(Q37103616)

18 August 2017

1 reference

title

Cell-division inhibitors: new insights for future antibiotics (English)

1 reference

18 August 2017

0 references

2

1 reference

18 August 2017

Rowena L Lock

1

1 reference

18 August 2017

publication date

1 April 2008

1 reference

Nature Reviews Drug Discovery

18 August 2017

published in

1 reference

18 August 2017

volume

7

1 reference

18 August 2017

issue

4

1 reference

18 August 2017

page(s)

324-338

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd2510

18 August 2017

exact match

0 references

cites work

Antibiotics: a shot in the arm

1 reference

Retapamulin: a semisynthetic pleuromutilin compound for topical treatment of skin infections in adults and children

31 March 2020

1 reference

The price of innovation: new estimates of drug development costs

31 March 2020

1 reference

Drugs for bad bugs: confronting the challenges of antibacterial discovery

31 March 2020

1 reference

Antimicrobials: new solutions badly needed

31 March 2020

1 reference

Where will new antibiotics come from?

31 March 2020

1 reference

Harnessing the power of the genome in the search for new antibiotics

31 March 2020

1 reference

Dynamic proteins and a cytoskeleton in bacteria.

31 March 2020

1 reference

Functional genomics in antibacterial drug discovery

31 March 2020

1 reference

31 March 2020

Cytokinesis in bacteria

1 reference

Diverse paths to midcell: assembly of the bacterial cell division machinery

31 March 2020

1 reference

Bacterial cell division: the mechanism and its precison

31 March 2020

1 reference

Septum enlightenment: assembly of bacterial division proteins

31 March 2020

1 reference

Cell division in Bacillus subtilis: FtsZ and FtsA association is Z-ring independent, and FtsA is required for efficient midcell Z-Ring assembly

31 March 2020

1 reference

Dispersed mode of Staphylococcus aureus cell wall synthesis in the absence of the division machinery

31 March 2020

1 reference

Assembly of cell division proteins at the E. coli cell center

31 March 2020

1 reference

FtsQ, FtsL and FtsI require FtsK, but not FtsN, for co-localization with FtsZ during Escherichia coli cell division

31 March 2020

1 reference

Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly.

31 March 2020

1 reference

Crystal structure of the bacterial cell-division protein FtsZ

31 March 2020

1 reference

Structure of the alpha beta tubulin dimer by electron crystallography

31 March 2020

1 reference

An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins

31 March 2020

1 reference

Crystal structure of the cell division protein FtsA from Thermotoga maritima

31 March 2020

1 reference

Direct binding of FtsZ to ZipA, an essential component of the septal ring structure that mediates cell division in E. coli

31 March 2020

1 reference

The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography

31 March 2020

1 reference

Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction

31 March 2020

1 reference

Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction

31 March 2020

1 reference

Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction

31 March 2020

1 reference

Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design

31 March 2020

1 reference

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

31 March 2020

1 reference

Genetic analysis of the Escherichia coli FtsZ.ZipA interaction in the yeast two-hybrid system. Characterization of FtsZ residues essential for the interactions with ZipA and with FtsA

31 March 2020

1 reference

31 March 2020

1 reference

Escherichia coli cell-division gene ftsZ encodes a novel GTP-binding protein

31 March 2020

1 reference

The essential bacterial cell-division protein FtsZ is a GTPase

31 March 2020

1 reference

Escherichia coli cell division protein FtsZ is a guanine nucleotide binding protein

31 March 2020

1 reference

Cell division in cocci: localization and properties of the Streptococcus pneumoniae FtsA protein

31 March 2020

1 reference

Role of the carboxy terminus of Escherichia coli FtsA in self-interaction and cell division

31 March 2020

1 reference

Discovering high-affinity ligands for proteins: SAR by NMR

31 March 2020

1 reference

Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening

31 March 2020

1 reference

Exploring protein-protein interactions with phage display

31 March 2020

1 reference

Inhibition of protein-protein association by small molecules: approaches and progress

31 March 2020

1 reference

Convergent solutions to binding at a protein-protein interface

31 March 2020

1 reference

Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

31 March 2020

1 reference

Rational drug design via intrinsically disordered protein

31 March 2020

1 reference

Coupled folding and binding with alpha-helix-forming molecular recognition elements

31 March 2020

1 reference

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

31 March 2020

1 reference

31 March 2020

FtsZ and cell division.

