(Q37082467)

18 August 2017

1 reference

title

Mechanisms of disease: the hypoxic tubular hypothesis of diabetic nephropathy (English)

1 reference

18 August 2017

0 references

Dhruv K Singh

1

1 reference

18 August 2017

Peter Winocour

series ordinal

2

1 reference

18 August 2017

Ken Farrington

series ordinal

3

1 reference

18 August 2017

publication date

12 February 2008

1 reference

Nature Clinical Practice Nephrology

18 August 2017

published in

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18 August 2017

volume

4

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18 August 2017

issue

4

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18 August 2017

page(s)

216-226

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The stages in diabetic renal disease. With emphasis on the stage of incipient diabetic nephropathy

18 August 2017

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Reversible hematologic sequelae of diabetes mellitus

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The anemia of primary autonomic failure and its reversal with recombinant erythropoietin

21 January 2018

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A vitamin D analog ameliorates glomerular injury on rat glomerulonephritis

21 January 2018

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1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system

21 January 2018

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Early-glycation of apolipoprotein E: effect on its binding to LDL receptor, scavenger receptor A and heparan sulfates.

21 January 2018

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A novel protective effect of erythropoietin in the infarcted heart

21 January 2018

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Microalbuminuria as a predictor of clinical diabetic nephropathy

21 January 2018

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7 January 2021

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7 January 2021

The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury?

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7 January 2021

Heterogeneous nature of microalbuminuria in NIDDM: studies of endothelial function and renal structure

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7 January 2021

Structural-functional relationships in diabetic nephropathy

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7 January 2021

Clinical and histological correlations of decline in renal function in diabetic patients with proteinuria

1 reference

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7 January 2021

Urinary N-acetyl B glucosaminidase as an earlier marker of diabetic nephropathy and influence of low-dose perindopril/indapamide combination.

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7 January 2021

Enzymuria in non-insulin-dependent diabetic patients: signs of tubular cell dysfunction

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7 January 2021

Functional erythropoietin deficiency in patients with Type 2 diabetes and anaemia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

High glucose increases growth and collagen synthesis in cultured human tubulointerstitial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Polyol pathway mediates high glucose-induced collagen synthesis in proximal tubule

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Aldose reductase and the role of the polyol pathway in diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Sodium-hydrogen exchange and glucose transport in renal microvillus membrane vesicles from rats with diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Diabetic vascular complications

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Pathogenesis, prevention, and treatment of diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Induction of TGF-beta 1 synthesis in D-glucose primed human proximal tubular cells by IL-1 beta and TNF alpha

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Peritubular capillary loss is associated with chronic tubulointerstitial injury in human kidney: altered expression of vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

A role for uric acid in the progression of renal disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Role of oxidative stress in development of complications in diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Pathogenesis of diabetic nephropathy: a radical approach

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Polyol-pathway-dependent disturbances in renal medullary metabolism in experimental insulin-deficient diabetes mellitus in rats.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Can we model nitric oxide biotransport? A survey of mathematical models for a simple diatomic molecule with surprisingly complex biological activities

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Reduced nitric oxide concentration in the renal cortex of streptozotocin-induced diabetic rats: effects on renal oxygenation and microcirculation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Oxygen-dependent inhibition of respiration in isolated renal tubules by nitric oxide

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Intrarenal oxygen in diabetes and a possible link to diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

HIF activation by pH-dependent nucleolar sequestration of VHL.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Hypoxic induction of Ctgf is directly mediated by Hif-1.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

HIF-1: an oxygen response system with special relevance to the kidney

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

The breathing kidney.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Evidence of tubular hypoxia in the early phase in the remnant kidney model

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Hypoxia promotes fibrogenesis in human renal fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Hypokalemia induces renal injury and alterations in vasoactive mediators that favor salt sensitivity

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Advanced glycosylation endproducts on erythrocyte cell surface induce receptor-mediated phagocytosis by macrophages. A model for turnover of aging cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Hematologic alterations in diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Reversible sodium pump defect and swelling in the diabetic rat erythrocyte: effects on filterability and implications for microangiopathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

The influence of the autonomic nervous system in the control of erythropoietin secretion in the hypoxic rat

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Abnormal membrane fluidity and acetylcholinesterase activity in erythrocytes from insulin-dependent diabetic patients.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Anemia with erythropoietin deficiency occurs early in diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Unrecognized anemia in patients with diabetes: a cross-sectional survey

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Patterns of renal injury in NIDDM patients with microalbuminuria

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Erythropoietin depletion and anaemia in diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Erythropoietin response to hypoxia in patients with diabetic autonomic neuropathy and non-diabetic chronic renal failure

