(Q37088939)

18 August 2017

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title

The success of the genome-wide association approach: a brief story of a long struggle (English)

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genome-wide association study

18 August 2017

main subject

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author name string

Ku Chee Seng

series ordinal

1

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18 August 2017

Chia Kee Seng

series ordinal

2

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18 August 2017

publication date

20 February 2008

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European Journal of Human Genetics

18 August 2017

published in

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18 August 2017

volume

16

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18 August 2017

issue

5

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18 August 2017

page(s)

554-564

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The future of genetic studies of complex human diseases

18 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Initial sequencing and analysis of the human genome

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Finishing the euchromatic sequence of the human genome

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Large-scale copy number polymorphism in the human genome

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Detection of large-scale variation in the human genome

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Global variation in copy number in the human genome

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Structural variation in the human genome

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Relative impact of nucleotide and copy number variation on gene expression phenotypes

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European A

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Strong association of de novo copy number mutations with autism

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Increase inGSK3β gene copy number variation in bipolar disorder

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

The International HapMap Project

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A haplotype map of the human genome

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A second generation human haplotype map of over 3.1 million SNPs

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Transferability of tag SNPs in genetic association studies in multiple populations

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A worldwide survey of haplotype variation and linkage disequilibrium in the human genome

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Tag SNPs chosen from HapMap perform well in several population isolates

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Whole-genome patterns of common DNA variation in three human populations

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genome-wide association studies: theoretical and practical concerns

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genome-wide association studies for common diseases and complex traits

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A genome-wide scalable SNP genotyping assay using microarray technology

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Whole genome genotyping technologies on the BeadArray platform

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Large-scale genotyping of complex DNA.

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Evaluating coverage of genome-wide association studies

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Power to detect risk alleles using genome-wide tag SNP panels

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

PLINK: a tool set for whole-genome association and population-based linkage analyses

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Whole-genome re-sequencing

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Complement factor H polymorphism in age-related macular degeneration

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

HTRA1 promoter polymorphism in wet age-related macular degeneration

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A common genetic variant is associated with adult and childhood obesity

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A genome-wide association study identifies novel risk loci for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genome-wide association study identifies novel breast cancer susceptibility loci

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Replicating genotype-phenotype associations

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Complement factor H variant increases the risk of age-related macular degeneration

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Complement factor H polymorphism and age-related macular degeneration

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Systematic review and meta-analysis of the association between complement factor H Y402H polymorphisms and age-related macular degeneration

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Comment on "A common genetic variant is associated with adult and childhood obesity"

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Comment on "A common genetic variant is associated with adult and childhood obesity"

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

IL23R Arg381Gln is associated with childhood onset inflammatory bowel disease in Scotland

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Confirmation of the role of ATG16l1 as a Crohnʼs disease susceptibility gene

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A Nonsynonymous SNP in ATG16L1 Predisposes to Ileal Crohn’s Disease and Is Independent of CARD15 and IBD5

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A common coding variant in CASP8 is associated with breast cancer risk

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A common variant associated with prostate cancer in European and African populations

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Multiple regions within 8q24 independently affect risk for prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A common allele on chromosome 9 associated with coronary heart disease

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A common variant on chromosome 9p21 affects the risk of myocardial infarction

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

High-resolution whole-genome association study of Parkinson disease.

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Conflicting results regarding the semaphorin gene (SEMA5A) and the risk for Parkinson disease

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

No evidence for association with Parkinson disease for 13 single-nucleotide polymorphisms identified by whole-genome association screening.

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A case-control association study of the 12 single-nucleotide polymorphisms implicated in Parkinson disease by a recent genome scan

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Power analysis for genome-wide association studies

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

New models of collaboration in genome-wide association studies: the Genetic Association Information Network

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Ranks of genuine associations in whole-genome scans.

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Matrix-assisted laser desorption/ionisation, time-of-flight mass spectrometry in genomics research

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

The effects of human population structure on large genetic association studies

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Principal components analysis corrects for stratification in genome-wide association studies

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

The ENCODE (ENCyclopedia Of DNA Elements) Project

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Problems with Genome-Wide Association Studies

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A genetic risk factor for periodic limb movements in sleep

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genomewide association analysis of coronary artery disease

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Risk alleles for multiple sclerosis identified by a genomewide study

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A whole-genome association study of major determinants for host control of HIV-1

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Variants conferring risk of atrial fibrillation on chromosome 4q25.

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Whole-genome analysis of sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Two independent alleles at 6q23 associated with risk of rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1038%2FEJHG.2008.12

7 January 2021

Identifiers

DOI

10.1038/EJHG.2008.12

1 reference

18 August 2017

1 reference