(Q36926385)

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The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice.

scientific article published on 17 August 2015

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scholarly article

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Europe PubMed Central

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22 February 2020

The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26283735%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

cystic fibrosis

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transmembrane protein

0 references

insulin resistance

1 reference

based on heuristic

inferred from title

Vincent Poitout

7

1 reference

Europe PubMed Central

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22 February 2020

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Ghislaine Fontés

1

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22 February 2020

Julien Ghislain

2

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22 February 2020

Isma Benterki

3

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22 February 2020

Bader Zarrouki

4

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22 February 2020

Dominique Trudel

5

1 reference

Europe PubMed Central

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22 February 2020

Yves Berthiaume

6

1 reference

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22 February 2020

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17 August 2015

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22 February 2020

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Europe PubMed Central

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22 February 2020

64

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22 February 2020

12

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22 February 2020

4112-4122

1 reference

Europe PubMed Central

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22 February 2020

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4876763/fullTextXML

based on heuristic

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Insulin secretion abnormalities in exocrine pancreatic sufficient cystic fibrosis patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

New animal models of cystic fibrosis: what are they teaching us?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

Clinical care guidelines for cystic fibrosis-related diabetes: a position statement of the American Diabetes Association and a clinical practice guideline of the Cystic Fibrosis Foundation, endorsed by the Pediatric Endocrine Society

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

Recent trends in cystic fibrosis-related diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

Oral glucose tolerance testing in children with cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

A susceptibility gene for type 2 diabetes confers substantial risk for diabetes complicating cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

Cystic fibrosis-related diabetes: current trends in prevalence, incidence, and mortality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

DeltaF508-CFTR causes constitutive NF-kappaB activation through an ER-overload response in cystic fibrosis lungs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

Insulin sensitivity in cystic fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

A mouse model for the cystic fibrosis delta F508 mutation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

29 September 2017

Insulin resistance is associated with decreased clinical status in cystic fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

27 June 2018

Roles of insulin resistance and beta-cell dysfunction in the pathogenesis of glucose intolerance in cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

27 June 2018

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

27 June 2018

Mechanisms of glucose intolerance in cystic fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Is cystic fibrosis-related diabetes an apoptotic consequence of ER stress in pancreatic cells?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Elevated gluconeogenesis and lack of suppression by insulin contribute to cystic fibrosis-related diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Expression and localization of cystic fibrosis transmembrane conductance regulator in the rat endocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Glucose homeostasis and genotype-phenotype interplay in cystic fibrosis patients with CFTR gene deltaF508 mutation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

A proinflammatory, antiapoptotic phenotype underlies the susceptibility to acute pancreatitis in cystic fibrosis transmembrane regulator (-/-) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Insulin-secretion abnormalities and clinical deterioration related to impaired glucose tolerance in cystic fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Fat absorption in cystic fibrosis mice is impeded by defective lipolysis and post-lipolytic events

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Understanding cystic-fibrosis-related diabetes: best thought of as insulin deficiency?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Acidic duodenal pH alters gene expression in the cystic fibrosis mouse pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Small intestinal glucose absorption in cystic fibrosis: a study in human and transgenic DeltaF508 cystic fibrosis mouse tissues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Natural history of glucose tolerance, beta-cell function and peripheral insulin sensitivity in cystic fibrosis patients with fasting euglycemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Mapping of genetic factors influencing the weight of cystic fibrosis knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Cystic fibrosis-related diabetes: the role of peripheral insulin resistance and beta-cell dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Hepatic insulin resistance and defects in substrate utilization in cystic fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

No changes of insulin sensitivity in cystic fibrosis patients with different degrees of glucose tolerance: an epidemiological and longitudinal study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Insulin sensitivity and metabolic clearance rate of insulin in cystic fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Cystic fibrosis-related diabetes is associated with HLA DQB1 alleles encoding Asp-57- molecules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4876763

4 September 2018

Cystic fibrosis associated islet changes may provide a basis for diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26283735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes mellitus in cystic fibrosis is characterized by islet amyloidosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26283735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin sensitivity and insulin clearance in cystic fibrosis patients with normal and diabetic glucose tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/26283735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased glucose excursion in cystic fibrosis and its association with a worse clinical status

1 reference

https://pubmed.ncbi.nlm.nih.gov/26283735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endocrine pancreas in cystic fibrosis: An immunohistochemical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/26283735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic islets in older patients with cystic fibrosis with and without diabetes mellitus: morphometric and immunocytologic studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/26283735

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB14-0810

1 reference

Europe PubMed Central

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22 February 2020

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Europe PubMed Central

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22 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26283735%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

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