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Diabetes impairs endothelial progenitor cell-mediated blood vessel formation in response to hypoxia.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

High glucose blunts vascular endothelial growth factor response to hypoxia via the oxidative stress-regulated hypoxia-inducible factor/hypoxia-responsible element pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Damage of charge-dependent renal tubular reabsorption causes diabetic microproteinuria

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Relationship between markers of endothelial dysfunction, oxidant injury and tubular damage in patients with insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Rho-kinase-mediated Ca2+-independent contraction in rat embryo fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Glomerular hyperfiltration and the salt paradox in early [corrected] type 1 diabetes mellitus: a tubulo-centric view.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Volume reflex in diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Glomerular hyperfiltration in type 1 diabetes mellitus results from primary changes in proximal tubular sodium handling without changes in volume expansion

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Predisposition to hypertension and susceptibility to renal disease in insulin-dependent diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Inhibition of renal ornithine decarboxylase activity prevents kidney hypertrophy in experimental diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Potential role of active vitamin D in retarding the progression of chronic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Altered vitamin D metabolism in type II diabetic mouse glomeruli may provide protection from diabetic nephropathy.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Actions of 1,25-Dihydroxyvitamin D3 on Human Mesangial Cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

1,25-dihydroxyvitamin D3 and the synthetic vitamin D analogue, KH 1060, modulate the growth of mouse proximal tubular cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Effects of 1,25(OH)2D3 in experimental mesangial proliferative nephritis in rats.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Renal tubule albumin transport

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Role of hypoxia in the pathogenesis of renal disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Oxygen sensing and molecular adaptation to hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Oxidative stress mediates apoptotic changes induced by hyperglycemia in human tubular kidney cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

The enigma of the metabolic fate of circulating erythropoietin (Epo) in view of the pharmacokinetics of the recombinant drugs rhEpo and NESP.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Cellular trafficking and degradation of erythropoietin and novel erythropoiesis stimulating protein (NESP).

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Kinetic evaluation of nonlinear drug elimination by a disposition decomposition analysis. Application to the analysis of the nonlinear elimination kinetics of erythropoietin in adult humans.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

A comparison of nonlinear pharmacokinetics of erythropoietin in sheep and humans.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Receptor-based model accounts for phlebotomy-induced changes in erythropoietin pharmacokinetics

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Inappropriately low erythropoietin response for the degree of anemia in patients with noninsulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Anemia and diabetes in the absence of nephropathy.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

How should we manage anaemia in patients with diabetes?

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Role of cytokines in the response to erythropoietin in hemodialysis patients

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

In vitro suppression of erythropoiesis by bone marrow adherent cells from some patients with fungal infection

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Renoprotective role of the vitamin D receptor in diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Does paricalcitol reduce proteinuria in patients with chronic kidney disease?

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Erythropoietin receptor mRNA expression in human endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Effects of erythropoietin on endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Recombinant human erythropoietin (rHuEPO) increases endothelin-1 release by endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Recombinant human erythropoietin stimulates angiogenesis in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Treating anemia early in renal failure patients slows the decline of renal function: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Anemia lessens and its prevention with recombinant human erythropoietin worsens glomerular injury and hypertension in rats with reduced renal mass

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Correction of anemia with epoetin alfa in chronic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Improving the quality of reporting of randomized controlled trials. The CONSORT statement

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Normalization of hemoglobin level in patients with chronic kidney disease and anemia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

EPO's alter ego: erythropoietin has multiple actions.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Erythropoietin strikes a new cord

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Attenuation of interstitial inflammation and fibrosis by recombinant human erythropoietin in chronic cyclosporine nephropathy.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Neuroprotective properties of epoetin alfa.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Erythropoietin attenuates renal injury in experimental acute renal failure ischaemic/reperfusion model

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

EPO: renoprotection beyond anemia correction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Erythropoietin and acute renal failure

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Erythropoietin ameliorates renal dysfunction during endotoxaemia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Human, rat, and mouse kidney cells express functional erythropoietin receptors

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Co-localization of erythropoietin mRNA and ecto-5'-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Identification of the renal erythropoietin-producing cells using transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Distribution of erythropoietin producing cells in rat kidneys during hypoxic hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Erythropoietin in experimental acute renal failure

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Delayed administration of darbepoetin or erythropoietin protects against ischemic acute renal injury and failure

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Novel renoprotective actions of erythropoietin: new uses for an old hormone

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Erythropoietin protects against ischaemic acute renal injury

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failure

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEPH0757

7 January 2021

Identifiers

DOI

10.1038/NCPNEPH0757

1 reference

18 August 2017

1 reference