1 reference

Assembly Dynamics of the Bacterial Cell Division Protein FtsZ: Poised at the Edge of Stability

31 March 2020

1 reference

2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ.

31 March 2020

1 reference

A new 2-carbamoyl pteridine that inhibits mycobacterial FtsZ.

31 March 2020

1 reference

Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics

31 March 2020

1 reference

Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality

31 March 2020

1 reference

GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin

31 March 2020

1 reference

Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay

31 March 2020

1 reference

Identification of Pseudomonas aeruginosa FtsZ peptide inhibitors as a tool for development of novel antimicrobials

31 March 2020

1 reference

Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZ assembly and bundling

31 March 2020

1 reference

Parallel solid synthesis of inhibitors of the essential cell division FtsZ enzyme as a new potential class of antibacterials.

31 March 2020

1 reference

The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?

31 March 2020

1 reference

FtsZ: a novel target for tuberculosis drug discovery

31 March 2020

1 reference

Z ring as executor of bacterial cell division

31 March 2020

1 reference

FtsZ and the division of prokaryotic cells and organelles

31 March 2020

1 reference

Dynamic Filaments of the Bacterial Cytoskeleton

31 March 2020

1 reference

Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers

31 March 2020

1 reference

Ca2+-mediated GTP-dependent dynamic assembly of bacterial cell division protein FtsZ into asters and polymer networks in vitro

31 March 2020

1 reference

Dynamic assembly of FtsZ regulated by GTP hydrolysis

31 March 2020

1 reference

Tubulin-like protofilaments in Ca2+-induced FtsZ sheets

31 March 2020

1 reference

Slow polymerization of Mycobacterium tuberculosis FtsZ

31 March 2020

1 reference

Polymerization of Ftsz, a bacterial homolog of tubulin. is assembly cooperative?

31 March 2020

1 reference

Assembly of archaeal cell division protein FtsZ and a GTPase-inactive mutant into double-stranded filaments.

31 March 2020

1 reference

Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents

31 March 2020

1 reference

Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.

31 March 2020

1 reference

Chromosome partitioning in Escherichia coli: novel mutants producing anucleate cells

31 March 2020

1 reference

A 4-aminofurazan derivative-A189-inhibits assembly of bacterial cell division protein FtsZ in vitro and in vivo.

31 March 2020

1 reference

Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle

31 March 2020

1 reference

Improving the targeting of tubulin-binding agents: lessons from drug resistance studies.

31 March 2020

1 reference

Rapid assembly dynamics of the Escherichia coli FtsZ-ring demonstrated by fluorescence recovery after photobleaching

31 March 2020

1 reference

Identification and characterization of a negative regulator of FtsZ ring formation in Bacillus subtilis

31 March 2020

1 reference

A widely conserved bacterial cell division protein that promotes assembly of the tubulin-like protein FtsZ.

31 March 2020

1 reference

A new FtsZ-interacting protein, YlmF, complements the activity of FtsA during progression of cell division in Bacillus subtilis

31 March 2020

1 reference

Impaired cell division and sporulation of a Bacillus subtilis strain with the ftsA gene deleted

31 March 2020

1 reference

Peptide inhibitors of the essential cell division protein FtsA.

31 March 2020

1 reference

Identification of a region of FtsA required for interaction with FtsZ.

31 March 2020

1 reference

Tethering the Z ring to the membrane through a conserved membrane targeting sequence in FtsA.

31 March 2020

1 reference

The proper ratio of FtsZ to FtsA is required for cell division to occur in Escherichia coli

31 March 2020

1 reference

A conserved residue at the extreme C-terminus of FtsZ is critical for the FtsA-FtsZ interaction in Staphylococcus aureus

31 March 2020

1 reference

RNase E maintenance of proper FtsZ/FtsA ratio required for nonfilamentous growth of Escherichia coli cells but not for colony-forming ability

31 March 2020

1 reference

Analysis of the interaction of FtsZ with itself, GTP, and FtsA.

