(Q36943034)

English

Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall

scientific article published on 02 October 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Alessio Fasano

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

language of work or name

0 references

publication date

2 October 2008

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

The American Journal of Pathology

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

173

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

1243-1252

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

JAM-A regulates permeability and inflammation in the intestine in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Tight junction modulators: promising candidates for drug delivery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study

1 reference

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29 September 2017

Unravelling the pathogenesis of inflammatory bowel disease

1 reference

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29 September 2017

IL-1beta causes an increase in intestinal epithelial tight junction permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Inflammatory bowel disease: is it really just another break in the wall?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application

1 reference

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29 September 2017

Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

1 reference

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29 September 2017

IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases

1 reference

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29 September 2017

Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Degranulation of paneth cells via toll-like receptor 9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Toll-like receptor signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Microorganisms and autoimmunity: making the barren field fertile?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Junctional adhesion molecules (JAMs): more molecules with dual functions?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Enhanced permeability of molecular weight markers and poorly bioavailable compounds across Caco-2 cell monolayers using the absorption enhancer, zonula occludens toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Purification and preliminary characterization of the zonula occludens toxin receptor from human (CaCo2) and murine (IEC6) intestinal cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Zonula occludens toxin is a powerful mucosal adjuvant for intranasally delivered antigens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration

1 reference

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29 September 2017

Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Involvement of a heterotrimeric G protein alpha subunit in tight junction biogenesis

1 reference

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29 September 2017

Identification of isoforms of G proteins and PKC that colocalize with tight junctions

1 reference

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29 September 2017

Symplekin, a novel type of tight junction plaque protein

1 reference

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29 September 2017

A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells

1 reference

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29 September 2017

Occludin: a novel integral membrane protein localizing at tight junctions

1 reference

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29 September 2017

Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro

1 reference

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29 September 2017

Tight junctions and the molecular basis for regulation of paracellular permeability

1 reference

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29 September 2017

Histopathology of intestinal inflammation related to reactive arthritis

1 reference

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29 September 2017

Structure of the human class I histocompatibility antigen, HLA-A2

1 reference

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29 September 2017

Cingulin, a new peripheral component of tight junctions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

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Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes

1 reference

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29 September 2017

Overview of the mucosal immune system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Cloning of a gene (zot) encoding a new toxin produced by Vibrio cholerae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

29 September 2017

Human zonulin, a potential modulator of intestinal tight junctions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

27 June 2018

Molecular architecture of tight junctions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

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Partitioning of paracellular conductance along the ileal crypt-villus axis: a hypothesis based on structural analysis with detailed consideration of tight junction structure-function relationships

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27 June 2018

Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

4 September 2018

Toll-dependent control mechanisms of CD4 T cell activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

4 September 2018

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4 September 2018

Wheat gluten causes dendritic cell maturation and chemokine secretion.

1 reference

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4 September 2018

'Educated' dendritic cells act as messengers from memory to naive T helper cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

4 September 2018

The effect of delta G on the transport and oral absorption of macromolecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

4 September 2018

Effect of the biologically active fragment of zonula occludens toxin, delta G, on the intestinal paracellular transport and oral absorption of mannitol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

4 September 2018

Enhancing the permeation of marker compounds and enaminone anticonvulsants across Caco-2 monolayers by modulating tight junctions using zonula occludens toxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

4 September 2018

Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

4 September 2018

The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570116

4 September 2018

Epithelial Tight Junction Structure in the Jejunum of Children with Acute and Treated Celiac Sprue

1 reference

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4 December 2018

Altered intestinal permeability to mannitol in diabetes mellitus type I

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal intestinal permeability to sugars in diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered mannitol absorption in diabetic children

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zonula occludens toxin (Zot) interferes with the induction of nasal tolerance to gliadin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal permeability and diabetes mellitus type 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Celiac disease--how to handle a clinical chameleon

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal permeability in diabetic diarrhoea

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural abnormalities of jejunal epithelial cell membranes in celiac sprue

1 reference

https://pubmed.ncbi.nlm.nih.gov/18832585

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2353/AJPATH.2008.080192

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

0 references

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