(Q37035849)

English

Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1.

scientific article published on December 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1. (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Yongxian Zhuang

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

W Keith Miskimins

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

publication date

1 December 2008

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Journal of Molecular Signaling

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

18

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

copyright license

Creative Commons Attribution 4.0 International

1 December 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

1 reference

April 2022 Public Data File from Crossref

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model

1 reference

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The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

1 reference

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29 September 2017

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

1 reference

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Structural basis for AMP binding to mammalian AMP-activated protein kinase

1 reference

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29 September 2017

AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner

1 reference

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29 September 2017

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

1 reference

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Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.

1 reference

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Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

1 reference

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A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

1 reference

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29 September 2017

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

1 reference

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The LKB1 tumor suppressor kinase in human disease

1 reference

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Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines

1 reference

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Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

1 reference

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29 September 2017

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

1 reference

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29 September 2017

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

1 reference

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29 September 2017

The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases

1 reference

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613390

29 September 2017

Metformin and reduced risk of cancer in diabetic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613390

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Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype

1 reference

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29 September 2017

New roles for the LKB1-->AMPK pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613390

29 September 2017

IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613390

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613390

29 September 2017

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613390

29 September 2017

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613390

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

1 reference

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Mitochondrial metabolism and type-2 diabetes: a specific target of metformin

1 reference

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AMP-activated protein kinase, super metabolic regulator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613390

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The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613390

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The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma

1 reference

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29 September 2017

Role of AMP-activated protein kinase in mechanism of metformin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613390

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

1 reference

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CDK inhibitors: positive and negative regulators of G1-phase progression

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AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside

1 reference

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27 June 2018

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1 reference

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Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin

1 reference

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Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

1 reference

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Prevention of pancreatic cancer induction in hamsters by metformin

1 reference

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4 September 2018

5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19046439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19046439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1750-2187-3-18

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

0 references

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