(Q37066273)

English

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.

scientific article published on 16 October 2008

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18927430%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18927430%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

1

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24 December 2019

author name string

Keith W Kombrinck

2

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24 December 2019

Kathryn E Talmage

3

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24 December 2019

Maureen A Shaw

4

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24 December 2019

David P Witte

5

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24 December 2019

Joni M Ullman

6

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24 December 2019

Sandra J Degen

7

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24 December 2019

William Sun

8

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24 December 2019

Matthew J Flick

9

1 reference

Europe PubMed Central

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24 December 2019

Jay L Degen

10

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24 December 2019

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publication date

16 October 2008

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24 December 2019

1 reference

Europe PubMed Central

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24 December 2019

113

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24 December 2019

3

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24 December 2019

696-704

1 reference

Europe PubMed Central

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24 December 2019

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2628376/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X

1 reference

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Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

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29 September 2017

Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.

1 reference

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29 September 2017

The central role of thrombin in hemostasis

1 reference

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29 September 2017

Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction

1 reference

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29 September 2017

Role of thrombin signalling in platelets in haemostasis and thrombosis

1 reference

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29 September 2017

Association between arterial and intracranial pressures

1 reference

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29 September 2017

PAR3 is a cofactor for PAR4 activation by thrombin

1 reference

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29 September 2017

Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1

1 reference

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29 September 2017

Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice

1 reference

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29 September 2017

Prothrombin deficiency results in embryonic and neonatal lethality in mice

1 reference

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29 September 2017

Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Galphaq

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29 September 2017

Mice lacking factor VII develop normally but suffer fatal perinatal bleeding

1 reference

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29 September 2017

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2628376

29 September 2017

Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V

1 reference

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29 September 2017

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation

1 reference

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29 September 2017

Activation of the zymogen of hepatocyte growth factor activator by thrombin

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Inducible gene targeting in mice

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29 September 2017

Proteolytic action of thrombin is required for electrical activity-dependent synapse reduction

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Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain

1 reference

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29 September 2017

HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells

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Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon

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Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140

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Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

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29 September 2017

Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2.

1 reference

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The development of cardiac fibrosis in low tissue factor mice is gender-dependent and is associated with differential regulation of urokinase plasminogen activator.

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The increasing incidence of anticoagulant-associated intracerebral hemorrhage

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Role of tissue factor in haemostasis, thrombosis, angiogenesis and inflammation: lessons from low tissue factor mice.

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Role of fibrinogen- and platelet-mediated hemostasis in mouse embryogenesis and reproduction

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Thrombin Activatable Fibrinolysis Inhibitor, a Potential Regulator of Vascular Inflammation

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4 September 2018

Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation

1 reference

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Rescue of prothrombin-deficiency by transgene expression in mice.

1 reference

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Participation of protease-activated receptor-1 in thrombin-induced microglial activation

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Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation

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Generation of genetically-altered mice producing very low levels of coagulation factorVII

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Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII

1 reference

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Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice

1 reference

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Identifiers

10.1182/BLOOD-2008-07-169003

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18927430%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18927430%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18927430%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

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