(Q36948514)

17 August 2017

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title

Altered innate immunity in chronic hepatitis C infection: cause or effect? (English)

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17 August 2017

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Gyongyi Szabo

1

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17 August 2017

Serena Chang

series ordinal

2

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17 August 2017

Angela Dolganiuc

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

1 October 2007

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17 August 2017

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17 August 2017

volume

46

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17 August 2017

issue

4

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17 August 2017

page(s)

1279-1290

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Subcellular localization of Toll-like receptor 3 in human dendritic cells

17 August 2017

cites work

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Microglia recognize double-stranded RNA via TLR3.

21 January 2018

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Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

21 January 2018

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Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation

21 January 2018

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Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.

21 January 2018

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Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

21 January 2018

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Antiviral signaling through pattern recognition receptors

21 January 2018

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Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation.

21 January 2018

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Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection

21 January 2018

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Flow cytometry assay of myeloid dendritic cells (mDCs) in peripheral blood during acute hepatitis C: possible pathogenetic mechanisms

21 January 2018

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Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection.

21 January 2018

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Negative regulation of NK cell activities by inhibitory receptor CD94/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection

21 January 2018

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DNA-based immunization breaks tolerance in a hepatitis C virus transgenic mouse model

21 January 2018

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FOXP3+CD4+CD25+ Adaptive Regulatory T Cells Express Cyclooxygenase-2 and Suppress Effector T Cells by a Prostaglandin E2-Dependent Mechanism

21 January 2018

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Broad Specificity of Virus-Specific CD4+ T-Helper-Cell Responses in Resolved Hepatitis C Virus Infection

21 January 2018

1 reference

7 January 2021

Determinants of viral clearance and persistence during acute hepatitis C virus infection

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7 January 2021

Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers

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7 January 2021

Comprehensive Analysis of CD8+-T-Cell Responses against Hepatitis C Virus Reveals Multiple Unpredicted Specificities

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7 January 2021

A primer on the molecular virology of hepatitis C.

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7 January 2021

Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses

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7 January 2021

Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and -independent mechanisms

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7 January 2021

Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection

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7 January 2021

Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease

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7 January 2021

Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling

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7 January 2021

Hepatitis C virus core protein down-regulates transcription of interferon-induced antiviral genes.

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7 January 2021

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

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7 January 2021

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

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7 January 2021

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

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7 January 2021

Antibodies against human Toll-like receptors (TLRs): TLR distribution and localization in human dendritic cells

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7 January 2021

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

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7 January 2021

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

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7 January 2021

Differential expression of toll-like receptor mRNA in treatment non-responders and sustained virologic responders at baseline in patients with chronic hepatitis C.

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7 January 2021

Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

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7 January 2021

Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses

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7 January 2021

Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses

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7 January 2021

Innate sensing of self and non-self RNAs by Toll-like receptors

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7 January 2021

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

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7 January 2021

Recognition of single-stranded RNA viruses by Toll-like receptor 7

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7 January 2021

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

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7 January 2021

Activation of anti-hepatitis C virus responses via Toll-like receptor 7.

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7 January 2021

Roles of toll-like receptors in natural interferon-producing cells as sensors in immune surveillance

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7 January 2021

Expression and function of Toll-like receptors in T lymphocytes

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7 January 2021

Drosophila Toll and IL-1 receptor

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7 January 2021

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

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7 January 2021

Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells

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7 January 2021

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

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7 January 2021

Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7

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7 January 2021

Impact of ribavirin dose reductions in hepatitis C virus genotype 1 patients completing peginterferon alfa-2a/ribavirin treatment

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7 January 2021

Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection

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7 January 2021

CARD games between virus and host get a new player

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7 January 2021

Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I

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7 January 2021

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

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7 January 2021

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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7 January 2021

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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7 January 2021

VISA is an adapter protein required for virus-triggered IFN-beta signaling

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7 January 2021

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

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7 January 2021

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

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7 January 2021

Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage

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7 January 2021

Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease

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7 January 2021

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

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7 January 2021

Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6

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7 January 2021

Cytoskeleton rearrangement induced by tetraspanin engagement modulates the activation of T and NK cells

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7 January 2021

Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein

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7 January 2021

Binding of the Hepatitis C Virus Envelope Protein E2 to CD81 Inhibits Natural Killer Cell Functions

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7 January 2021

Up-regulation of ERK and p38 MAPK signaling pathways by hepatitis C virus E2 envelope protein in human T lymphoma cell line

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7 January 2021

Binding of HCV E2 to CD81 induces RANTES secretion and internalization of CC chemokine receptor 5.

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7 January 2021

Cell activation by synthetic lipopeptides of the hepatitis C virus (HCV)--core protein is mediated by toll like receptors (TLRs) 2 and 4.

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7 January 2021

Hepatitis C virus expression suppresses interferon signaling by degrading STAT1

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7 January 2021

Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression

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7 January 2021

Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation

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7 January 2021

Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes.

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7 January 2021

Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis

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7 January 2021

Nonstructural Protein Precursor NS4A/B from Hepatitis C Virus Alters Function and Ultrastructure of Host Secretory Apparatus

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7 January 2021

Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation

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7 January 2021

Toll-like receptors; their physiological role and signal transduction system

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7 January 2021

Reduced expression and functional impairment of Toll-like receptor 2 on dendritic cells in chronic hepatitis C virus infection

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7 January 2021

Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions

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7 January 2021

Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes

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7 January 2021

Interferons, immunity and cancer immunoediting

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7 January 2021

Immunology of hepatitis B virus and hepatitis C virus infection

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7 January 2021

Adaptive immune responses in acute and chronic hepatitis C virus infection

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7 January 2021

Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics

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7 January 2021

SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29.

