(Q37023836)

English

Post-injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury

scientific article published on 08 September 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Post-injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

traumatic brain injury

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author name string

S-F Chen

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

C-W Hsu

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

W-H Huang

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

J-Y Wang

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

language of work or name

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publication date

8 September 2008

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

British Journal of Pharmacology

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Europe PubMed Central

PMC publication ID

17 August 2017

155

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

1279-1296

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Baicalein inhibition of oxidative-stress-induced apoptosis via modulation of ERKs activation and induction of HO-1 gene expression in rat glioma cells C6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Experimental models of traumatic brain injury: do we really need to build a better mousetrap?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Regional distribution of fluoro-jade B staining in the hippocampus following traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Motor and cognitive function evaluation following experimental traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Pathophysiology of cerebral ischemia and brain trauma: similarities and differences

1 reference

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29 September 2017

The role of phospholipases, cyclooxygenases, and lipoxygenases in cerebral ischemic/traumatic injuries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

The effects of the cyclosporin A, a P-glycoprotein inhibitor, on the pharmacokinetics of baicalein in the rat: a microdialysis study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Inflammatory response in acute traumatic brain injury: a double-edged sword

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Involvement of inflammatory cytokines in central nervous system injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Cytokines and acute neurodegeneration

1 reference

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29 September 2017

Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats

1 reference

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29 September 2017

Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Potential mechanisms of interleukin-1 involvement in cerebral ischaemia.

1 reference

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29 September 2017

Absence of evidence for the effectiveness of five interventions routinely used in the intensive care management of severe head injury: a systematic review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme-mediated apoptosis

1 reference

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29 September 2017

Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

29 September 2017

Experimental axonal injury triggers interleukin-6 mRNA, protein synthesis and release into cerebrospinal fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

27 June 2018

To what extent have functional studies of ischaemia in animals been useful in the assessment of potential neuroprotective agents?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

27 June 2018

Delayed cytokine expression in rat brain following experimental contusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

27 June 2018

Inhibition of tumor necrosis factor alpha (TNFalpha) activity in rat brain is associated with cerebroprotection after closed head injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

27 June 2018

Closed head injury triggers early production of TNF alpha and IL-6 by brain tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

27 June 2018

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

27 June 2018

Elevation of tumor necrosis factor in head injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

27 June 2018

Recombinant human tumor necrosis factor alpha constricts pial arterioles and increases blood-brain barrier permeability in newborn piglets

1 reference

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27 June 2018

Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

4 September 2018

Lovastatin improves histological and functional outcomes and reduces inflammation after experimental traumatic brain injury.

1 reference

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4 September 2018

Rapid glia expression and release of proinflammatory cytokines in experimental Klebsiella pneumoniae meningoencephalitis

1 reference

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4 September 2018

Baicalein and 12/15-lipoxygenase in the ischemic brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

4 September 2018

Baicalein attenuates methamphetamine-induced loss of dopamine transporter in mouse striatum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

4 September 2018

The effect of traumatic brain injury upon the concentration and expression of interleukin-1beta and interleukin-10 in the rat.

1 reference

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4 September 2018

Effect of interleukin-1 on traumatic brain injury-induced damage to hippocampal neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

4 September 2018

Baicalein prevents 6-hydroxydopamine-induced dopaminergic dysfunction and lipid peroxidation in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

4 September 2018

Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons

1 reference

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4 September 2018

Tumor necrosis factor alpha expression and protein levels after fluid percussion injury in rats: the effect of injury severity and brain temperature.

1 reference

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4 September 2018

Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

4 September 2018

Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

4 September 2018

Time course of cellular pathology after controlled cortical impact injury

1 reference

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4 September 2018

Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

4 September 2018

Novel synthesis of flavonoids of Scutellaria baicalensis Georgi

1 reference

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4 September 2018

Flavonoid baicalein attenuates activation-induced cell death of brain microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

4 September 2018

Administration of either anti-intercellular adhesion molecule-1 or a nonspecific control antibody improves recovery after traumatic brain injury in the rat.

1 reference

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4 September 2018

Hwangryun-Hae-Dok-tang (Huanglian-Jie-Du-Tang) extract and its constituents reduce ischemia-reperfusion brain injury and neutrophil infiltration in rats

1 reference

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4 September 2018

Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice

1 reference

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4 September 2018

Neurobehavioral assessment of outcome following traumatic brain injury in rats: an evaluation of selected measures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

4 September 2018

Effects of baicalein isolated from Scutellaria baicalensis Radix on adhesion molecule expression induced by thrombin and thrombin receptor agonist peptide in cultured human umbilical vein endothelial cells

1 reference

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4 September 2018

Endothelial cell activation following moderate traumatic brain injury

1 reference

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4 September 2018

Interleukin-1 receptor antagonist attenuates regional neuronal cell death and cognitive dysfunction after experimental brain injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

4 September 2018

Early neuronal expression of tumor necrosis factor-alpha after experimental brain injury contributes to neurological impairment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607198

4 September 2018

Interleukin-6 and its soluble receptor in serum and cerebrospinal fluid after cerebral trauma

1 reference

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4 September 2018

Analysis of inhibitory effects of scutellariae radix and baicalein on prostaglandin E2 production in rat C6 glioma cells.

1 reference

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4 September 2018

Soluble ICAM-1 in CSF coincides with the extent of cerebral damage in patients with severe traumatic brain injury

1 reference

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4 September 2018

Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand

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4 September 2018

Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury.

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4 September 2018

IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to IL-6, TNF-alpha, TGF-beta1 and blood-brain barrier function

1 reference

https://pubmed.ncbi.nlm.nih.gov/18776918

12 December 2020

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Effects of qing-fei-tang (seihai-to) and baicalein, its main component flavonoid, on lucigenin-dependent chemiluminescence and leukotriene B4 synthesis of human alveolar macrophages

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https://pubmed.ncbi.nlm.nih.gov/18776918

12 December 2020

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Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors

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https://pubmed.ncbi.nlm.nih.gov/18776918

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Free radical scavenging action of baicalein

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https://pubmed.ncbi.nlm.nih.gov/18776918

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Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures

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Intracerebral administration of interleukin-1beta and induction of inflammation, apoptosis, and vasogenic edema

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Identifiers

10.1038/BJP.2008.345

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

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