(Q37023517)

English

Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model.

scientific article published on December 2008

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scholarly article

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Europe PubMed Central

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17 January 2020

Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding characterization at D2/D3 receptors and elucidation of a pharmacophore model (English)

1 reference

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17 January 2020

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Prashant S Kharkar

2

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17 January 2020

5

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17 January 2020

author name string

Dennis A Brown

1

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17 January 2020

Ingrid Parrington

3

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17 January 2020

Maarten E A Reith

4

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17 January 2020

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1 December 2008

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17 January 2020

Journal of Medicinal Chemistry

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17 January 2020

51

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17 January 2020

24

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17 January 2020

7806-7819

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17 January 2020

The dopamine D3/D2 agonist (+)-PD-128,907 [(R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol)] protects against acute and cocaine-kindled seizures in mice: further evidence for the involvement of D3 receptors.

1 reference

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Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity.

1 reference

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29 September 2017

Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with [...]

1 reference

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1 reference

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Synthesis and biological characterization of novel hybrid 7-[[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino]-5,6,7,8-tetrahydro-naphthalen-2-ol and their heterocyclic bioisosteric analogues for dopamine D2 and D3 receptors.

1 reference

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29 September 2017

A novel series of hybrid compounds derived by combining 2-aminotetralin and piperazine fragments: binding activity at D2 and D3 receptors

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Dopamine receptors--physiological understanding to therapeutic intervention potential

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Role of conserved serine residues in the interaction of agonists with D3 dopamine receptors

1 reference

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29 September 2017

Mapping of dopamine D3 receptor binding site by pharmacological characterization of mutants expressed in CHO cells with the Semliki Forest virus system

1 reference

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Dopamine receptors: from structure to function

2 references

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29 September 2017

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4 September 2018

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

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29 September 2017

N-Alkylated 2-aminotetralins: central dopamine-receptor stimulating activity

1 reference

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29 September 2017

Distribution of dopamine D3 receptor expressing neurons in the human forebrain: comparison with D2 receptor expressing neurons

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27 June 2018

Biosynthesis, structure, and function of neuromelanin and its relation to Parkinson's disease: a critical update

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27 June 2018

Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607046

27 June 2018

Conformationally restricted congeners of dopamine derived from octahydrobenzo[g]quinoline and octahydrobenzo[f]quinoline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607046

27 June 2018

N-substituted 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines and 3-phenylpiperidines: effects on central dopamine and sigma receptors

1 reference

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27 June 2018

Characterization of dopamine receptor subtypes by comparative structure-activity relationships: dopaminomimetic activities and solid state conformation of monohydroxy-1,2,3,4,4a,5,10,10a-octahydrobenz[g]quinolines and its implications for a rotamer-

1 reference

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27 June 2018

Contributions of Conserved Serine Residues to the Interactions of Ligands with Dopamine D2 Receptors

1 reference

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27 June 2018

Synthesis and pharmacology of some 2-aminotetralins. Dopamine receptor agonists

1 reference

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27 June 2018

Cerebral dopamine agonist properties of some 2-aminotetralin derivatives after peripheral and intracerebral administration

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27 June 2018

The conformation of dopamine at its receptor: binding of monohydroxy-2-aminotetralin enantiomers and positional isomers

1 reference

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27 June 2018

Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.

1 reference

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Synthesis and dopaminergic activity of (+/-)-, (+)-, and (-)-2-dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resolved monophenolic 2-aminotetralins and 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines: structural and stereochemical considerations for centrally acting pre- and postsynaptic dopamine-receptor agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/19053758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological aspects of R-(+)-7-OH-DPAT, a putative dopamine D3 receptor ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/19053758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM8008629

1 reference

Europe PubMed Central

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17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19053758%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19053758%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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