(Q36975163)

English

Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β.

scientific article published on 15 April 2013

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scholarly article

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28 February 2020

Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β (English)

1 reference

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28 February 2020

Harini Sreenivasappa

7

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28 February 2020

Grant M Fischer

8

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28 February 2020

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28 February 2020

Warren E. Zimmer

17

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28 February 2020

author name string

Christina L Papke

1

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28 February 2020

Jiumei Cao

2

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28 February 2020

Callie S Kwartler

3

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28 February 2020

Carlos Villamizar

4

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28 February 2020

Katerina L Byanova

5

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28 February 2020

Soon-Mi Lim

6

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28 February 2020

John Pham

9

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28 February 2020

Meredith Rees

10

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28 February 2020

Miranda Wang

11

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28 February 2020

Christine Chaponnier

12

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28 February 2020

Giulio Gabbiani

13

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28 February 2020

Aarif Y Khakoo

14

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28 February 2020

Joya Chandra

15

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28 February 2020

Dianna M Milewicz

18

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28 February 2020

publication date

15 April 2013

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28 February 2020

Human Molecular Genetics

1 reference

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28 February 2020

22

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28 February 2020

3123-3137

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28 February 2020

15

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28 February 2020

describes a project that uses

1 reference

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3699068/fullTextXML

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Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Imatinib mesylate for the treatment of pulmonary arterial hypertension

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Imatinib mesylate at therapeutic doses has no impact on folliculogenesis or spermatogenesis in a leukaemic mouse model

1 reference

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Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells

1 reference

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29 September 2017

Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity.

1 reference

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Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice

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1 reference

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29 September 2017

Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Atomic force microscopy (AFM).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Kinetics of repression by modified p53 on the PDGF beta-receptor promoter

1 reference

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29 September 2017

Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform dependent and stimulus dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

A common allele on chromosome 9 associated with coronary heart disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Cellular characterization of a novel focal adhesion kinase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Developmental basis of vascular smooth muscle diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Myocardin-related transcription factors: critical coactivators regulating cardiovascular development and adaptation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

p27Kip1 modulates cell migration through the regulation of RhoA activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Focal adhesion kinase: the first ten years

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

Mutant actins demonstrate a role for unpolymerized actin in control of transcription by serum response factor

1 reference

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29 September 2017

Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-delta and c-Src

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

29 September 2017

The NH2-terminal peptide of alpha-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo

1 reference

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Assembly and mechanosensory function of focal contacts

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Impaired vascular contractility and blood pressure homeostasis in the smooth muscle alpha-actin null mouse

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Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis.

1 reference

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Focal adhesions, contractility, and signaling

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Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation

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A function for filamentous alpha-smooth muscle actin: retardation of motility in fibroblasts

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Regulation of differentiation of vascular smooth muscle cells

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29 September 2017

Cell proliferation in human coronary arteries

1 reference

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29 September 2017

MAL and ternary complex factor use different mechanisms to contact a common surface on the serum response factor DNA-binding domain.

1 reference

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27 June 2018

Histamine effects on endothelial cell fibronectin interaction studied by atomic force microscopy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

27 June 2018

Proliferation and differentiation of smooth muscle cell precursors occurs simultaneously during the development of the vessel wall.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

27 June 2018

Differences in signal transduction between platelet-derived growth factor (PDGF) alpha and beta receptors in vascular smooth muscle cells. PDGF-BB is a potent mitogen, but PDGF-AA promotes only protein synthesis without activation of DNA synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

27 June 2018

PAR-2 inhibition reverses experimental pulmonary hypertension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

4 September 2018

De novo ACTA2 mutation causes a novel syndrome of multisystemic smooth muscle dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

4 September 2018

Imatinib mesilate inhibits neointimal hyperplasia via growth inhibition of vascular smooth muscle cells in a rat model of balloon injury

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4 September 2018

Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

4 September 2018

NF1 regulates a Ras-dependent vascular smooth muscle proliferative injury response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

4 September 2018

Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

4 September 2018

Imatinib for the treatment of pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

4 September 2018

Important role for Rac1 in regulating reactive oxygen species generation and pulmonary arterial smooth muscle cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

4 September 2018

Mechanosensitive p27Kip1 regulation and cell cycle entry in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

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Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

4 September 2018

Establishment of a murine model for therapy-treated chronic myelogenous leukemia using the tyrosine kinase inhibitor STI571.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

4 September 2018

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

4 September 2018

Cellular adhesion regulates p53 protein levels in primary human keratinocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

4 September 2018

A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3699068

20 October 2018

Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow

1 reference

https://pubmed.ncbi.nlm.nih.gov/23591991

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/23591991

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23591991

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smooth muscle alpha-actin deficiency in myofibroblasts leads to enhanced renal tissue fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23591991

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of flat punch indentation to determine the viscoelastic properties in the time and frequency domains of a soft layer bonded to a rigid substrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/23591991

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular matrix effect on RhoA signaling modulation in vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23591991

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imatinib for chronic myeloid leukemia: the impact of its effectiveness and long-term side effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/23591991

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Airways in smooth muscle α-actin null mice experience a compensatory mechanism that modulates their contractile response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23591991

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/HMG/DDT167

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23591991%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

Europe PubMed Central

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28 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23591991%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

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