(Q36834148)

16 August 2017

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title

Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase (English)

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16 August 2017

Sangita Singh

1

1 reference

PubMed ID

17534535

16 August 2017

Peter Madzelan

series ordinal

2

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PubMed ID

17534535

16 August 2017

Ruma Banerjee

series ordinal

3

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16 August 2017

12 March 2007

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16 August 2017

Natural Product Reports

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16 August 2017

24

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16 August 2017

3

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16 August 2017

631-639

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Cystathionine beta-synthase: structure, function, regulation, and location of homocystinuria-causing mutations

16 August 2017

1 reference

Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein

21 January 2018

1 reference

The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes

21 January 2018

1 reference

Cystathionine beta-synthase mutations in homocystinuria

21 January 2018

1 reference

Homocysteine metabolism in pregnancies complicated by neural-tube defects.

21 January 2018

1 reference

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

21 January 2018

1 reference

Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease.

21 January 2018

1 reference

Yeast cystathionine beta-synthase is a pyridoxal phosphate enzyme but, unlike the human enzyme, is not a heme protein

21 January 2018

1 reference

Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan hemoflagellate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma

21 January 2018

1 reference

Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein

21 January 2018

1 reference

Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme

21 January 2018

1 reference

Effects of heme ligand mutations including a pathogenic variant, H65R, on the properties of human cystathionine beta-synthase

21 January 2018

1 reference

Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme

21 January 2018

1 reference

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

21 January 2018

1 reference

The structure of a domain common to archaebacteria and the homocystinuria disease protein

21 January 2018

1 reference

Mapping peptides correlated with transmission of intrasteric inhibition and allosteric activation in human cystathionine beta-synthase

21 January 2018

1 reference

S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity

21 January 2018

1 reference

Heme-based sensors: defining characteristics, recent developments, and regulatory hypotheses

21 January 2018

1 reference

Mechanisms of ligand discrimination by heme proteins

21 January 2018

1 reference

Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzyme

21 January 2018

1 reference

Dynamics of carbon monoxide binding to cystathionine beta-synthase

21 January 2018

1 reference

Resonance Raman characterization of the heme cofactor in cystathionine beta-synthase. Identification of the Fe-S(Cys) vibration in the six-coordinate low-spin heme

21 January 2018

1 reference

Novel heme ligation in a c-type cytochrome involved in thiosulfate oxidation: EPR and MCD of SoxAX from Rhodovulum sulfidophilum

21 January 2018

1 reference

Mercuric chloride-induced spin or ligation state changes in ferric or ferrous human cystathionine beta-synthase inhibit enzyme activity

21 January 2018

1 reference

The redox behavior of the heme in cystathionine beta-synthase is sensitive to pH.

21 January 2018

1 reference

The heme of cystathionine beta-synthase likely undergoes a thermally induced redox-mediated ligand switch

21 January 2018

1 reference

Neutral thiol as a proximal ligand to ferrous heme iron: implications for heme proteins that lose cysteine thiolate ligation on reduction

21 January 2018

1 reference

Structure of the CO sensing transcription activator CooA

21 January 2018

1 reference

Characterization of a direct oxygen sensor heme protein from Escherichia coli. Effects of the heme redox states and mutations at the heme-binding site on catalysis and structure.

21 January 2018

1 reference

A Redox-controlled Molecular Switch Revealed by the Crystal Structure of a Bacterial Heme PAS Sensor

21 January 2018

1 reference

Dynamics of carbon monoxide binding to CooA.

21 January 2018

1 reference

Coordination chemistry of the heme in cystathionine beta-synthase: formation of iron(II)-isonitrile complexes

21 January 2018

1 reference

Solvent-accessible cysteines in human cystathionine beta-synthase: crucial role of cysteine 431 in S-adenosyl-L-methionine binding

21 January 2018

1 reference

Redox properties and coordination structure of the heme in the co-sensing transcriptional activator CooA.

21 January 2018

1 reference

Oxidation-reduction potential measurements on chloroperoxidase and its complexes

21 January 2018

1 reference

Plasma homocysteine as a risk factor for dementia and Alzheimer's disease

21 January 2018

1 reference

Homocysteine and dementia

21 January 2018

1 reference

Homocysteine and redox signaling

21 January 2018

1 reference

Tumor necrosis factor-alpha-induced targeted proteolysis of cystathionine beta-synthase modulates redox homeostasis

21 January 2018

1 reference

Redox regulation of homocysteine-dependent glutathione synthesis

21 January 2018

1 reference

Visualization of PLP-bound intermediates in hemeless variants of human cystathionine beta-synthase: evidence that lysine 119 is a general base

21 January 2018

1 reference

Structure-based mechanism of O2 sensing and ligand discrimination by the FixL heme domain of Bradyrhizobium japonicum

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1039/B604182P

1 reference

16 August 2017

1 reference

PubMed ID

17534535