(Q36888154)

16 August 2017

title

The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway (English)

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16 August 2017

S Okada

1

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16 August 2017

A W Kao

2

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16 August 2017

B P Ceresa

3

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16 August 2017

P Blaikie

4

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16 August 2017

B Margolis

5

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16 August 2017

J E Pessin

6

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16 August 2017

language of work or name

English

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publication date

1 October 1997

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Journal of Biological Chemistry

16 August 2017

published in

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16 August 2017

volume

272

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16 August 2017

issue

44

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16 August 2017

page(s)

28042-28049

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Growth factor signaling by receptor tyrosine kinases

16 August 2017

cites work

1 reference

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Oncogenes and signal transduction

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Growth factors and cancer

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SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

21 January 2018

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A phosphotyrosine interaction domain

21 January 2018

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Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

21 January 2018

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An alternative to SH2 domains for binding tyrosine-phosphorylated proteins

21 January 2018

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The PTB domain: a new protein module implicated in signal transduction

21 January 2018

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

1 reference

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Binding of Shc to the NPXY motif is mediated by its N-terminal domain

21 January 2018

1 reference

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The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor

21 January 2018

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PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine

21 January 2018

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Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking

21 January 2018

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A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

21 January 2018

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Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation

21 January 2018

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C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

21 January 2018

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

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Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

21 January 2018

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

21 January 2018

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Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries

21 January 2018

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

21 January 2018

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The Son of sevenless Gene Product: a Putative Activator of Ras

21 January 2018

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Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras

21 January 2018

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Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

21 January 2018

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

21 January 2018

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

21 January 2018

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A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

21 January 2018

1 reference

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Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

21 January 2018

1 reference

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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

21 January 2018

1 reference

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Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity

21 January 2018

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Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors

21 January 2018

1 reference

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Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase

21 January 2018

1 reference

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Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

21 January 2018

1 reference

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A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.44.28042

21 January 2018

Identifiers

DOI

10.1074/JBC.272.44.28042

1 reference

16 August 2017

1 reference