allyl Amides: Synthetic Potential of Stepwise Dyotropic Rearrangements

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507741

The total synthesis of proteasome inhibitors TMC-95A and TMC-95B: discovery of a new method to generate cis-propenyl amides

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507741

Not just research tools--proteasome inhibitors offer therapeutic promise

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507741

Stereocontrolled synthesis of the northern part of potent proteasome inhibitor TMC-95A.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507741

TMC-95A, B, C, and D, novel proteasome inhibitors produced by Apiospora montagnei Sacc. TC 1093. Taxonomy, production, isolation, and biological activities

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2507741

Synthesis of the Functionalized Macrocyclic Core of Proteasome Inhibitors TMC-95A and B This work was supported by grants from the National Institutes of Health (grant CA28824). We thank Dr. George Sukenick and Sylvi Rusli of the MSKCC NMR Core Faci

5 September 2018

1 reference

12 December 2020

Structures of TMC-95A-D: novel proteasome inhibitors from Apiospora montagnei sacc. TC 1093

1 reference

12 December 2020

Efficient synthesis of novel 3-(Het)arylanthranilic acids via a suzuki cross-coupling reaction of 7-iodoisatin with (Het)arylboronic acids in water

1 reference

12 December 2020

A concise formal total synthesis of TMC-95A/B proteasome inhibitors

1 reference

12 December 2020

Total synthesis of TMC-95A

1 reference

12 December 2020

Synthesis of enamides related to the salicylate antitumor macrolides using copper-mediated vinylic substitution

1 reference

12 December 2020

Identifiers

DOI

10.1021/JA049821K

1 reference

16 August 2017

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16 August 2017

PubMed publication ID

15149232

1 reference