(Q36944784)

English

Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase- and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion

scientific article published on 21 August 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase- and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

0 references

phosphorylation

1 reference

based on heuristic

inferred from title

author name string

Hui Chen

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Alice Seraphina Lin

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Yunhua Li

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Chad E N Reiter

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Maria R Ver

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Michael J Quon

6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Michael J Quon

7

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

language of work or name

0 references

publication date

21 August 2008

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

283

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

43

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

29228-29238

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Therapeutic targets in hypertension: is there a place for antagonists of the most potent vasoconstrictors?

1 reference

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29 September 2017

Mechanisms of ET-1-induced endothelial dysfunction

1 reference

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29 September 2017

Foxs and Ets in the transcriptional regulation of endothelial cell differentiation and angiogenesis

1 reference

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29 September 2017

Dietary supplements and nutraceuticals in the management of andrologic disorders

1 reference

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29 September 2017

Cardiovascular actions of insulin

1 reference

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29 September 2017

DHEA in elderly women and DHEA or testosterone in elderly men.

1 reference

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29 September 2017

Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells

1 reference

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29 September 2017

FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity.

1 reference

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29 September 2017

Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms.

1 reference

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29 September 2017

FOXO transcription factors at the interface between longevity and tumor suppression

1 reference

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29 September 2017

Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo

1 reference

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29 September 2017

Dehydroepiandrosterone restoration of growth hormone gene expression in aging female rats, in vivo and in vitro: evidence for actions via estrogen receptors

1 reference

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29 September 2017

Direct agonist/antagonist functions of dehydroepiandrosterone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors

1 reference

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29 September 2017

Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies

1 reference

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29 September 2017

Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Vezf1/DB1 is an endothelial cell-specific transcription factor that regulates expression of the endothelin-1 promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Dehydroepiandrosterone sulfate and longevity: new clues for an old friend

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

The effects of dehydroepiandrosterone on carcinogenesis, obesity, the immune system, and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

The epidemiology of DHEAS and cardiovascular disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Reduction of atherosclerosis by administration of dehydroepiandrosterone. A study in the hypercholesterolemic New Zealand white rabbit with aortic intimal injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Divergent correlations of circulating dehydroepiandrosterone sulfate and testosterone with insulin levels and insulin receptor binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Pattern of Plasma Dehydroepiandrosterone Sulfate Levels in Humans from Birth to Adulthood: Evidence for Testicular Production*

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

29 September 2017

Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

27 June 2018

Dehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT1 and GLUT4 translocation to the plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

27 June 2018

Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

27 June 2018

Interaction of endothelin-1 and nitric oxide in endothelial barrier failure in the cat hindlimb

1 reference

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27 June 2018

Relation of dehydroepiandrosterone and dehydroepiandrosterone sulfate with cardiovascular disease risk factors in women: longitudinal results from the Massachusetts Women's Health Study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

27 June 2018

Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

27 June 2018

Androgenic and estrogenic metabolites in serum of mice fed dehydroepiandrosterone: relationship to antihyperglycemic effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

27 June 2018

A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

27 June 2018

In vitro effect of dehydroepiandrosterone sulfate on steroid receptors, aromatase, cyclooxygenase-2 expression, and steroid hormone production in preovulatory human granulosa cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

Treatment of spontaneously hypertensive rats with rosiglitazone and/or enalapril restores balance between vasodilator and vasoconstrictor actions of insulin with simultaneous improvement in hypertension and insulin resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

The effect of dehydroepiandrosterone sulfate (DHEAS) on myotonia: intracellular studies

1 reference

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4 September 2018

Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

Dehydroepiandrosterone stimulates nitric oxide release in vascular endothelial cells: evidence for a cell surface receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

Effect of DHEAS on skeletal muscle over the life span: the InCHIANTI study

1 reference

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4 September 2018

Adiponectin stimulates production of nitric oxide in vascular endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

Effect of 1-year oral administration of dehydroepiandrosterone to 60- to 80-year-old individuals on muscle function and cross-sectional area: a double-blind placebo-controlled trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

The relationship of circulating dehydroepiandrosterone, testosterone, and estradiol to stages of the menopausal transition and ethnicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Galpha(i2,3).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

Negative regulation of the forkhead transcription factor FKHR by Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2570854

4 September 2018

Dehydroepiandrosterone suppresses the elevated hepatic glucose-6-phosphatase and fructose-1,6-bisphosphatase activities in C57BL/Ksj-db/db mice: comparison with troglitazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18718910

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluid Shear Stress and NO Decrease the Activity of the Hydroxy-Methylglutaryl Coenzyme A Reductase in Endothelial Cells via the AMP-Activated Protein Kinase and FoxO1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18718910

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of dehydroepiandrosterone on insulin sensitivity in Otsuka Long-Evans Tokushima-fatty rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18718910

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of endothelin-1 to disruption of blood-brain barrier permeability in dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18718910

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of DHEA replacement on bone mineral density and body composition in elderly women and men

1 reference

https://pubmed.ncbi.nlm.nih.gov/18718910

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause

1 reference

https://pubmed.ncbi.nlm.nih.gov/18718910

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of effect of dehydroepiandrosterone in obese men

1 reference

https://pubmed.ncbi.nlm.nih.gov/18718910

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Failure of dehydroepiandrosterone to influence energy and protein metabolism in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18718910

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased plasma levels of dehydroepiandrosterone sulphate (DHEA-S) in normolipidaemic and hyperlipoproteinaemic young men with coronary artery disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18718910

12 December 2020

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Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men

1 reference

https://pubmed.ncbi.nlm.nih.gov/18718910

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M802906200

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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