(Q36893545)

English

ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia

scientific article published on 26 July 2007

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

ATP-binding-cassette transporters in hematopoietic stem cells and their utility as therapeutical targets in acute and chronic myeloid leukemia (English)

1 reference

Europe PubMed Central

16 August 2017

chronic myeloid leukemia

0 references

1 reference

based on heuristic

inferred from title

author name string

Raaijmakers MH

1

1 reference

Europe PubMed Central

16 August 2017

publication date

26 July 2007

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

21

1 reference

Europe PubMed Central

16 August 2017

2094-2102

1 reference

Europe PubMed Central

16 August 2017

10

1 reference

Europe PubMed Central

16 August 2017

https://scigraph.springernature.com/pub.10.1038/sj.leu.2404859

0 references

The human ATP-binding cassette (ABC) transporter superfamily

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Mammalian ABC transporters in health and disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Modification of rhodamine staining allows identification of hematopoietic stem cells with preferential short-term or long-term bone marrow-repopulating ability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

ABC transporter activities of murine hematopoietic stem cells vary according to their developmental and activation status

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Liver and marrow of adult mdr-1a/1b(-/-) mice show normal generation, function, and multi-tissue trafficking of primitive hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Cloning and functional analysis of the rhesus macaque ABCG2 gene. Forced expression confers an SP phenotype among hematopoietic stem cell progeny in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Quantitative assessment of gene expression in highly purified hematopoietic cells using real-time reverse transcriptase polymerase chain reaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Mining our ABCs: pharmacogenomic approach for evaluating transporter function in cancer drug resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Evidence that a cell-type-specific efflux pump regulates cell differentiation in Dictyostelium.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Effects of retroviral-mediated MDR1 expression on hematopoietic stem cell self-renewal and differentiation in culture

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

The effect of multidrug-resistance 1 gene versus neo transduction on ex vivo and in vivo expansion of rhesus macaque hematopoietic repopulating cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Non-side-population hematopoietic stem cells in mouse bone marrow.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Expression and activity of multidrug resistance protein 1 in a murine thymoma cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Single-cell image analysis to assess ABC-transporter-mediated efflux in highly purified hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

P-glycoprotein in acute myeloid leukaemia: therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

The cyclosporin PSC 833 increases survival and delays engraftment of human multidrug-resistant leukemia cells in xenotransplanted NOD-SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Molecular structure of a novel cholesterol-responsive A subclass ABC transporter, ABCA9

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

The role of arachidonic acid in normal and malignant hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Selective expression of cholesterol metabolism genes in normal CD34+CD38- cells with a heterogeneous expression pattern in AML cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Tumour stem cells and drug resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Hoechst 33342 efflux identifies a subpopulation of cytogenetically normal CD34(+)CD38(-) progenitor cells from patients with acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Targeting the multidrug resistance-1 transporter in AML: molecular regulation and therapeutic strategies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Breast cancer resistance protein in drug resistance of primitive CD34+38- cells in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Role reversal for anticancer agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Cyclosporin A is a broad-spectrum multidrug resistance modulator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

ABCA3 as a possible cause of drug resistance in childhood acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Active transport of imatinib into and out of cells: implications for drug resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

RNAi-mediated knockdown of P-glycoprotein using a transposon-based vector system durably restores imatinib sensitivity in imatinib-resistant CML cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Loss of P-glycoprotein expression in hematopoietic stem cells does not improve responses to imatinib in a murine model of chronic myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

hOCT 1 and resistance to imatinib

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

MDR1 gene expression and treatment outcome in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

MDR1 gene-related clonal selection and P-glycoprotein function and expression in relapsed or refractory acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Reduced function of the multidrug resistance P-glycoprotein in CD34+ cells of patients with aplastic anaemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

21 January 2018

ABC Transporters: From Microorganisms to Man

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

7 January 2021

based on heuristic

inferred from DOI database lookup

A low but functionally significant MDR1 expression protects primitive haemopoietic progenitor cells from anthracycline toxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

7 January 2021

based on heuristic

inferred from DOI database lookup

Preferential expression of a high number of ATP binding cassette transporters in both normal and leukemic CD34+CD38- cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

7 January 2021

based on heuristic

inferred from DOI database lookup

Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

7 January 2021

based on heuristic

inferred from DOI database lookup

Hematopoietic cells from mice that are deficient in both Bcrp1/Abcg2 and Mdr1a/1b develop normally but are sensitized to mitoxantrone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

7 January 2021

based on heuristic

inferred from DOI database lookup

Dendritic cells require multidrug resistance protein 1 (ABCC1) transporter activity for differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

7 January 2021

based on heuristic

inferred from DOI database lookup

ABCB1 modulation does not circumvent drug extrusion from primitive leukemic progenitor cells and may preferentially target residual normal cells in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

7 January 2021

based on heuristic

inferred from DOI database lookup

Bryostatin-I: an antineoplastic treasure from the deep?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeted CML therapy: controlling drug resistance, seeking cure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

7 January 2021

based on heuristic

inferred from DOI database lookup

The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

7 January 2021

based on heuristic

inferred from DOI database lookup

Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404859

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.LEU.2404859

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q36893545&oldid=2088328807"