(Q36975742)

17 August 2017

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title

Hydrogen sulphide and its therapeutic potential (English)

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17 August 2017

Csaba Szabó

1

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17 August 2017

1 November 2007

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Nature Reviews Drug Discovery

17 August 2017

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17 August 2017

6

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17 August 2017

917-935

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17 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrd2425

17 August 2017

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cites work

Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?

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The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver

31 March 2020

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Endogenous production of hydrogen sulfide in mammals

31 March 2020

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Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissues

31 March 2020

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Dynamics of carbon monoxide binding to cystathionine beta-synthase

31 March 2020

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A novel enhancing mechanism for hydrogen sulfide-producing activity of cystathionine beta-synthase

31 March 2020

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Cystathionine beta-synthase: structure, function, regulation, and location of homocystinuria-causing mutations

31 March 2020

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Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression

31 March 2020

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Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues: a specialized function of the colonic mucosa

31 March 2020

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Sulfur reduction by human erythrocytes

31 March 2020

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Sulfur: its clinical and toxicologic aspects

31 March 2020

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Trafficking in persulfides: delivering sulfur in biosynthetic pathways

31 March 2020

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Iron-sulfur clusters: ever-expanding roles.

31 March 2020

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Assay methods and biological roles of labile sulfur in animal tissues

31 March 2020

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Hydrogen sulfide induces calcium waves in astrocytes.

31 March 2020

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Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells

31 March 2020

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Hydrogen sulfide induces serum-independent cell cycle entry in nontransformed rat intestinal epithelial cells.

31 March 2020

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Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1

31 March 2020

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Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide

31 March 2020

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Hydrogen sulfide protects colon cancer cells from chemopreventative agent beta-phenylethyl isothiocyanate induced apoptosis

31 March 2020

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Hydrogen sulfide protects neurons from oxidative stress

31 March 2020

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Hydrogen sulfide protects HT22 neuronal cells from oxidative stress

31 March 2020

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The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'?

31 March 2020

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Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?

31 March 2020

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Effects of hydrogen sulfide on homocysteine-induced oxidative stress in vascular smooth muscle cells

31 March 2020

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Hydrogen sulfide prevents apoptosis of human PMN via inhibition of p38 and caspase 3.

31 March 2020

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Hydrogen sulfide-induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells.

31 March 2020

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Molecular mechanisms of hydrogen sulfide toxicity

31 March 2020

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Cytoprotective and anti-inflammatory effects of hydrogen sulfide in macrophages and mice.

31 March 2020

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Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol

31 March 2020

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Impact of hydrogen sulfide on carbon monoxide/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension

31 March 2020

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Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications

31 March 2020

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Hydrogen sulfide potentiates interleukin-1beta-induced nitric oxide production via enhancement of extracellular signal-regulated kinase activation in rat vascular smooth muscle cells

31 March 2020

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The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener

31 March 2020

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Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms

31 March 2020

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L-cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter

31 March 2020

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Direct inhibition of endothelial nitric oxide synthase by hydrogen sulfide: contribution to dual modulation of vascular tension

31 March 2020

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Hydrogen sulfide mediates vasoactivity in an O2-dependent manner

31 March 2020

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Hydrogen sulfide mediates hypoxia-induced relaxation of trout urinary bladder smooth muscle.

31 March 2020

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Role of endothelium-derived nitric oxide in the regulation of blood pressure

31 March 2020

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Effects of NG-nitro-L-arginine and L-arginine on regional cerebral blood flow in the cat

31 March 2020

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Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide?

31 March 2020

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Hydrogen sulfide: Effects on avian respiratory control and intrapulmonary CO2 receptors

31 March 2020

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Interactions of sulphide and other ligands with cytochrome c oxidase. An electron-paramagnetic-resonance study

31 March 2020

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Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidase

31 March 2020

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Cell biology: Power games

31 March 2020

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Adaptative metabolic response of human colonic epithelial cells to the adverse effects of the luminal compound sulfide.

31 March 2020

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H2S induces a suspended animation-like state in mice

31 March 2020

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Effects of hydrogen sulfide exposure on lung mitochondrial respiratory chain enzymes in rats

31 March 2020

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Inhibition of respiratory and bioenergetic mechanisms by hydrogen sulfide in mammalian brain.

31 March 2020

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Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat.

31 March 2020

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Role of hydrogen sulfide in acute pancreatitis and associated lung injury

31 March 2020

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Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis

31 March 2020

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Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia

31 March 2020

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Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse

31 March 2020

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Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse.

31 March 2020

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Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis

31 March 2020

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A sensitive gas chromatographic method for determination of protein-associated sulfur.

