(Q36982767)

English

Application of structural dynamic approaches provide novel insights into the enzymatic mechanism of the tumor necrosis factor-alpha-converting enzyme

scientific article published on 26 September 2007

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

1 reference

Europe PubMed Central

Application of structural dynamic approaches provide novel insights into the enzymatic mechanism of the tumor necrosis factor-alpha-converting enzyme (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Irit Sagi

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Marcos E Milla

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

language of work or name

0 references

publication date

26 September 2007

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Analytical Biochemistry

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

372

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

1-10

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Alpha-secretase activation--an approach to Alzheimer's disease therapy

1 reference

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29 September 2017

Neutron Laue macromolecular crystallography.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

NMR residual dipolar couplings as probes of biomolecular dynamics

1 reference

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29 September 2017

The TACE zymogen: re-examining the role of the cysteine switch

1 reference

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Extended subnanosecond structural dynamics of myoglobin revealed by Laue crystallography

1 reference

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29 September 2017

A structural model for unfolded proteins from residual dipolar couplings and small-angle x-ray scattering.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Identification of slow correlated motions in proteins using residual dipolar and hydrogen-bond scalar couplings.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Advances in kinetic protein crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Shedding light on ADAM metalloproteinases

1 reference

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Regulation of ADAM12 cell-surface expression by protein kinase C epsilon

1 reference

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29 September 2017

Therapeutic benefits from targeting of ADAM family members

1 reference

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29 September 2017

Small-angle scattering: a view on the properties, structures and structural changes of biological macromolecules in solution

1 reference

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29 September 2017

Proteases as drug targets

1 reference

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29 September 2017

ADAMs: modulators of cell–cell and cell–matrix interactions

1 reference

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29 September 2017

A perspective on enzyme catalysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Biochemical properties and functions of membrane-anchored metalloprotease-disintegrin proteins (ADAMs)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Protein ectodomain shedding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Catalytic mechanism of matrix metalloproteinases: two-layered ONIOM study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Functional and biochemical characterization of ADAMs and their predicted role in protein ectodomain shedding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

The Sequence of the Human Genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Cloning and characterization of ADAM28: evidence for autocatalytic pro-domain removal and for cell surface localization of mature ADAM28

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

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Kinetic stability as a mechanism for protease longevity

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29 September 2017

Adamalysins. A family of metzincins including TNF-alpha converting enzyme (TACE).

1 reference

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29 September 2017

Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity

1 reference

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Matrix metalloproteinases: structures, evolution, and diversification

1 reference

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29 September 2017

Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

1 reference

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29 September 2017

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

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The prosegment-subtilisin BPN' complex: crystal structure of a specific 'foldase'

1 reference

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29 September 2017

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

Catalysis of a protein folding reaction: mechanistic implications of the 2.0 A structure of the subtilisin-prodomain complex

1 reference

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29 September 2017

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1 reference

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Shock and tissue injury induced by recombinant human cachectin

1 reference

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29 September 2017

Tumor necrosis, cachexia, shock, and inflammation: a common mediator

1 reference

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29 September 2017

Tumor necrosis factor (TNF).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

29 September 2017

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family

1 reference

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Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation

1 reference

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Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis

1 reference

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Human cytomegalovirus-stimulated peripheral blood mononuclear cells induce HIV-1 replication via a tumor necrosis factor-alpha-mediated mechanism

1 reference

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29 September 2017

Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor

1 reference

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29 September 2017

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1 reference

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29 September 2017

Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain

1 reference

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1 reference

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27 June 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

27 June 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

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A protein-folding reaction under kinetic control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

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Chaperone-like properties of the prodomain of TNFalpha-converting enzyme (TACE) and the functional role of its cysteine switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

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Local dynamic amplitudes on the protein backbone from dipolar couplings: toward the elucidation of slower motions in biomolecules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

4 September 2018

Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-alpha-converting enzyme and matrix metalloproteinases despite their high structural similarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

4 September 2018

Active site electronic structure and dynamics during metalloenzyme catalysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

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Benzodiazepine inhibitors of the MMPs and TACE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

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Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

4 September 2018

Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

4 September 2018

N-hydroxyformamide peptidomimetics as TACE/matrix metalloprotease inhibitors: oral activity via P1' isobutyl substitution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

4 September 2018

Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

4 September 2018

Insight into the complex and dynamic process of activation of matrix metalloproteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

4 September 2018

Activation mechanisms of matrix metalloproteinases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2254313

4 September 2018

Remodeling MMPIs

1 reference

https://pubmed.ncbi.nlm.nih.gov/17963710

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined use of XAFS and crystallography for studying protein-ligand interactions in metalloproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17963710

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADAM12 Is a Four-leafed Clover

1 reference

https://pubmed.ncbi.nlm.nih.gov/17963710

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug evaluation: apratastat, a novel TACE/MMP inhibitor for rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17963710

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Snapshots of the Reaction Mechanism of Matrix Metalloproteinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17963710

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17963710

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Model-Free Approach to the Dynamic Interpretation of Residual Dipolar Couplings in Globular Proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17963710

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of tumor necrosis factor-alpha (TNF-alpha) production and arthritis in the rat by GW3333, a dual inhibitor of TNF-alpha-converting enzyme and matrix metalloproteinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17963710

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/17963710

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of tumour necrosis factor-α precursor by metalloproteinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17963710

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3

1 reference

https://pubmed.ncbi.nlm.nih.gov/17963710

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An essential role for ectodomain shedding in mammalian development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17963710

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Human ADAM 12 Protease by the Prodomain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17963710

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.AB.2007.07.037

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

0 references

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