(Q37070370)

18 August 2017

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title

Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression (English)

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18 August 2017

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Kay-Uwe Wagner

1

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18 August 2017

Hallgeir Rui

series ordinal

2

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18 August 2017

publication date

29 January 2008

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Journal of Mammary Gland Biology and Neoplasia

18 August 2017

published in

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18 August 2017

volume

13

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18 August 2017

issue

1

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18 August 2017

page(s)

93-103

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Loss of caveolin-1 causes the hyper-proliferation of intestinal crypt stem cells, with increased sensitivity to whole body gamma-radiation

18 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10911-008-9062-Z

Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10911-008-9062-Z

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10911-008-9062-Z

Stat5a is mandatory for adult mammary gland development and lactogenesis.

21 January 2018

1 reference

12 December 2020

The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development.

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12 December 2020

Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status

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12 December 2020

STAT 5a expression in various lesions of the breast

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12 December 2020

Severe growth hormone insensitivity resulting from total absence of signal transducer and activator of transcription 5b.

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12 December 2020

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

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12 December 2020

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation

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12 December 2020

Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer.

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12 December 2020

IGF-2 is a mediator of prolactin-induced morphogenesis in the breast

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12 December 2020

Transactivating agonists of the EGF receptor require Tyr 845 phosphorylation for induction of DNA synthesis

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12 December 2020

Differential effects of prolactin and src/abl kinases on the nuclear translocation of STAT5B and STAT5A

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12 December 2020

Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland

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12 December 2020

Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation

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12 December 2020

Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6

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12 December 2020

Evaluation of genome-wide chromatin library of Stat5 binding sites in human breast cancer

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12 December 2020

Prolactin as a Chemoattractant for Human Breast Carcinoma

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12 December 2020

Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse

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12 December 2020

Using gene expression arrays to elucidate transcriptional profiles underlying prolactin function

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12 December 2020

Tumors caused by overexpression and forced activation of Stat5 in mammary epithelial cells of transgenic mice are parity-dependent and developed in aged, postestropausal females.

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12 December 2020

Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice

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12 December 2020

Prolactin signaling in mammary gland development.

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12 December 2020

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

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12 December 2020

An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions

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12 December 2020

ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation

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12 December 2020

The Hallmarks of Cancer

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12 December 2020

Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis.

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12 December 2020

Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness

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12 December 2020

PRL activates the cyclin D1 promoter via the Jak2/Stat pathway.

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12 December 2020

Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium

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12 December 2020

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

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12 December 2020

Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation.

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12 December 2020

Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions.

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12 December 2020

Prolactin controls mammary gland development via direct and indirect mechanisms.

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12 December 2020

Functional rescue of Stat5a-null mammary tissue through the activation of compensating signals including Stat5b

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12 December 2020

The Stat family in cytokine signaling

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12 December 2020

The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia

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12 December 2020

Involvement of prolactin in breast cancer: redefining the molecular targets.

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12 December 2020

Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

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12 December 2020

The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells

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12 December 2020

Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response.

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12 December 2020

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

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12 December 2020

Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium

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12 December 2020

Growth signaling and JAK2 association mediated by membrane-proximal cytoplasmic regions of prolactin receptors

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12 December 2020

An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal.

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12 December 2020

Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis

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12 December 2020

Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells

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12 December 2020

Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice

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12 December 2020

Signal transducer and activator of transcription-5 activation and breast cancer prognosis

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12 December 2020

Promotion by prolactin of the growth of human breast neoplasms cultured in vitro in the soft agar clonogenic assay

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12 December 2020

Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless.

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12 December 2020

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue

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12 December 2020

Activation of receptor-associated tyrosine kinase JAK2 by prolactin

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12 December 2020

Spontaneous lesions in aging FVB/N mice

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12 December 2020

Persistent mammary hyperplasia in FVB/N mice

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12 December 2020

Stats: transcriptional control and biological impact

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12 December 2020

Stat5 activation inhibits prolactin-induced AP-1 activity: distinct prolactin-initiated signals in tumorigenesis dependent on cell context.

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12 December 2020

Prolactin as a mitogen in mammary cells

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12 December 2020

Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution

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12 December 2020

Are the TDLU of the human the same as the LA of mice?

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12 December 2020

Loss of Stat5a delays mammary cancer progression in a mouse model.

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12 December 2020

Signaling through the JAK/STAT pathway, recent advances and future challenges

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12 December 2020

Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells

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12 December 2020

Estrogen negatively regulates epidermal growth factor (EGF)-mediated signal transducer and activator of transcription 5 signaling in human EGF family receptor-overexpressing breast cancer cells

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12 December 2020

Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects.

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12 December 2020

Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.

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12 December 2020

Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice

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12 December 2020

Dominant-negative Stat5 inhibits growth and induces apoptosis in T47D-derived tumors in nude mice

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12 December 2020

Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice

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12 December 2020

Spontaneous pituitary abnormalities and mammary hyperplasia in FVB/NCr mice: implications for mouse modeling.

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12 December 2020

Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice

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12 December 2020

The JAK2 V617F mutation in de novo acute myelogenous leukemias.

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12 December 2020

Stat5 in the mammary gland: controlling normal development and cancer

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12 December 2020

Human prolactin receptors are insensitive to mouse prolactin: implications for xenotransplant modeling of human breast cancer in mice.

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12 December 2020

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

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12 December 2020

STAT 5a expression in the breast is maintained in secretory carcinoma, in contrast to other histologic types

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12 December 2020

Genetic ablation of caveolin-1 in mammary epithelial cells increases milk production and hyper-activates STAT5a signaling

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12 December 2020

Pregnancy and stem cell behavior

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12 December 2020

Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers

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12 December 2020

Caveolin-1 inhibits breast cancer growth and metastasis

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12 December 2020

Defining the role of prolactin as an invasion suppressor hormone in breast cancer cells.

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12 December 2020

Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK.

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12 December 2020

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

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12 December 2020

In vivo response-based identification of direct hormone target cell populations using high-density tissue arrays.

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12 December 2020

A road map for those who don't know JAK-STAT

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12 December 2020

Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells.

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12 December 2020

Modulation of signal transducer and activator of transcription 5b activity in breast cancer cells by mutation of tyrosines within the transactivation domain

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12 December 2020

Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene

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12 December 2020

Jak2 is essential for signaling through a variety of cytokine receptors

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12 December 2020

Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression

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12 December 2020

Growth hormone insensitivity associated with a STAT5b mutation

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12 December 2020

Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter

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12 December 2020

Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis

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12 December 2020

Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells.

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12 December 2020

The role of Stat5 in estrogen receptor-positive breast cancer

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12 December 2020

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

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12 December 2020

Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.

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12 December 2020

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium

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12 December 2020

Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation

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12 December 2020

10.1007/S10911-008-9062-Z

Identifiers

DOI

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18 August 2017

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