(Q36945537)

17 August 2017

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title

The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease (English)

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17 August 2017

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Kun Ping Lu

1

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PubMed ID

17878917

17 August 2017

Xiao Zhen Zhou

series ordinal

2

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17 August 2017

1 November 2007

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Nature Reviews Molecular Cell Biology

17 August 2017

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17 August 2017

8

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17 August 2017

904-916

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17 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrm2261

17 August 2017

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cites work

Prevalent overexpression of prolyl isomerase Pin1 in human cancers

1 reference

Cell division in the CNS: protective response or lethal event in post-mitotic neurons?

21 January 2018

1 reference

Utilizing the peptidyl-prolyl cis-trans isomerase pin1 as a probe of its phosphorylated target proteins. Examples of binding to nuclear proteins in a human kidney cell line and to tau in Alzheimer's diseased brain.

21 January 2018

1 reference

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

21 January 2018

1 reference

Alzheimer disease and cancer

21 January 2018

1 reference

Protein phosphorylation in signaling--50 years and counting

21 January 2018

1 reference

Oncogenic kinase signalling

31 March 2020

1 reference

Mitotic kinases as regulators of cell division and its checkpoints

31 March 2020

1 reference

Proline-directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease

31 March 2020

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Pinning down cell signaling, cancer and Alzheimer's disease

31 March 2020

1 reference

Phosphorylation-specific prolyl isomerization: is there an underlying theme?

31 March 2020

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A human peptidyl-prolyl isomerase essential for regulation of mitosis

31 March 2020

1 reference

Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

31 March 2020

1 reference

Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent

31 March 2020

1 reference

Regulation of peptide bond cis/trans isomerization by enzyme catalysis and its implication in physiological processes

31 March 2020

1 reference

Function of WW domains as phosphoserine- or phosphothreonine-binding modules

31 March 2020

1 reference

Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism.

31 March 2020

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A role for Pin1 in mammalian germ cell development and spermatogenesis

31 March 2020

1 reference

Pin1: a proline isomerase that makes you wheeze?

31 March 2020

1 reference

Protein twists and turns in Alzheimer disease

31 March 2020

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Pin1 in Alzheimer's disease

31 March 2020

1 reference

Pin-ning down immune responses to RNA viruses.

31 March 2020

1 reference

CELL SIGNALING: Mitochondrial Longevity Pathways

31 March 2020

1 reference

Peptidyl-prolyl cis/trans isomerases and transcription: is there a twist in the tail?

31 March 2020

1 reference

Hepatitis B virus x protein and pin1 in liver cancer: "les liaisons dangereuses".

31 March 2020

1 reference

PIN1, the cell cycle and cancer.

31 March 2020

1 reference

Native state proline isomerization: an intrinsic molecular switch

31 March 2020

1 reference

Prolyl isomerization as a molecular timer in phage infection

31 March 2020

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Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel.

31 March 2020

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Proline isomerization of histone H3 regulates lysine methylation and gene expression

31 March 2020

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Proline cis-trans isomerization controls autoinhibition of a signaling protein

31 March 2020

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Prolyl cis-trans Isomerization as a molecular timer in Crk signaling

31 March 2020

1 reference

Evidence that the substrate backbone conformation is critical to phosphorylation by p42 MAP kinase

31 March 2020

1 reference

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

31 March 2020

1 reference

Increased backbone flexibility in threonine45-phosphorylated hirudin upon pH change

31 March 2020

1 reference

All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae

31 March 2020

1 reference

PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans

31 March 2020

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Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest.

31 March 2020

1 reference

Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase

31 March 2020

1 reference

Crosstalk of prolyl isomerases, Pin1/Ess1, and cyclophilin A.

31 March 2020

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Functional conservation of phosphorylation-specific prolyl isomerases in plants

31 March 2020

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Identification and characterization of a novel and functional murine Pin1 isoform

31 March 2020

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The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

31 March 2020

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Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.

31 March 2020

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Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC

31 March 2020

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Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes

31 March 2020

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Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

31 March 2020

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Structural basis for phosphoserine-proline recognition by group IV WW domains

31 March 2020

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1H NMR study on the binding of Pin1 Trp-Trp domain with phosphothreonine peptides

31 March 2020

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Peptide binding induces large scale changes in inter-domain mobility in human Pin1.

31 March 2020

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Regulation of Pin1 peptidyl-prolylcis/transisomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau protein

31 March 2020

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The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

31 March 2020

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Substrate recognition reduces side-chain flexibility for conserved hydrophobic residues in human Pin1

31 March 2020

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Sequence-specific dynamics modulate recognition specificity in WW domains

31 March 2020

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Structure and dynamics of pin1 during catalysis by NMR.

31 March 2020

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Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR.

