(Q37017190)

English

Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer.

scientific article published on 20 May 2016

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scholarly article

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2 April 2020

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Europe PubMed Central

Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer (English)

1 reference

Europe PubMed Central

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2 April 2020

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2 April 2020

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Carter Van Waes

2

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2 April 2020

Clint T Allen

3

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20 May 2016

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2 April 2020

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59-70

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2 April 2020

OX40, PD-1 and CTLA-4 are selectively expressed on tumor-infiltrating T cells in head and neck cancer

1 reference

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Anti-Tumor Immunity in Head and Neck Cancer: Understanding the Evidence, How Tumors Escape and Immunotherapeutic Approaches

1 reference

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OX40 signaling in head and neck squamous cell carcinoma: Overcoming immunosuppression in the tumor microenvironment

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Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy

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Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer.

1 reference

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1 reference

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1 reference

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CXCR3+ T regulatory cells selectively accumulate in human ovarian carcinomas to limit type I immunity.

1 reference

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

1 reference

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The clinical implications of antitumor immunity in head and neck cancer

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Galectin-1: a link between tumor hypoxia and tumor immune privilege

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Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

29 September 2017

Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

29 September 2017

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

29 September 2017

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

29 September 2017

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

29 September 2017

Growth regulated oncogene-alpha expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC receptor-2 dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

29 September 2017

The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

29 September 2017

The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1alpha, IL-6, GM-CSF, and KC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

29 September 2017

Mechanisms of immune suppression in patients with head and neck cancer: presence of CD34(+) cells which suppress immune functions within cancers that secrete granulocyte-macrophage colony-stimulating factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

29 September 2017

A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

29 September 2017

Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

29 September 2017

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

29 September 2017

Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

27 June 2018

Exomics and immunogenics: Bridging mutational load and immune checkpoints efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

27 June 2018

Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

Phase 1 and pharmacological trial of OPB-31121, a signal transducer and activator of transcription-3 inhibitor, in patients with advanced hepatocellular carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

Immunosuppressive activity of CD14+ HLA-DR- cells in squamous cell carcinoma of the head and neck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

T regulatory type 1 cells in squamous cell carcinoma of the head and neck: mechanisms of suppression and expansion in advanced disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25- lymphocytes is thymus and proliferation independent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

Overexpression of transforming growth factor beta1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

Increased aberrance of cytokine expression in plasma of patients with more advanced squamous cell carcinoma of the head and neck.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

Cytokines IL-1α, IL-6, and GM-CSF constitutively secreted by oral squamous carcinoma induce down-regulation of CD80 costimulatory molecule expression: restoration by interferon γ

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 September 2018

Prognostic Value of Tumor-Infiltrating CD4+ T-Cell Subpopulations in Head and Neck Cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 December 2018

Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912416

4 December 2018

Natural killer cell activity and head and neck cancer: a clinical assessment

1 reference

https://pubmed.ncbi.nlm.nih.gov/27215705

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural regulatory T cells and de novo-induced regulatory T cells contribute independently to tumor-specific tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/27215705

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27215705

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/27215705

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/27215705

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Priming of naive T cells inside tumors leads to eradication of established tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/27215705

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engagement of the OX-40 receptor in vivo enhances antitumor immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27215705

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased presence of CD34+ cells in the peripheral blood of head and neck cancer patients and their differentiation into dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27215705

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dendritic Cell Vaccination in Combination with Anti-CD25 Monoclonal Antibody Treatment: A Phase I/II Study in Metastatic Melanoma Patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/27215705

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pools of programmed death-ligand within the oral cavity tumor microenvironment: Variable alteration by targeted therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/27215705

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/27215705

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor-associated macrophages and the profile of inflammatory cytokines in oral squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/27215705

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.ORALONCOLOGY.2016.05.002

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27215705%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27215705%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27215705%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

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