(Q37074013)

English

Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027

scientific article published on 22 September 2007

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027 (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

0 references

author name string

Shuangjun Lin

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Steven G Van Lanen

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Ben Shen

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

language of work or name

0 references

publication date

22 September 2007

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Journal of the American Chemical Society

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

129

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

41

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

12432-12438

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Nature's inventory of halogenation catalysts: oxidative strategies predominate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Flavin-dependent halogenases involved in secondary metabolism in bacteria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

SyrB2 in syringomycin E biosynthesis is a nonheme FeII alpha-ketoglutarate- and O2-dependent halogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

A novel halogenase gene from the pentachloropseudilin producer Actinoplanes sp. ATCC 33002 and detection of in vitro halogenase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Microbial biosynthesis of halometabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Purification and Partial Characterization of Tryptophan 7-Halogenase (PrnA) from Pseudomonas fluorescens This work was supported by the Deutsche Forschungsgemeinschaft (DFG) through the Graduiertenkolleg "Struktur-Eigenschafts-Beziehungen bei Hetero

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Characterization of a two-component alkanesulfonate monooxygenase from Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

The mechanism and substrate specificity of the NADPH:flavin oxidoreductase from Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

Cloning, sequence analysis, and expression of the Flavobacterium pentachlorophenol-4-monooxygenase gene in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

A single binding mode of activated enediyne C1027 generates two types of double-strand DNA lesions: deuterium isotope-induced shuttling between adjacent nucleotide target sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

29 September 2017

A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

27 June 2018

Mechanism of action of a new macromolecular antitumor antibiotic, C-1027.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

27 June 2018

Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

4 September 2018

Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

4 September 2018

Kinetic Analysis of the 4-Methylideneimidazole-5-one-Containing Tyrosine Aminomutase in Enediyne Antitumor Antibiotic C-1027 Biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

4 September 2018

A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2631410

4 September 2018

Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027

1 reference

https://pubmed.ncbi.nlm.nih.gov/17887753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the aminocarboxycyclopropane-forming enzyme CmaC

1 reference

https://pubmed.ncbi.nlm.nih.gov/17887753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computer modeling analysis for enediyne chromophore-apoprotein complex of macromolecular antitumor antibiotic C-1027

1 reference

https://pubmed.ncbi.nlm.nih.gov/17887753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and primary structure of C-1027-AG, a selective antagonist of antitumor antibiotic C-1027, from Streptomyces globisporus

1 reference

https://pubmed.ncbi.nlm.nih.gov/17887753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17887753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Halogenation of unactivated carbon centers in natural product biosynthesis: trichlorination of leucine during barbamide biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17887753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of the enediyne antitumor antibiotic C-1027

1 reference

https://pubmed.ncbi.nlm.nih.gov/17887753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some characteristics of DNA strand scission by macromolecular antitumor antibiotic C-1027 containing a novel enediyne chromophore

1 reference

https://pubmed.ncbi.nlm.nih.gov/17887753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JA072311G

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

release_xhbvyslqtvfzbc43qtl3redmky

1 reference

https://api.fatcat.wiki/v0/release/xhbvyslqtvfzbc43qtl3redmky

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

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