(Q36861514)

16 August 2017

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title

IDO expression in the brain: a double-edged sword (English)

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16 August 2017

Erik Kwidzinski

1

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16 August 2017

Ingo Bechmann

series ordinal

2

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16 August 2017

publication date

27 June 2007

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Journal of Molecular Medicine

16 August 2017

published in

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16 August 2017

volume

85

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16 August 2017

issue

12

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16 August 2017

page(s)

1351-1359

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Human microglia convert l-tryptophan into the neurotoxin quinolinic acid

16 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00109-007-0229-7

A crucial role for tryptophan catabolism at the host/Candida albicans interface.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-007-0229-7

B7/CD28-Dependent CD4+CD25+ Regulatory T Cells Are Essential Components of the Memory-Protective Immunity to Candida albicans

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FS00109-007-0229-7

Self-tolerance in the immune privileged CNS: lessons from the entorhinal cortex lesion model.

21 January 2018

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12 December 2020

Marrying immunotherapy with chemotherapy: why say IDO?

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12 December 2020

Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase

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12 December 2020

The signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide: involvement of p38 mitogen-activated protein kinase and nuclear

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12 December 2020

Tryptophan depletion as a mechanism of gamma interferon-mediated chlamydial persistence

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12 December 2020

CD40 ligation ablates the tolerogenic potential of lymphoid dendritic cells

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12 December 2020

IFN-beta1b induces kynurenine pathway metabolism in human macrophages: potential implications for multiple sclerosis treatment

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12 December 2020

Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice

1 reference

12 December 2020

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

1 reference

12 December 2020

Modulation of tryptophan catabolism by regulatory T cells.

1 reference

12 December 2020

Tumor necrosis factor-alpha and lipopolysaccharide enhance interferon-induced antichlamydial indoleamine dioxygenase activity independently

1 reference

12 December 2020

Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase

1 reference

12 December 2020

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

1 reference

12 December 2020

The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine

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12 December 2020

Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation

1 reference

12 December 2020

IFN-gamma activated indoleamine 2,3-dioxygenase activity in human cells is an antiparasitic and an antibacterial effector mechanism

1 reference

12 December 2020

4-chloro-3-hydroxyanthranilate reduces local quinolinic acid synthesis, improves functional recovery, and preserves white matter after spinal cord injury

1 reference

12 December 2020

Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells.

1 reference

12 December 2020

Kynurenines, Parkinson's disease and other neurodegenerative disorders: preclinical and clinical studies.

1 reference

12 December 2020

The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases

1 reference

12 December 2020

Interferon-induced indoleamine 2,3-dioxygenase activity in human mononuclear phagocytes

1 reference

12 December 2020

An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid.

1 reference

12 December 2020

Frontal cortex indoleamine-2,3-dioxygenase activity is increased in HIV-1-associated dementia

1 reference

12 December 2020

Prevention of allogeneic fetal rejection by tryptophan catabolism

1 reference

12 December 2020

FasL (CD95L, Apo1L) is expressed in the normal rat and human brain: evidence for the existence of an immunological brain barrier

1 reference

12 December 2020

Quinolinic acid in vivo synthesis rates, extracellular concentrations, and intercompartmental distributions in normal and immune-activated brain as determined by multiple-isotope microdialysis.

1 reference

12 December 2020

Tryptophan metabolism and oxidative stress in patients with chronic brain injury

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12 December 2020

Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease

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12 December 2020

Inhibition of experimental asthma by indoleamine 2,3-dioxygenase

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12 December 2020

Regulation of the kynurenine metabolic pathway by interferon-gamma in murine cloned macrophages and microglial cells.

1 reference

12 December 2020

Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis

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12 December 2020

Inhibition of human herpes simplex virus type 2 by interferon gamma and tumor necrosis factor alpha is mediated by indoleamine 2,3-dioxygenase

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12 December 2020

Blood?Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism

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12 December 2020

Quinolinic acid is increased in CSF and associated with mortality after traumatic brain injury in humans.

