(Q37012643)

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Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem

scientific article published on 09 May 2008

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18555494%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18555494%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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9 January 2020

author name string

James Auta

1

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9 January 2020

Francesco Impagnatiello

2

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9 January 2020

Alessandro Guidotti

4

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9 January 2020

Erminio Costa

5

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9 January 2020

publication date

9 May 2008

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9 January 2020

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6

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Neuropharmacology

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9 January 2020

55

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9 January 2020

2

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9 January 2020

148-153

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9 January 2020

Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABA

1 reference

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29 September 2017

L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors.

1 reference

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GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon.

1 reference

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29 September 2017

GABAA receptor subtypes: any clues to the mechanism of benzodiazepine dependence?

1 reference

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GABAergic cortical neuron chromatin as a putative target to treat schizophrenia vulnerability.

1 reference

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29 September 2017

Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics

1 reference

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29 September 2017

Identification of a Novel, Selective GABAAα5 Receptor Inverse Agonist Which Enhances Cognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

Anxiogenic-like activity of L-655,708, a selective ligand for the benzodiazepine site of GABA(A) receptors which contain the alpha-5 subunit, in the elevated plus-maze test

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

GABAA receptors and benzodiazepines: a role for dendritic resident subunit mRNAs

1 reference

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29 September 2017

Contribution of the alpha1-GABA(A) receptor subtype to the pharmacological actions of benzodiazepine site inverse agonists

1 reference

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29 September 2017

Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

Basic pharmacologic mechanisms involved in benzodiazepine tolerance and withdrawal

1 reference

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29 September 2017

Chronic benzodiazepine treatment of cells expressing recombinant GABA(A) receptors uncouples allosteric binding: studies on possible mechanisms

1 reference

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29 September 2017

GABA(A)-receptor subtypes: a new pharmacology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

Molecular targets for the myorelaxant action of diazepam.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

Mechanism of action of the hypnotic zolpidem in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

Imidazenil prevention of alprazolam-induced acquisition deficit in patas monkeys is devoid of tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

[3H]L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the alpha 5 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2

1 reference

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29 September 2017

Benzodiazepines on trial: a research strategy for their rehabilitation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

Modifications of gamma-aminobutyric acidA receptor subunit expression in rat neocortex during tolerance to diazepam.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

Imidazenil, a partial positive allosteric modulator of GABAA receptors, exhibits low tolerance and dependence liabilities in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

U-90042, a sedative/hypnotic compound that interacts differentially with the GABAA receptor subtypes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

Protracted treatment with diazepam increases the turnover of putative endogenous ligands for the benzodiazepine/beta-carboline recognition site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

Autoradiographic localization of benzodiazepine receptor downregulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

Benzodiazepines: use, abuse, and consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

29 September 2017

Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

27 June 2018

GABA(A) receptors containing the alpha4-subunit: prevalence, distribution, pharmacology, and subunit architecture in situ

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

27 June 2018

Tolerance to diazepam and changes in GABA(A) receptor subunit expression in rat neocortical areas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

27 June 2018

Reversible modification of GABAA receptor subunit mRNA expression during tolerance to diazepam-induced cognition dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

27 June 2018

Chronic administration of an anticonvulsant dose of imidazenil fails to induce tolerance of GABAA receptor function in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

27 June 2018

Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

27 June 2018

Chronic diazepam treatment produces regionally specific changes in GABA-stimulated chloride influx.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

27 June 2018

Effects of continuous diazepam administration on GABAA subunit mRNA in rat brain.

1 reference

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27 June 2018

GABAA receptor subunit mRNA levels are differentially influenced by chronic FG 7142 and diazepam exposure

1 reference

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27 June 2018

Reversal of pathological pain through specific spinal GABAA receptor subtypes.

1 reference

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4 September 2018

GABA receptors containing the alpha5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear.

1 reference

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4 September 2018

Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice.

1 reference

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4 September 2018

Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice.

1 reference

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Molecular and neuronal substrate for the selective attenuation of anxiety.

1 reference

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4 September 2018

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2601598

4 September 2018

Lack of anticonvulsant tolerance and benzodiazepine receptor down regulation with imidazenil in rats.

1 reference

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4 September 2018

Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors

1 reference

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Laminar compartmentalization of GABAA-receptor subtypes in the spinal cord: an immunohistochemical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18555494

12 December 2020

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10.1016/J.NEUROPHARM.2008.05.002

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9 January 2020

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9 January 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18555494%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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