(Q36953788)

English

Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity

scientific article published on 07 May 2008

In more languages

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Cheng Fang

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Jun Gu

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Fang Xie

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Melissa Behr

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Weizhu Yang

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

E Dale Abel

6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Xinxin Ding

7

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

publication date

7 May 2008

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Drug Metabolism and Disposition

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

36

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

1722-1728

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Detection of human CYP2C8, CYP2C9, and CYP2J2 in cardiovascular tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Molecular pharmacology of the interaction of anthracyclines with iron

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8, 2C9, and 2J2 in human tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Human NADPH-cytochrome p450 reductase overexpression does not enhance the aerobic cytotoxicity of doxorubicin in human breast cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Cytochrome p450 and vascular homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Human carbonyl reductase overexpression in the heart advances the development of doxorubicin-induced cardiotoxicity in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

29 September 2017

Further characterization of the expression in liver and catalytic activity of CYP2B6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

27 June 2018

A continuous fluorometric assay for cytochrome P-450-dependent mixed function oxidases using 3-cyano-7-ethoxycoumarin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

27 June 2018

Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

4 September 2018

Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

4 September 2018

Cancer chemotherapy and drug metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

4 September 2018

Heterozygous knockout of neuregulin-1 gene in mice exacerbates doxorubicin-induced heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

4 September 2018

Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

4 September 2018

Targeted Disruption of the Olfactory Mucosa-SpecificCyp2g1Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, and Tissue-Selective Effects onCyp2a5Expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

4 September 2018

Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

4 September 2018

Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

4 September 2018

Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

4 September 2018

Induction of cardiac cytochrome p450 in cocaine-treated mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

4 September 2018

Metabolic activation of the food mutagen Trp-P-1 in endothelial cells of heart and kidney in cytochrome P450-induced mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2575052

4 September 2018

Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticancer derivative of butyric acid (Pivalyloxymethyl butyrate) specifically potentiates the cytotoxicity of doxorubicin and daunorubicin through the suppression of microsomal glycosidic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adriamycin-induced early changes in myocardial antioxidant enzymes and their modulation by probucol

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anthracycline antibiotic-stimulated superoxide, hydrogen peroxide, and hydroxyl radical production by NADH dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doxorubicin-induced cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of tone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiotoxicity of antitumor drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463197

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/DMD.108.021881

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

0 references

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