31 March 2020

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Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function

31 March 2020

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Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

31 March 2020

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Pin1 allows for differential Tau dephosphorylation in neuronal cells

31 March 2020

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Pin1 regulates the timing of mammalian primordial germ cell proliferation

31 March 2020

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PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells

31 March 2020

1 reference

BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression

31 March 2020

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Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells

31 March 2020

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Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis.

31 March 2020

1 reference

Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease

31 March 2020

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The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins

31 March 2020

1 reference

The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1

31 March 2020

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Requirement of the prolyl isomerase Pin1 for the replication checkpoint.

31 March 2020

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Pin1 acts catalytically to promote a conformational change in Cdc25.

31 March 2020

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Targets of the cyclin-dependent kinase Cdk1

31 March 2020

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Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase

31 March 2020

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Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF(betatrcp).

31 March 2020

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The prolyl isomerase Pin1 functions in mitotic chromosome condensation.

31 March 2020

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A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

31 March 2020

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Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms

31 March 2020

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Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesis

31 March 2020

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Centrosome aberrations: cause or consequence of cancer progression?

31 March 2020

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Centrosomes in cellular regulation

31 March 2020

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Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics

31 March 2020

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Targeting carcinogenesis: a role for the prolyl isomerase Pin1?

31 March 2020

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Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction

31 March 2020

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Regulation of Raf-1 by direct feedback phosphorylation.

31 March 2020

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Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis

31 March 2020

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Specific protection against breast cancers by cyclin D1 ablation

31 March 2020

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PIN1 overexpression and beta-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma

31 March 2020

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The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability

31 March 2020

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Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1

31 March 2020

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Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression

31 March 2020

1 reference

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

31 March 2020

1 reference

From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance

31 March 2020

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Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage

31 March 2020

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The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

31 March 2020

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The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

31 March 2020

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Pin1 links the activities of c-Abl and p300 in regulating p73 function.

31 March 2020

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Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc

31 March 2020

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

31 March 2020

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Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function

31 March 2020

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Opposite regulation of oligodendrocyte apoptosis by JNK3 and Pin1 after spinal cord injury

31 March 2020

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Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery

31 March 2020

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Neurodegenerative tauopathies

31 March 2020

1 reference

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

31 March 2020

1 reference

Pathways towards and away from Alzheimer's disease

31 March 2020

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

31 March 2020

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A century of Alzheimer's disease

31 March 2020

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The cell cycle in Alzheimer disease: a unique target for neuropharmacology

31 March 2020

1 reference

APP processing is regulated by cytoplasmic phosphorylation

31 March 2020

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Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies

31 March 2020

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Shortfalls in the peptidyl-prolyl cis-trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias.

31 March 2020

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The effect of age and Alzheimer's disease on pyramidal neuron density in the individual fields of the hippocampal formation

31 March 2020

1 reference

The human PIN1 peptidyl-prolyl cis/trans isomerase gene maps to human chromosome 19p13 and the closely related PIN1L gene to 1p31

31 March 2020

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Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2.

31 March 2020

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PIN1 promoter polymorphisms are associated with Alzheimer's disease.

31 March 2020

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Association study of the PIN1 gene with Alzheimer's disease.

31 March 2020

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Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer's disease

31 March 2020

1 reference

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

31 March 2020

1 reference

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

31 March 2020

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Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

31 March 2020

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

31 March 2020

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Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

31 March 2020

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Pin1 promotes production of Alzheimer's amyloid beta from beta-cleaved amyloid precursor protein

31 March 2020

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Genetically engineered mouse models of neurodegenerative diseases

31 March 2020

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A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease.

31 March 2020

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NF-kappaB in cancer: from innocent bystander to major culprit

31 March 2020

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Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.

31 March 2020

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AP-1 as a regulator of cell life and death

31 March 2020

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NF-kappaB: linking inflammation and immunity to cancer development and progression

31 March 2020

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The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils.

31 March 2020

1 reference

Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.

31 March 2020

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Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1.

31 March 2020

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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

31 March 2020

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The mechanism of action of cyclosporin A and FK506

31 March 2020

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High Pin1 expression is associated with tumor progression in colorectal cancer

31 March 2020

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Overexpression of Pin1 in non-small cell lung cancer (NSCLC) and its correlation with lymph node metastases.

31 March 2020

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Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis

31 March 2020

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Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone.

31 March 2020

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Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation

31 March 2020

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Conformationally locked isostere of phosphoSer-cis-Pro inhibits Pin1 23-fold better than phosphoSer-trans-Pro isostere

31 March 2020

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Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries

31 March 2020

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Structural Basis for High-Affinity Peptide Inhibition of Human Pin1

31 March 2020

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Cerebrospinal fluid tau, A beta, and phosphorylated tau protein for the diagnosis of Alzheimer's disease.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM2261

1 reference

17 August 2017

1 reference

PubMed ID

17878917