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7 January 2021

Lambda interferon inhibits hepatitis B and C virus replication

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7 January 2021

Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis

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7 January 2021

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

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7 January 2021

Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein

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7 January 2021

Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action

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7 January 2021

Reduced numbers and impaired ability of myeloid and plasmacytoid dendritic cells to polarize T helper cells in chronic hepatitis C virus infection

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7 January 2021

Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease.

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7 January 2021

Infection and dysfunction of circulating blood dendritic cells and their subsets in chronic hepatitis C virus infection

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7 January 2021

Presence of functional dendritic cells in patients chronically infected with hepatitis C virus

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7 January 2021

Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virus

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7 January 2021

Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection

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7 January 2021

Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection

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7 January 2021

Evidence of viral replication in circulating dendritic cells during hepatitis C virus infection

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7 January 2021

Comparable functions of plasmacytoid and monocyte-derived dendritic cells in chronic hepatitis C patients and healthy donors

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7 January 2021

Quantification and functional analysis of plasmacytoid dendritic cells in patients with chronic hepatitis C virus infection

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7 January 2021

Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C.

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7 January 2021

Enhanced expression of interferon-regulated genes in the liver of patients with chronic hepatitis C virus infection: detection by suppression-subtractive hybridization

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7 January 2021

Interferon type I gene expression in chronic hepatitis C.

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7 January 2021

Decreased interferon-alpha production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C

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7 January 2021

Impaired function of dendritic cells circulating in patients infected with hepatitis C virus who have persistently normal alanine aminotransferase levels

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7 January 2021

Toll-like receptor expression in chronic hepatitis C: Correlation with pro-inflammatory cytokine levels and liver injury

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7 January 2021

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7 January 2021

Expression of CD163 in the liver of patients with viral hepatitis

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7 January 2021

Expression of co-stimulatory molecules by Kupffer cells in chronic hepatitis of hepatitis C virus etiology

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7 January 2021

Biological and clinical significance of endotoxemia in the course of hepatitis C virus infection

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7 January 2021

A study of susceptibility of primary human Kupffer cells to hepatitis C virus

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7 January 2021

Innate and adaptive lymphoid cells in the human liver

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7 January 2021

Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis.

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7 January 2021

Decreased NK cell frequency in chronic hepatitis C does not affect ex vivo cytolytic killing

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7 January 2021

Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C.

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7 January 2021

Natural killer cells inhibit hepatitis C virus expression

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7 January 2021

HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection

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7 January 2021

Protective effect of the HLA-Bw4I80 epitope and the killer cell immunoglobulin-like receptor 3DS1 gene against the development of hepatocellular carcinoma in patients with hepatitis C virus infection

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7 January 2021

Natural killer cells: primary target for hepatitis C virus immune evasion strategies?

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7 January 2021

Induction of oral immune regulation towards liver-extracted proteins for treatment of chronic HBV and HCV hepatitis: results of a phase I clinical trial

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7 January 2021

Enhanced ability of peripheral invariant natural killer T cells to produce IL-13 in chronic hepatitis C virus infection

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7 January 2021

Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection

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7 January 2021

Selective reduction of natural killer cells and T cells expressing inhibitory receptors for MHC class I in the livers of patients with hepatic malignancy.

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7 January 2021

CpG immuno-stimulatory motifs enhance humoral immune responses against hepatitis C virus core protein after DNA-based immunization.

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7 January 2021

Hepatitis C virus-like particles combined with novel adjuvant systems enhance virus-specific immune responses

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7 January 2021

Enhanced hepatitis C virus NS3 specific Th1 immune responses induced by co-delivery of protein antigen and CpG with cationic liposomes

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7 January 2021

Priming with CpG-enriched plasmid and boosting with protein formulated with CpG oligodeoxynucleotides and Quil A induces strong cellular and humoral immune responses to hepatitis C virus NS3.

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7 January 2021

TLR7/8 agonists impair monocyte-derived dendritic cell differentiation and maturation

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7 January 2021

Membrane association of hepatitis C virus nonstructural proteins and identification of the membrane alteration that harbors the viral replication complex

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7 January 2021

Recent developments in the discovery of hepatitis C virus serine protease inhibitors--towards a new class of antiviral agents?

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7 January 2021

Selective inhibitors of hepatitis C virus replication

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7 January 2021

Evasion of intracellular host defence by hepatitis C virus

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7 January 2021

Interferon-alpha combined with ketoprofen as treatment of naïve patients with chronic hepatitis C: a randomized controlled trial.

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7 January 2021

Chronic ethanol consumption impairs cellular immune responses against HCV NS5 protein due to dendritic cell dysfunction

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7 January 2021

In vivo clearance of hepatitis C virus nonstructural 3/4A-expressing hepatocytes by DNA vaccine-primed cytotoxic T lymphocytes

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7 January 2021

DNA-based immunotherapy: potential for treatment of chronic viral hepatitis?

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7 January 2021

Identifiers

DOI

10.1002/HEP.21938

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17 August 2017

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