(Q36841516)

16 August 2017

1 reference

title

Toll-like receptors impact on safety and efficacy of gene transfer vectors (English)

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16 August 2017

0 references

Scott E Hensley

1

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16 August 2017

Andrea Amalfitano

series ordinal

2

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16 August 2017

publication date

5 June 2007

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16 August 2017

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16 August 2017

volume

15

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16 August 2017

issue

8

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16 August 2017

page(s)

1417-1422

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The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

16 August 2017

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7 January 2021

Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2

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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

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7 January 2021

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

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7 January 2021

Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite

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7 January 2021

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

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7 January 2021

Murine retroviruses activate B cells via interaction with toll-like receptor 4

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7 January 2021

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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7 January 2021

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

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7 January 2021

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

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7 January 2021

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

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7 January 2021

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

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7 January 2021

Recognition of single-stranded RNA viruses by Toll-like receptor 7

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7 January 2021

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

A Toll-like receptor recognizes bacterial DNA

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

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7 January 2021

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.

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7 January 2021

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

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7 January 2021

Subcellular localization of Toll-like receptor 3 in human dendritic cells

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7 January 2021

A toll-like receptor that prevents infection by uropathogenic bacteria

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7 January 2021

Toll-like receptor control of the adaptive immune responses

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7 January 2021

Unresponsiveness of MyD88-deficient mice to endotoxin

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7 January 2021

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

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7 January 2021

Endotoxin-induced maturation of MyD88-deficient dendritic cells

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7 January 2021

The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets

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7 January 2021

Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

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7 January 2021

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

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7 January 2021

Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo

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7 January 2021

Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages

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7 January 2021

Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors

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7 January 2021

The role of capsid-endothelial interactions in the innate immune response to adenovirus vectors

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Adenovirus vector-induced inflammation: capsid-dependent induction of the C-C chemokine RANTES requires NF-kappa B.

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Toxicity of a first-generation adenoviral vector in rhesus macaques

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Dendritic cell maturation, but not CD8+ T cell induction, is dependent on type I IFN signaling during vaccination with adenovirus vectors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Replication-deficient adenovirus induces expression of interleukin-8 by airway epithelial cells in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Molecular basis of the inflammatory response to adenovirus vectors

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7 January 2021

Activation of p38 and ERK signaling during adenovirus vector cell entry lead to expression of the C-X-C chemokine IP-10.

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7 January 2021

Recombinant adenovirus induces maturation of dendritic cells via an NF-kappaB-dependent pathway

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7 January 2021

Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Preferential activation of Toll-like receptor nine by CD46-utilizing adenoviruses

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https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Adenovirus efficiently transduces plasmacytoid dendritic cells resulting in TLR9-dependent maturation and IFN-alpha production

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Adenoviral infection induces a multi-faceted innate cellular immune response that is mediated by the toll-like receptor pathway in A549 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Toll-like receptor 9 triggers an innate immune response to helper-dependent adenoviral vectors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Adenovirus hexon protein is a potent adjuvant for activation of a cellular immune response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

The maturation of murine dendritic cells induced by human adenovirus is mediated by the fiber knob domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Sensing infection by adenovirus: Toll-like receptor-independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Activation of host antitumoral responses by cationic lipid/DNA complexes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Antitumor activity of cationic lipid complexed with immunostimulatory DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

CpG methylation of a plasmid vector results in extended transgene product expression by circumventing induction of immune responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Non-immunostimulatory nonviral vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Recombinant adeno-associated virus for muscle directed gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Immunity to adeno-associated virus-mediated gene transfer in a random-bred canine model of Duchenne muscular dystrophy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Systemic delivery of genes to striated muscles using adeno-associated viral vectors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Development and characterization of novel empty adenovirus capsids and their impact on cellular gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Role of viral vectors and virion shells in cellular gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Toll-like receptor 4-dependent activation of dendritic cells by a retrovirus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Toll-like receptors: linking innate and adaptive immunity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Toll-like receptors control activation of adaptive immune responses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Control of B-cell responses by Toll-like receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Recombinant adenovirus vectors activate the alternative complement pathway, leading to the binding of human complement protein C3 independent of anti-ad antibodies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300217

7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300217

1 reference

16 August 2017

1 reference