(Q36979907)

English

Motivated behaviors and levels of 3α,5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats

scientific article published on May 2013

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scholarly article

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Europe PubMed Central

PMC publication ID

17 August 2017

Motivated behaviors and levels of 3α,5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats (English)

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Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Cheryl Anne Frye

1

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Europe PubMed Central

PMC publication ID

17 August 2017

Carolyn J Koonce

2

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Europe PubMed Central

PMC publication ID

17 August 2017

Alicia A Walf

3

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Europe PubMed Central

PMC publication ID

17 August 2017

Jamie C Rusconi

4

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Europe PubMed Central

PMC publication ID

17 August 2017

publication date

1 May 2013

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Europe PubMed Central

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17 August 2017

number of pages

15

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The Journal of Sexual Medicine

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Europe PubMed Central

PMC publication ID

17 August 2017

10

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Europe PubMed Central

PMC publication ID

17 August 2017

7

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Europe PubMed Central

PMC publication ID

17 August 2017

1692-1706

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Europe PubMed Central

PMC publication ID

17 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3700579/fullTextXML

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I. Levels of 5α-reduced progesterone metabolite in the midbrain account for variability in reproductive behavior of middle-aged female rats

1 reference

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Progesterone turnover to its 5α-reduced metabolites in the ventral tegmental area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female rats

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Estrogen is necessary for 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats

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Exploratory, anti-anxiety, social, and sexual behaviors of rats in behavioral estrus is attenuated with inhibition of 3alpha,5alpha-THP formation in the midbrain ventral tegmental area

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Infusions of 3alpha,5alpha-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3alpha,5alpha-THP in midbrain, hippocampus, diencephalon, and cortex of female rats

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The neurosteroids, progesterone and 3alpha,5alpha-THP, enhance sexual motivation, receptivity, and proceptivity in female rats

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Identifiers

10.1111/JSM.12173

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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