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Protein metamorphosis: the two-state behavior of Mad2.
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Europe PubMed Central
PMCID
2644451
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18 August 2017
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title
Protein metamorphosis: the two-state behavior of Mad2.
(English)
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PMCID
2644451
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18 August 2017
author name string
Xuelian Luo
series ordinal
1
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Europe PubMed Central
PMCID
2644451
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18 August 2017
Hongtao Yu
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2
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PMCID
2644451
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18 August 2017
publication date
1 November 2008
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PMCID
2644451
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18 August 2017
published in
Structure
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PMCID
2644451
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18 August 2017
volume
16
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PMCID
2644451
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18 August 2017
page(s)
1616-1625
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PMCID
2644451
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18 August 2017
issue
11
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Europe PubMed Central
PMCID
2644451
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18 August 2017
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Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer
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p31comet blocks Mad2 activation through structural mimicry
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The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint
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Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis
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14 September 2017
The anaphase promoting complex/cyclosome: a machine designed to destroy
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14 September 2017
Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model
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14 September 2017
Determinants of conformational dimerization of Mad2 and its inhibition by p31comet
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14 September 2017
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14 September 2017
The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint
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14 September 2017
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint
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14 September 2017
Timing and checkpoints in the regulation of mitotic progression
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14 September 2017
Emerging principles of conformation-based prion inheritance
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14 September 2017
Spindle checkpoint protein dynamics at kinetochores in living cells.
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14 September 2017
Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing
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The spindle checkpoint, aneuploidy, and cancer
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14 September 2017
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14 September 2017
The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint
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14 September 2017
Identification of a MAD2-binding protein, CMT2, and its role in mitosis
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Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells
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14 September 2017
BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1.
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Segregating sister genomes: the molecular biology of chromosome separation
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Inducing precocious anaphase in cultured mammalian cells
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14 September 2017
Spindle checkpoint requires Mad1-bound and Mad1-free Mad2.
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14 September 2017
Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint
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14 September 2017
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20
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14 September 2017
Serpins and other covalent protease inhibitors
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14 September 2017
Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint
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14 September 2017
MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
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14 September 2017
Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase
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14 September 2017
Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20
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14 September 2017
Prions
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14 September 2017
Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
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14 September 2017
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
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14 September 2017
Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events
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14 September 2017
Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint
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14 September 2017
Budding yeast Cdc20: a target of the spindle checkpoint.
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14 September 2017
Mice devoid of PrP are resistant to scrapie
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14 September 2017
Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast
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14 September 2017
Principles that govern the folding of protein chains
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14 September 2017
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation
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27 June 2018
Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.
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27 June 2018
Structural basis of latency in plasminogen activator inhibitor-1
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27 June 2018
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
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27 June 2018
Aneuploidy acts both oncogenically and as a tumor suppressor
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3 September 2018
In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamics.
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3 September 2018
The Mad2 spindle checkpoint protein has two distinct natively folded states.
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3 September 2018
Using relaxation dispersion NMR spectroscopy to determine structures of excited, invisible protein states
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12 December 2020
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Identifiers
DOI
10.1016/J.STR.2008.10.002
1 reference
stated in
Europe PubMed Central
PMCID
2644451
retrieved
18 August 2017
PMCID
2644451
1 reference
stated in
Europe PubMed Central
PMCID
2644451
retrieved
18 August 2017
PubMed ID
19000814
1 reference
stated in
Europe PubMed Central
PMCID
2644451
retrieved
18 August 2017
ResearchGate publication ID
23465317
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