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12 December 2020

Quinolinic acid accumulation and functional deficits following experimental spinal cord injury

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12 December 2020

Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite

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12 December 2020

Studies of persistent infection by Chlamydia trachomatis serovar K in TPA-differentiated U937 cells and the role of IFN-gamma

1 reference

12 December 2020

Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures

1 reference

12 December 2020

Local expression of indoleamine 2,3-dioxygenase protects engraftment of xenogeneic skin substitute

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12 December 2020

Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

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12 December 2020

Brain virus burden and indoleamine-2,3-dioxygenase expression during lentiviral infection of rhesus monkey are concomitantly lowered by 6-chloro-2',3'-dideoxyguanosine

1 reference

12 December 2020

Interferon-beta affects the tryptophan metabolism in multiple sclerosis patients

1 reference

12 December 2020

Failed central nervous system regeneration: a downside of immune privilege?

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12 December 2020

Inhibition of T cell proliferation by macrophage tryptophan catabolism

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12 December 2020

Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes.

1 reference

12 December 2020

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12 December 2020

Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria

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12 December 2020

Modulation of Quinolinic and Kynurenic Acid Content in the Rat Brain: Effects of Endotoxins and Nicotinylalanine

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12 December 2020

Indoleamine 2,3-dioxygenase serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cells

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12 December 2020

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

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12 December 2020

CTLA-4-Ig regulates tryptophan catabolism in vivo.

1 reference

12 December 2020

Comparison of gamma interferon-mediated antichlamydial defense mechanisms in human and mouse cells

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12 December 2020

T cell apoptosis by tryptophan catabolism

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12 December 2020

Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis

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12 December 2020

Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

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12 December 2020

Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine

1 reference

12 December 2020

Studying the immunosuppressive role of indoleamine 2,3-dioxygenase: tryptophan metabolites suppress rat allogeneic T-cell responses in vitro and in vivo

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12 December 2020

Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia

1 reference

12 December 2020

Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division

1 reference

12 December 2020

Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase.

1 reference

12 December 2020

Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis

1 reference

12 December 2020

Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections.

1 reference

12 December 2020

Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells

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12 December 2020

Decreased level of kynurenic acid in cerebrospinal fluid of relapsing-onset multiple sclerosis patients

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12 December 2020

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan

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12 December 2020

Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia

1 reference

12 December 2020

Selective expression of the large neutral amino acid transporter at the blood-brain barrier

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12 December 2020

Multiple sclerosis: a pivotal role for the T cell in lesion development

1 reference

12 December 2020

Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites

1 reference

12 December 2020

Oligodendrocyte killing by quinolinic acid in vitro

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12 December 2020

Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons

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12 December 2020

Characterization of rat brain kynurenine aminotransferases I and II.

1 reference

12 December 2020

Neurotoxin quinolinic acid is selectively elevated in spinal cords of rats with experimental allergic encephalomyelitis

1 reference

12 December 2020

HIV-1 and the brain: connections between HIV-1-associated dementia, neuropathology and neuroimmunology

1 reference

12 December 2020

Early entry and widespread cellular involvement of HIV-1 DNA in brains of HIV-1 positive asymptomatic individuals

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12 December 2020

Dendritic cell-mediated T cell polarization

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12 December 2020

Expression of indoleamine 2,3-dioxygenase, tryptophan degradation, and kynurenine formation during in vivo infection with Toxoplasma gondii: induction by endogenous gamma interferon and requirement of interferon regulatory factor 1.

1 reference

12 December 2020

Interferon-gamma-induced activation of indoleamine 2,3-dioxygenase in cord blood monocyte-derived macrophages inhibits the growth of group B streptococci

1 reference

12 December 2020

Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism

1 reference

12 December 2020

Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL.

1 reference

12 December 2020

10.1007/S00109-007-0229-7

Identifiers

DOI

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16 August 2017

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