31 March 2020

1 reference

Dominant C-terminal deletions of FtsZ that affect its ability to localize in Caulobacter and its interaction with FtsA

31 March 2020

1 reference

ZipA is required for recruitment of FtsK, FtsQ, FtsL, and FtsN to the septal ring in Escherichia coli

31 March 2020

1 reference

Z-ring-independent interaction between a subdomain of FtsA and late septation proteins as revealed by a polar recruitment assay

31 March 2020

1 reference

Role of two essential domains of Escherichia coli FtsA in localization and progression of the division ring

31 March 2020

1 reference

Mutants, suppressors, and wrinkled colonies: mutant alleles of the cell division gene ftsQ point to functional domains in FtsQ and a role for domain 1C of FtsA in divisome assembly

31 March 2020

1 reference

Premature targeting of a cell division protein to midcell allows dissection of divisome assembly in Escherichia coli.

31 March 2020

1 reference

Unique and overlapping roles for ZipA and FtsA in septal ring assembly in Escherichia coli

31 March 2020

1 reference

ZipA-induced bundling of FtsZ polymers mediated by an interaction between C-terminal domains

31 March 2020

1 reference

ZipA is a MAP-Tau homolog and is essential for structural integrity of the cytokinetic FtsZ ring during bacterial cell division

31 March 2020

1 reference

Structural evidence that the P/Q domain of ZipA is an unstructured, flexible tether between the membrane and the C-terminal FtsZ-binding domain

31 March 2020

1 reference

Recruitment of ZipA to the division site by interaction with FtsZ

31 March 2020

1 reference

Solution structure of ZipA, a crucial component of Escherichia coli cell division

31 March 2020

1 reference

A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction

31 March 2020

1 reference

Detailed microscopic study of the full zipA:FtsZ interface.

31 March 2020

1 reference

The crystal structure of ZapA and its modulation of FtsZ polymerisation

31 March 2020

1 reference

A predicted ABC transporter, FtsEX, is needed for cell division in Escherichia coli

31 March 2020

1 reference

Interaction between cell division proteins FtsE and FtsZ.

31 March 2020

1 reference

Role of FtsEX in cell division of Escherichia coli: viability of ftsEX mutants is dependent on functional SufI or high osmotic strength

31 March 2020

1 reference

Two types of FtsZ proteins in mitochondria and red-lineage chloroplasts: the duplication of FtsZ is implicated in endosymbiosis

31 March 2020

1 reference

SepF, a novel FtsZ-interacting protein required for a late step in cell division

31 March 2020

1 reference

Identification of cyanobacterial cell division genes by comparative and mutational analyses.

31 March 2020

1 reference

Maturation of the Escherichia coli divisome occurs in two steps.

31 March 2020

1 reference

Crystallizing new approaches for antimicrobial drug discovery

31 March 2020

1 reference

Circles: the replication-recombination-chromosome segregation connection

31 March 2020

1 reference

Bacillus subtilis spoIIIE protein required for DNA segregation during asymmetric cell division

31 March 2020

1 reference

Bacterial cell wall synthesis: new insights from localization studies

31 March 2020

1 reference

A complex four-gene operon containing essential cell division gene pbpB in Bacillus subtilis

31 March 2020

1 reference

Cloning, characterization, and inactivation of the gene pbpC, encoding penicillin-binding protein 3 of Staphylococcus aureus

31 March 2020

1 reference

Role of PBP1 in cell division of Staphylococcus aureus

31 March 2020

1 reference

Growth and division of Streptococcus pneumoniae: localization of the high molecular weight penicillin‐binding proteins during the cell cycle

31 March 2020

1 reference

ftsW is an essential cell-division gene in Escherichia coli

31 March 2020

1 reference

Control of cell shape and elongation by the rodA gene in Bacillus subtilis

31 March 2020

1 reference

The Escherichia coli cell division protein FtsW is required to recruit its cognate transpeptidase, FtsI (PBP3), to the division site.

31 March 2020

1 reference

Interaction between FtsW and penicillin-binding protein 3 (PBP3) directs PBP3 to mid-cell, controls cell septation and mediates the formation of a trimeric complex involving FtsZ, FtsW and PBP3 in mycobacteria.

