(Q36948888)

English

Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism

scientific article published on August 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

0 references

0 references

1 reference

based on heuristic

inferred from title

author name string

Karel Tyml

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Fuyan Li

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

John X Wilson

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

language of work or name

0 references

publication date

1 August 2008

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Critical Care Medicine

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

36

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

2355-2362

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

An in-vivo analysis of capillary stasis and endothelial apoptosis in a model of hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Getting to the site of inflammation: the leukocyte adhesion cascade updated

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Consensus meeting on "Relevance of parenteral vitamin C in acute endothelial dependent pathophysiological conditions (EDPC)".

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Endothelial nitric oxide synthase in vascular disease: from marvel to menace

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Effects of epinephrine, norepinephrine, and phenylephrine on microcirculatory blood flow in the gastrointestinal tract in sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Endothelial nitric oxide synthase (eNOS) in platelets: how is it regulated and what is it doing there?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Delayed ascorbate bolus protects against maldistribution of microvascular blood flow in septic rat skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: interpreting capillary oxygen transport data using a mathematical model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Inducible Nitric Oxide Synthase - Time for Reappraisal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Early goal-directed therapy in the treatment of severe sepsis and septic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

How does ascorbic acid prevent endothelial dysfunction?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Enzymatic function of nitric oxide synthases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Temporal sequence of pulmonary and systemic inflammatory responses to graded polymicrobial peritonitis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Effects of isoproterenol on myocardial structure and function in septic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Microvascular perfusion is impaired in a rat model of normotensive sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Gram-negative sepsis. Background, clinical features, and intervention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

29 September 2017

Nitric oxide produced via neuronal NOS may impair vasodilatation in septic rat skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

27 June 2018

Nitric oxide release in rat skeletal muscle capillary

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

27 June 2018

Arteriolar endothelium-dependent vasodilation occurs during endotoxin shock.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

27 June 2018

Deletion of neuronal NOS prevents impaired vasodilation in septic mouse skeletal muscle.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Ascorbate inhibits NADPH oxidase subunit p47phox expression in microvascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Platelet recruitment in the murine hepatic microvasculature during experimental sepsis: role of neutrophils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Nitric oxide-dependent reduction in soluble guanylate cyclase functionality accounts for early lipopolysaccharide-induced changes in vascular reactivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle is mediated by nNOS-derived NO.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Superoxide scavenging effects of N-acetylcysteine and vitamin C in subjects with essential hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Ascorbate protects against impaired arteriolar constriction in sepsis by inhibiting inducible nitric oxide synthase expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

The beneficial effects of antioxidant supplementation in enteral feeding in critically ill patients: a prospective, randomized, double-blind, placebo-controlled trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Conducted vasoconstriction is reduced in a mouse model of sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Ascorbate inhibits iNOS expression and preserves vasoconstrictor responsiveness in skeletal muscle of septic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Heme oxygenase and nitric oxide synthase mediate cooling-associated protection against TNF-alpha-induced microcirculatory dysfunction and apoptotic cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Superoxide mediates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

A 4-amino analogue of tetrahydrobiopterin attenuates endotoxin-induced hemodynamic alterations and organ injury in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Association between mitochondrial dysfunction and severity and outcome of septic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Vitamin C matters: increased oxidative stress in cultured human aortic endothelial cells without supplemental ascorbic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Augmented oxidative stress of platelets in chronic smokers. Mechanisms of impaired platelet-derived nitric oxide bioactivity and augmented platelet aggregability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2572871

4 September 2018

Ascorbic acid synthesis due to l-gulono-1,4-lactone oxidase expression enhances NO production in endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18596627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abrupt reoxygenation of microvascular endothelial cells after hypoxia activates ERK1/2 and JNK1, leading to NADPH oxidase-dependent oxidant production

1 reference

https://pubmed.ncbi.nlm.nih.gov/18596627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitroglycerin in septic shock after intravascular volume resuscitation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18596627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide induces leukocyte rolling: modulation by endogenous antioxidant mechanisms including NO

1 reference

https://pubmed.ncbi.nlm.nih.gov/18596627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inducible nitric oxide synthase and vascular reactivity in rat thoracic aorta: effect of aminoguanidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18596627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ascorbate uptake by microvascular endothelial cells of rat skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18596627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leukocyte activation and flow behavior in rat skeletal muscle in sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18596627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endotoxin-induced skeletal muscle contractile dysfunction: contribution of nitric oxide synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18596627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ascorbate Prevents the Interaction of Superoxide and Nitric Oxide Only at Very High Physiological Concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/18596627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18596627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endotoxin promotes adhesion of human erythrocytes to human vascular endothelial cells under conditions of flow

1 reference

https://pubmed.ncbi.nlm.nih.gov/18596627

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1097/CCM.0B013E31818024F6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

0 references

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