(Q37008187)

17 August 2017

Finding a way out: lymphocyte egress from lymphoid organs (English)

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17 August 2017

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17 August 2017

Jason G Cyster

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PubMed ID

18026082

17 August 2017

language of work or name

English

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publication date

1 December 2007

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17 August 2017

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17 August 2017

8

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17 August 2017

1295-1301

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17 August 2017

12

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The lymphocyte--a disgraceful gap in medical knowledge.

17 August 2017

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7 January 2021

Homing and cellular traffic in lymph nodes

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7 January 2021

Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs

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7 January 2021

A pertussis toxin-sensitive process controls thymocyte emigration

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7 January 2021

Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

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7 January 2021

FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity

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7 January 2021

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

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7 January 2021

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.

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7 January 2021

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

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7 January 2021

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

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7 January 2021

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

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7 January 2021

Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration

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7 January 2021

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

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7 January 2021

Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit

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7 January 2021

Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate

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7 January 2021

Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.

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7 January 2021

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

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7 January 2021

Tipping the gatekeeper: S1P regulation of endothelial barrier function

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7 January 2021

Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses

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7 January 2021

Kruppel-like factor 2 regulates thymocyte and T-cell migration

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7 January 2021

A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress

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7 January 2021

Defective chemokine-directed lymphocyte migration and development in the absence of Rho guanosine diphosphate-dissociation inhibitors alpha and beta.

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7 January 2021

Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1.

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7 January 2021

Enzymes of sphingolipid metabolism: from modular to integrative signaling

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7 January 2021

Sphingosine-1-phosphate: an enigmatic signalling lipid

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7 January 2021

Point-counterpoint of sphingosine 1-phosphate metabolism

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7 January 2021

Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients

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7 January 2021

Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate

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7 January 2021

Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.

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7 January 2021

Essential role for sphingosine kinases in neural and vascular development

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7 January 2021

Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes

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7 January 2021

Role of ABCC1 in export of sphingosine-1-phosphate from mast cells

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7 January 2021

Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner.

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7 January 2021

LKLF: A transcriptional regulator of single-positive T cell quiescence and survival

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7 January 2021

CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs

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7 January 2021

A potential role for CD69 in thymocyte emigration

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7 January 2021

The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression

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7 January 2021

Systematic identification of regulatory proteins critical for T-cell activation

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7 January 2021

Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist

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7 January 2021

Antigen-induced selective recruitment of circulating lymphocytes

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7 January 2021

The kinetics of antigen-reactive cells during lymphocyte recruitment.

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7 January 2021

Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells

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7 January 2021

Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription

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7 January 2021

Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1.

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7 January 2021

Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes

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7 January 2021

Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism

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7 January 2021

Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

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7 January 2021

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

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7 January 2021

Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists

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7 January 2021

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

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7 January 2021

Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor

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7 January 2021

Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics

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7 January 2021

The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors

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7 January 2021

The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.

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7 January 2021

Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin.

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7 January 2021

Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone.

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7 January 2021

Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor.

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7 January 2021

The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis

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7 January 2021

Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis

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7 January 2021

Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice

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7 January 2021

Sphingosine-1-phosphate mediates migration of mature dendritic cells.

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7 January 2021

Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function

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7 January 2021

The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cells.

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7 January 2021

Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.

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7 January 2021

FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells.

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7 January 2021

The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity.

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7 January 2021

Thymic microvascular system.

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7 January 2021

Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus

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7 January 2021

FTY720 preferentially depletes naive T cells from peripheral and lymphoid organs

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7 January 2021

Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720.

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7 January 2021

Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.

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7 January 2021

Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production.

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7 January 2021

FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory.

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7 January 2021

FTY720 suppresses humoral immunity by inhibiting germinal center reaction

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7 January 2021

Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement

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7 January 2021

Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells

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7 January 2021

Oral fingolimod (FTY720) for relapsing multiple sclerosis

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7 January 2021

Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology

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7 January 2021

Lysophospholipid receptors: signaling and biology

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7 January 2021

Identifiers

DOI

10.1038/NI1545

1 reference

17 August 2017

1 reference

PubMed ID

18026082