31 March 2020

1 reference

Interaction between FtsZ and FtsW of Mycobacterium tuberculosis

31 March 2020

1 reference

Overproduction and identification of the ftsQ gene product, an essential cell division protein in Escherichia coli K-12

31 March 2020

1 reference

YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site

31 March 2020

1 reference

Use of a two-hybrid assay to study the assembly of a complex multicomponent protein machinery: bacterial septosome differentiation.

31 March 2020

1 reference

Interaction network among Escherichia coli membrane proteins involved in cell division as revealed by bacterial two-hybrid analysis

31 March 2020

1 reference

In vitro reconstitution of a trimeric complex of DivIB, DivIC and FtsL, and their transient co-localization at the division site in Streptococcus pneumoniae

31 March 2020

1 reference

Multiple interactions between the transmembrane division proteins of Bacillus subtilis and the role of FtsL instability in divisome assembly

31 March 2020

1 reference

Characterization of a cell division gene from Bacillus subtilis that is required for vegetative and sporulation septum formation

31 March 2020

1 reference

Nucleotide sequence and insertional inactivation of a Bacillus subtilis gene that affects cell division, sporulation, and temperature sensitivity

31 March 2020

1 reference

Septal localization of the membrane-bound division proteins of Bacillus subtilis DivIB and DivIC is codependent only at high temperatures and requires FtsZ.

31 March 2020

1 reference

The Bacillus subtilis cell division proteins FtsL and DivIC are intrinsically unstable and do not interact with one another in the absence of other septasomal components.

31 March 2020

1 reference

Three functional subdomains of the Escherichia coli FtsQ protein are involved in its interaction with the other division proteins

31 March 2020

1 reference

POTRA: a conserved domain in the FtsQ family and a class of beta-barrel outer membrane proteins

31 March 2020

1 reference

Domain architecture and structure of the bacterial cell division protein DivIB

31 March 2020

1 reference

Requirement for the cell division protein DivIB in polar cell division and engulfment during sporulation in Bacillus subtilis

31 March 2020

1 reference

Analysis of the essential cell division gene ftsL of Bacillus subtilis by mutagenesis and heterologous complementation

31 March 2020

1 reference

Intrinsic instability of the essential cell division protein FtsL of Bacillus subtilis and a role for DivIB protein in FtsL turnover

31 March 2020

1 reference

7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia

31 March 2020

1 reference

Bioassay-guided purification and identification of antimicrobial components in Chinese green tea extract.

31 March 2020

1 reference

Screening for peptide drugs from the natural repertoire of biodiverse protein folds

31 March 2020

1 reference

A practical view of 'druggability'.

31 March 2020

1 reference

ftsZ is an essential cell division gene in Escherichia coli

31 March 2020

1 reference

A physical and functional interaction between Escherichia coli FtsK and topoisomerase IV.

31 March 2020

1 reference

Double-Stranded DNA Translocation: Structure and Mechanism of Hexameric FtsK

31 March 2020

1 reference

Properties of the Penicillin-Binding Proteins of Escherichia coli K12

31 March 2020

1 reference

Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations

31 March 2020

1 reference

Solution structure and domain architecture of the divisome protein FtsN.

31 March 2020

1 reference

The Escherichia coli amidase AmiC is a periplasmic septal ring component exported via the twin-arginine transport pathway

31 March 2020

1 reference

Involvement of N-acetylmuramyl-L-alanine amidases in cell separation and antibiotic-induced autolysis of Escherichia coli

31 March 2020

1 reference

Essential Bacillus subtilis genes

31 March 2020

1 reference

Screening for synthetic lethal mutants in Escherichia coli and identification of EnvC (YibP) as a periplasmic septal ring factor with murein hydrolase activity.

31 March 2020

1 reference

The Microbial Rosetta Stone Database: a compilation of global and emerging infectious microorganisms and bioterrorist threat agents

31 March 2020

1 reference

Identification of the ftsA gene product

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Genetic and functional analyses of the conserved C-terminal core domain of Escherichia coli FtsZ

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Recruitment of ZipA to the septal ring of Escherichia coli is dependent on FtsZ and independent of FtsA.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD2510

1 reference

18 August 2017

1 reference