31 March 2020

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High performance liquid chromatographic determination of bound sulfide and sulfite and thiosulfate at their low levels in human serum by pre-column fluorescence derivatization with monobromobimane

31 March 2020

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Determination of bound sulfur in serum by gas dialysis/high-performance liquid chromatography

31 March 2020

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Active site-directed inactivation of cystathionine gamma-synthetase and glutamic pyruvic transaminase by propargylglycine

31 March 2020

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The smooth muscle relaxant effect of hydrogen sulphide in vitro: evidence for a physiological role to control intestinal contractility

31 March 2020

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Vinylglycine and propargylglycine: complementary suicide substrates for L-amino acid oxidase and D-amino acid oxidase

31 March 2020

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Inhibition of ATP-activated potassium channels exerts pressor effects and improves survival in a rat model of severe hemorrhagic shock

31 March 2020

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The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat

31 March 2020

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Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats.

31 March 2020

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Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes.

31 March 2020

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Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs

31 March 2020

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Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation

31 March 2020

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Role of hydrogen sulfide in the cardioprotection caused by ischemic preconditioning in the rat heart and cardiac myocytes.

31 March 2020

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Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels.

31 March 2020

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Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels

31 March 2020

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5-Amino-2-hydroxybenzoic Acid 4-(5-Thioxo-5H-[1,2]dithiol-3yl)-phenyl Ester (ATB-429), a Hydrogen Sulfide-Releasing Derivative of Mesalamine, Exerts Antinociceptive Effects in a Model of Postinflammatory Hypersensitivity

31 March 2020

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Hydrogen sulfide is a mediator of cerebral ischemic damage.

31 March 2020

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Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative

31 March 2020

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Oxygen deprivation causes suspended animation in the zebrafish embryo

31 March 2020

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Dephosphorylation of cell cycle-regulated proteins correlates with anoxia-induced suspended animation in Caenorhabditis elegans

31 March 2020

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Suspended Animation in C. elegans Requires the Spindle Checkpoint

31 March 2020

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Carbon monoxide-induced suspended animation protects against hypoxic damage in Caenorhabditis elegans

31 March 2020

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Buying time in suspended animation

31 March 2020

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Natural resistance to liver cold ischemia-reperfusion injury associated with the hibernation phenotype

31 March 2020

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Ex vivo application of carbon monoxide in University of Wisconsin solution to prevent intestinal cold ischemia/reperfusion injury

31 March 2020

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Induction of carbon monoxide in donor animals prior to organ procurement reduces graft immunogenicity and inhibits chronic allograft dysfunction.

31 March 2020

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Suspended animation-like state protects mice from lethal hypoxia

31 March 2020

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Hypothermia as a mechanism for drug-induced resistance to hypoxia.

31 March 2020

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Infusion of sodium sulfide improves myocardial and endothelial function in a canine model of cardiopulmonary bypass.

31 March 2020

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Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries

31 March 2020

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ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart

31 March 2020

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Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning

31 March 2020

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Limitation of infarct size in the rabbit by ischaemic preconditioning is reversible with glibenclamide.

31 March 2020

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A novel peroxynitrite decomposer catalyst (FP-15) reduces myocardial infarct size in an in vivo peroxynitrite decomposer and acute ischemia-reperfusion in pigs

31 March 2020

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NO-naproxen vs. naproxen: ulcerogenic, analgesic and anti-inflammatory effects

31 March 2020

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Hydrogen sulfide inhibits human platelet aggregation

31 March 2020

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A comparison of the effects of L-NAME, 7-NI and L-NIL on carrageenan-induced hindpaw oedema and NOS activity

31 March 2020

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Nitric oxide-induced inhibition of mouse paw edema: involvement of soluble guanylate cyclase and potassium channels.

31 March 2020

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Hyperhomocysteinemia due to cystathionine beta synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice

31 March 2020

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Treatment of sepsis and septic shock: is there a light at the end of the tunnel?

31 March 2020

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Inhaled nitric oxide therapy in children

31 March 2020

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Recent advances in the treatment of pulmonary hypertension

31 March 2020

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A critical review of the literature on hydrogen sulfide toxicity

31 March 2020

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Proceedings of the Hydrogen Sulfide Health Research and Risk Assessment Symposium October 31-November 2, 2000

31 March 2020

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Toxicology of Hydrogen Sulfide

31 March 2020

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Hydrogen sulfide: clandestine microbial messenger?

31 March 2020

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Peracute toxic effects of inhaled hydrogen sulfide and injected sodium hydrosulfide on the lungs of rats

31 March 2020

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Differential sensitivity of lung and brain to sulfide exposure: a peripheral mechanism for apnea.

31 March 2020

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Respiratory tract toxicity of inhaled hydrogen sulfide in Fischer-344 rats, Sprague-Dawley rats, and B6C3F1 mice following subchronic (90-day) exposure.

31 March 2020

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Olfactory mucosal necrosis in male CD rats following acute inhalation exposure to hydrogen sulfide: reversibility and the possible role of regional metabolism.

