(Q36973896)

17 August 2017

A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair (English)

1 reference

17 August 2017

1 reference

Monica Florio

1

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17 August 2017

Kannan Gunasekaran

2

1 reference

17 August 2017

Marina Stolina

3

1 reference

17 August 2017

Xiaodong Li

4

1 reference

17 August 2017

Ling Liu

5

1 reference

17 August 2017

Barbara Tipton

6

1 reference

17 August 2017

Hossein Salimi-Moosavi

7

1 reference

17 August 2017

Franklin J Asuncion

8

1 reference

17 August 2017

Chaoyang Li

9

1 reference

17 August 2017

Banghua Sun

10

1 reference

17 August 2017

Hong Lin Tan

11

1 reference

17 August 2017

Li Zhang

12

1 reference

17 August 2017

Chun-Ya Han

13

1 reference

17 August 2017

Ryan Case

14

1 reference

17 August 2017

Amy N Duguay

15

1 reference

17 August 2017

Mario Grisanti

16

1 reference

17 August 2017

Jennitte Stevens

17

1 reference

17 August 2017

James K Pretorius

18

1 reference

17 August 2017

Efrain Pacheco

19

1 reference

17 August 2017

Heidi Jones

20

1 reference

17 August 2017

Qing Chen

21

1 reference

17 August 2017

Brian D Soriano

22

1 reference

17 August 2017

Jie Wen

23

1 reference

17 August 2017

Brenda Heron

24

1 reference

17 August 2017

Frederick W Jacobsen

25

1 reference

17 August 2017

Emil Brisan

26

1 reference

17 August 2017

William G Richards

27

1 reference

17 August 2017

Hua Zhu Ke

28

1 reference

17 August 2017

Michael S Ominsky

29

1 reference

17 August 2017

language of work or name

English

0 references

publication date

27 May 2016

1 reference

17 August 2017

Nature Communications

1 reference

17 August 2017

7

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17 August 2017

11505

1 reference

Creative Commons Attribution 4.0 International

17 August 2017

start time

27 May 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms11505

0 references

cites work

A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

WNT signaling in bone homeostasis and disease: from human mutations to treatments

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

The interpretation of protein structures: Estimation of static accessibility

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

The effect of teriparatide on serum Dickkopf-1 levels in postmenopausal women with established osteoporosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Uncovering methods for the prevention of protein aggregation and improvement of product quality in a transient expression system.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Tissue-level mechanisms responsible for the increase in bone formation and bone volume by sclerostin antibody

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Romosozumab in postmenopausal women with low bone mineral density.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Serum Dickkopf 1 levels in sclerostin deficiency.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Buy buy bispecific antibodies.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4894982

Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

4 September 2018

1 reference

12 December 2020

A Phase IB multicentre dose-determination study of BHQ880 in combination with anti-myeloma therapy and zoledronic acid in patients with relapsed or refractory multiple myeloma and prior skeletal-related events

1 reference

12 December 2020

Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats

1 reference

12 December 2020

Role of fracture hematoma and periosteum during fracture healing in rats: interaction of fracture hematoma and the periosteum in the initial step of the healing process

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS11505

1 reference

17 August 2017

0 references

1 reference

17 August 2017

1 reference