(Q37139420)

18 August 2017

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title

The neuregulin family of genes and their multiple splice variants in breast cancer (English)

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18 August 2017

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Nandini V L Hayes

1

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PubMed ID

18415007

18 August 2017

William J Gullick

series ordinal

2

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18 August 2017

15 April 2008

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Journal of Mammary Gland Biology and Neoplasia

18 August 2017

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18 August 2017

13

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18 August 2017

205-214

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18 August 2017

2

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https://scigraph.springernature.com/pub.10.1007/s10911-008-9078-4

18 August 2017

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A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4

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https://api.crossref.org/works/10.1007%2FS10911-008-9078-4

Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10911-008-9078-4

Characterization of the cell membrane-associated products of the Neuregulin 4 gene.

21 January 2018

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12 December 2020

Neuregulin-2 is synthesized by motor neurons and terminal Schwann cells and activates acetylcholine receptor transcription in muscle cells expressing ErbB4.

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12 December 2020

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

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12 December 2020

A Recurrent Chromosome Breakpoint in Breast Cancer at theNRG1/Neuregulin 1/HeregulinGene

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12 December 2020

Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses

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12 December 2020

NRG-3 in human breast cancers: activation of multiple erbB family proteins.

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12 December 2020

Neuregulins 1-4 are expressed in the cytoplasm or nuclei of ductal carcinoma (in situ) of the human breast

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12 December 2020

Neuroglycan C, a novel member of the neuregulin family

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12 December 2020

Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

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12 December 2020

Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology

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12 December 2020

COOH-terminal extended recombinant amphiregulin with bioactivity comparable with naturally derived growth factor

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12 December 2020

Pathogenesis of Paget's disease: epidermal heregulin-alpha, motility factor, and the HER receptor family.

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12 December 2020

Mitogen-activated protein kinase-dependent and -independent routes control shedding of transmembrane growth factors through multiple secretases.

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12 December 2020

The ErbB signaling network: receptor heterodimerization in development and cancer

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12 December 2020

High-resolution analysis of chromosome rearrangements on 8p in breast, colon and pancreatic cancer reveals a complex pattern of loss, gain and translocation

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12 December 2020

Co-expression of neuregulins 1, 2, 3 and 4 in human breast cancer.

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12 December 2020

A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene

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12 December 2020

Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification

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12 December 2020

Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase

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12 December 2020

Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail

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12 December 2020

PI3 kinase activation and response to Trastuzumab Therapy: what's neu with herceptin resistance?

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12 December 2020

Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells.

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12 December 2020

Intra- and extracellular signaling by endothelial neuregulin-1

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12 December 2020

Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival

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12 December 2020

Generation and characterization of neuregulin-2-deficient mice.

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12 December 2020

Dynamic expression of Erbb pathway members during early mammary gland morphogenesis.

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12 December 2020

ADAM-17 predicts adverse outcome in patients with breast cancer

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12 December 2020

Targeting TACE-dependent EGFR ligand shedding in breast cancer

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12 December 2020

Back signaling by the Nrg-1 intracellular domain

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12 December 2020

Neuregulins: functions, forms, and signaling strategies

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12 December 2020

Meltrin beta (ADAM19) mediates ectodomain shedding of Neuregulin beta1 in the Golgi apparatus: fluorescence correlation spectroscopic observation of the dynamics of ectodomain shedding in living cells

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12 December 2020

Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer

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12 December 2020

Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis

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12 December 2020

Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network

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12 December 2020

Untangling the ErbB signalling network

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12 December 2020

Tomoregulin-2 is found extensively in plaques in Alzheimer's disease brain.

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12 December 2020

The immunoglobulin-like domain is involved in interaction of Neuregulin1 with ErbB.

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12 December 2020

Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity

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12 December 2020

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

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12 December 2020

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

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12 December 2020

Mapping nucleolar and spliceosome localization sequences of neuregulin1-beta3.

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12 December 2020

Targeting HER proteins in cancer therapy and the role of the non-target HER3.

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12 December 2020

NTAKalpha and beta isoforms stimulate breast tumor cell growth by means of different receptor combinations

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12 December 2020

A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells

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12 December 2020

Multiple novel transcription initiation sites for NRG1

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12 December 2020

Neuregulin 1-alpha expression in locally advanced breast cancer

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12 December 2020

Neuregulin-2 is developmentally regulated and targeted to dendrites of central neurons.

1 reference

12 December 2020

Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3

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12 December 2020

Heregulins implicated in cellular functions other than receptor activation

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12 December 2020

Neuregulins: versatile growth and differentiation factors in nervous system development and human disease

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12 December 2020

Ligands for ErbB-family receptors encoded by a neuregulin-like gene

1 reference

12 December 2020

Biosynthetic processing of neu differentiation factor. Glycosylation trafficking, and regulated cleavage from the cell surface

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12 December 2020

NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice

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12 December 2020

Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA

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12 December 2020

Interaction of epidermal growth factor with its receptor

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12 December 2020

Gamma-heregulin: a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175.

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12 December 2020

Multiple essential functions of neuregulin in development

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12 December 2020

Binding specificities and affinities of egf domains for ErbB receptors

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12 December 2020

Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4

1 reference

12 December 2020

ErbB-dependent signaling as a determinant of trastuzumab resistance

1 reference

12 December 2020

Neuregulin isoforms exhibit distinct patterns of ErbB family receptor activation.

1 reference

12 December 2020

The human neuregulin-2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q

1 reference

12 December 2020

Neuregulin expression modulates clinical response to trastuzumab in patients with metastatic breast cancer

1 reference

12 December 2020

Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

1 reference

12 December 2020

10.1007/S10911-008-9078-4

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18415007