31 March 2020

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Physiological effects of hydrogen sulfide inhalation during exercise in healthy men

31 March 2020

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Effects of 5 ppm hydrogen sulfide inhalation on biochemical properties of skeletal muscle in exercising men and women.

31 March 2020

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Hydrogen sulfide and reduced-sulfur gases adversely affect neurophysiological functions.

31 March 2020

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Monoamine oxidase inhibition as a sequel of hydrogen sulfide intoxication: increases in brain catecholamine and 5-hydroxytryptamine levels

31 March 2020

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Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice

31 March 2020

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Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways

31 March 2020

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Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation: correlation with tissue sulfide concentrations in the rat brain, liver, lung, and nasal epithelium.

31 March 2020

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Fertility and developmental neurotoxicity effects of inhaled hydrogen sulfide in Sprague-Dawley rats.

31 March 2020

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Evidence that hydrogen sulfide is a genotoxic agent.

31 March 2020

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The usefulness of thiosulfate as an indicator of hydrogen sulfide poisoning: three cases

31 March 2020

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Acute hydrogen sulfide poisoning. Demonstration of selective uptake of sulfide by the brainstem by measurement of brain sulfide levels

31 March 2020

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Dithiothreitol liberates non-acid labile sulfide from brain tissue of H2S-poisoned animals

31 March 2020

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Local adenovirus-mediated transfer of human endothelial nitric oxide synthase reduces luminal narrowing after coronary angioplasty in pigs

31 March 2020

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Adenoviral-mediated transfer of the human endothelial nitric oxide synthase gene reduces acute hypoxic pulmonary vasoconstriction in rats

31 March 2020

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Vascular gene transfer of the human inducible nitric oxide synthase: characterization of activity and effects on myointimal hyperplasia.

31 March 2020

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Cysteine metabolism and whole blood glutathione synthesis in septic pediatric patients

31 March 2020

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Sulfhemoglobinemia. Clinical and molecular aspects

31 March 2020

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Differentiation of the roles of sulfide oxidase and rhodanese in the detoxification of sulfide by the colonic mucosa

31 March 2020

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H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation

31 March 2020

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Effect of endogenous nitric oxide on mitochondrial respiration of rat hepatocytes in vitro and in vivo

31 March 2020

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Nitric oxide. An important signaling mechanism between vascular endothelium and parenchymal cells in the regulation of oxygen consumption.

31 March 2020

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Sulfide, the first inorganic substrate for human cells

31 March 2020

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Oxidative stress-dependent conversion of hydrogen sulfide to sulfite by activated neutrophils

31 March 2020

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Sulfite induces adherence of polymorphonuclear neutrophils to immobilized fibrinogen through activation of Mac-1 beta2-integrin (CD11b/CD18).

31 March 2020

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Activation of human neutrophils by the pollutant sodium sulfite: effect on cytokine production, chemotaxis, and cell surface expression of cell adhesion molecules

31 March 2020

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Activation of human epithelial lung a549 cells by the pollutant sodium sulfite: enhancement of neutrophil adhesion

31 March 2020

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Sulfite-mediated oxidative stress in kidney cells

31 March 2020

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Enhancement of benzo[a]pyrene diol epoxide mutagenicity by sulfite in a mammalian test system

31 March 2020

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The mutagenicity of sodium bisulfite on base-substitution strains of Salmonella typhimurium.

31 March 2020

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Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide

31 March 2020

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Hydrogen sulfide and carbon monoxide are in synergy with each other in the pathogenesis of recurrent febrile seizures.

31 March 2020

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Impact of L-arginine on hydrogen sulfide/cystathionine-gamma-lyase pathway in rats with high blood flow-induced pulmonary hypertension.

31 March 2020

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Hydrogen sulfide downregulates the aortic L-arginine/nitric oxide pathway in rats

31 March 2020

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Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation

31 March 2020

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Fecal Hydrogen Sulfide Production in Ulcerative Colitis

31 March 2020

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Bismuth subsalicylate markedly decreases hydrogen sulfide release in the human colon

31 March 2020

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Binding of hydrogen sulfide by bismuth does not prevent dextran sulfate-induced colitis in rats

31 March 2020

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Hydrogen sulphide regulates intracellular pH in vascular smooth muscle cells

31 March 2020

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Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function

31 March 2020

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Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats

31 March 2020

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Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways

31 March 2020

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The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation

31 March 2020

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Hydrogen sulfide enhances ulcer healing in rats

31 March 2020

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A protective role of hydrogen sulfide against oxidative stress in rat gastric mucosal epithelium

31 March 2020

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S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway

31 March 2020

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Hydrogen sulfide mediates the vasoactivity of garlic

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD2425

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17 August 2017

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PubMed ID

17948022