(Q36973716)

English

Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis

scientific article published on 17 September 2008

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18799464%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18799464%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

cystic fibrosis

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3

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14 January 2020

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18799464%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Catherine M Greene

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18799464%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Clifford C Taggart

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18799464%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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Nicolas Guyot

1

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14 January 2020

Marcus W Butler

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18799464%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Rodney L Levine

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18799464%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Shane J O'Neill

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18799464%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Noel G McElvaney

9

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14 January 2020

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17 September 2008

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Europe PubMed Central

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14 January 2020

Journal of Biological Chemistry

1 reference

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14 January 2020

283

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14 January 2020

47

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18799464%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

32377-32385

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18799464%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Phosphorylation of actin Tyr-53 inhibits filament nucleation and elongation and destabilizes filaments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Lipopolysaccharide-binding molecules: transporters, blockers and sensors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Adenoviral gene delivery of elafin and secretory leukocyte protease inhibitor attenuates NF-kappa B-dependent inflammatory responses of human endothelial cells and macrophages to atherogenic stimuli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Airways in cystic fibrosis are acidified: detection by exhaled breath condensate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Cytokine-mediated induction of the human elafin gene in pulmonary epithelial cells is regulated by nuclear factor-kappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Human alveolar macrophages express elafin and secretory leukocyte protease inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Human neutrophil elastase regulates the expression and secretion of elafin (elastase-specific inhibitor) in type II alveolar epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Solution structure of R-elafin, a specific inhibitor of elastase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Transferrin and lactoferrin undergo proteolytic cleavage in the Pseudomonas aeruginosa-infected lungs of patients with cystic fibrosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

On the size of the active site in proteases. I. Papain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

Action of human lysosomal elastase on the oxidized B chain of insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

29 September 2017

The use of induced sputum to investigate airway inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

27 June 2018

Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

27 June 2018

Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

4 September 2018

Elafin and its precursor trappin-2 still inhibit neutrophil serine proteinases when they are covalently bound to extracellular matrix proteins by tissue transglutaminase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

4 September 2018

Proteolytic susceptibility of the serine protease inhibitor trappin-2 (pre-elafin): evidence for tryptase-mediated generation of elafin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

4 September 2018

The antimicrobial antiproteinase elafin binds to lipopolysaccharide and modulates macrophage responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

4 September 2018

NF-kappaB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

4 September 2018

Kinetics of the inhibition of neutrophil proteinases by recombinant elafin and pre-elafin (trappin-2) expressed in Pichia pastoris

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

4 September 2018

Supernatants of Pseudomonas aeruginosa induce the Pseudomonas-specific antibiotic elafin in human keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

4 September 2018

Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

4 September 2018

Up-regulation of elafin/SKALP gene expression in psoriatic epidermis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

4 September 2018

Inactivation of human bronchial mucosal proteinase inhibitor by Pseudomonas aeruginosa elastase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2583315

4 September 2018

Regulation of Adenovirus-Mediated Elafin Transgene Expression by Bacterial Lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803707200

21 January 2018

Anti-Inflammatory Effect of Pre-Elafin in Lipopolysaccharide-Induced Acute Lung Inflammation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803707200

21 January 2018

Antiprotease activity in urine of patients with inflammatory skin disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/18799464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of elafin in actinic elastosis of sun-damaged skin: elafin binds to elastin and prevents elastolytic degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18799464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secretory leukocyte proteinase inhibitor is a major leukocyte elastase inhibitor in human neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/18799464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elafin (elastase-specific inhibitor) has anti-microbial activity against gram-positive and gram-negative respiratory pathogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/18799464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-alpha and interleukin-8

1 reference

https://pubmed.ncbi.nlm.nih.gov/18799464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolysis of subendothelial adhesive glycoproteins (fibronectin, thrombospondin, and von Willebrand factor) by plasmin, leukocyte cathepsin G, and elastase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18799464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-alpha and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAP kinase-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18799464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transglutaminase-sensitive glutamine residues of human plasma fibronectin revealed by studying its proteolytic fragments

1 reference

https://pubmed.ncbi.nlm.nih.gov/18799464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and structure-activity relationships of elafin, an elastase-specific inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18799464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of the inhibition of human leukocyte elastase by elafin, a 6-kilodalton elastase-specific inhibitor from human skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18799464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elastase inhibitor elafin is a new type of proteinase inhibitor which has a transglutaminase-mediated anchoring sequence termed "cementoin"

1 reference

https://pubmed.ncbi.nlm.nih.gov/18799464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SKALP/elafin is an inducible proteinase inhibitor in human epidermal keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18799464

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M803707200

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18799464%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

release_yka4mroftzhmzh7hp44owpnsyi

1 reference

https://api.fatcat.wiki/v0/release/yka4mroftzhmzh7hp44owpnsyi

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18799464%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18799464%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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