(Q37121130)

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Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

scientific article published on December 2008

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scholarly article

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17 January 2020

Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors (English)

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17 January 2020

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17 January 2020

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17 January 2020

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17 January 2020

author name string

Ruth Plummer

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17 January 2020

Christopher Jones

2

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17 January 2020

Mark Middleton

3

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17 January 2020

Richard Wilson

4

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17 January 2020

Jeffrey Evans

5

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17 January 2020

Anna Olsen

6

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17 January 2020

Peter McHugh

9

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17 January 2020

David Newell

10

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17 January 2020

Patrick Johnson

12

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17 January 2020

Heidi Steinfeldt

13

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17 January 2020

Raz Dewji

14

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17 January 2020

Diane Wang

15

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17 January 2020

Lesley Robson

16

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17 January 2020

Hilary Calvert

17

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17 January 2020

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publication date

1 December 2008

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17 January 2020

Clinical Cancer Research

1 reference

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17 January 2020

14

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17 January 2020

23

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17 January 2020

7917-7923

1 reference

Europe PubMed Central

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17 January 2020

A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma

1 reference

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14 September 2017

Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure.

1 reference

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The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer

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14 September 2017

Poly(ADP-ribose)polymerase inhibition - where now?

1 reference

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Overview of tumor cell chemoresistance mechanisms

1 reference

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14 September 2017

Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.

1 reference

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14 September 2017

PARP inhibitors for cancer therapy.

1 reference

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14 September 2017

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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14 September 2017

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

1 reference

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14 September 2017

Crosslinks and crosstalk: human cancer syndromes and DNA repair defects

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14 September 2017

Repair and genetic consequences of endogenous DNA base damage in mammalian cells

1 reference

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14 September 2017

Poly(ADP-ribosyl)ation inhibitors: promising drug candidates for a wide variety of pathophysiologic conditions

1 reference

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14 September 2017

DNA repair and tumorigenesis: lessons from hereditary cancer syndromes

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14 September 2017

Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine

1 reference

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14 September 2017

Temozolomide: a novel oral alkylating agent

1 reference

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14 September 2017

Genome maintenance mechanisms for preventing cancer

1 reference

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14 September 2017

Expression of poly(ADP-ribose) polymerase and distribution of poly(ADP-ribosyl)ation in glioblastoma and in a glioma multicellular tumour spheroid model

1 reference

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14 September 2017

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

1 reference

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14 September 2017

Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652879

14 September 2017

Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652879

14 September 2017

Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652879

14 September 2017

Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652879

14 September 2017

Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652879

14 September 2017

RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer

1 reference

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14 September 2017

Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652879

14 September 2017

Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652879

14 September 2017

Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652879

14 September 2017

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2652879

14 September 2017

O6-alkylguanine-DNA alkyltransferase depletion and regeneration in human peripheral lymphocytes following dacarbazine and fotemustine

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27 June 2018

RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer.

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3 September 2018

Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma

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3 September 2018

A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats

1 reference

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3 September 2018

Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma

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An analysis of DNA repair as a determinant of survival in patients with non-small-cell lung cancer.

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DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

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Involvement of the mismatch repair system in temozolomide-induced apoptosis

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3 September 2018

Randomized Trial of the Combination of Lomeguatrib and Temozolomide Compared With Temozolomide Alone in Chemotherapy Naive Patients With Metastatic Cutaneous Melanoma

1 reference

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4 December 2018

Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region

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4 December 2018

Comparison between the DNA precipitation and alkali unwinding assays for detecting DNA strand breaks and cross-links

1 reference

https://pubmed.ncbi.nlm.nih.gov/19047122

12 December 2020

based on heuristic

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PARP-1 inhibition to treat cancer, ischemia, inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19047122

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological inhibition of poly(ADP-ribose) polymerase in cardiovascular disorders: future directions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19047122

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genentech raises stakes on PARP inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19047122

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19047122

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1078-0432.CCR-08-1223

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19047122%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19047122%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19047122%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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