(Q37140657)

18 August 2017

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title

Manufacturing and characterizing AAV-based vectors for use in clinical studies (English)

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18 August 2017

J F Wright

1

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18 August 2017

17 April 2008

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18 August 2017

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18 August 2017

15

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18 August 2017

11

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18 August 2017

840-848

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https://scigraph.springernature.com/pub.10.1038/gt.2008.65

18 August 2017

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Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses

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Quantification of adeno-associated virus particles and empty capsids by optical density measurement

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Infectious titer assay for adeno-associated virus vectors with sensitivity sufficient to detect single infectious events

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Purification of recombinant adeno-associated virus vectors by column chromatography and its performance in vivo

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Binding of adeno-associated virus type 5 to 2,3-linked sialic acid is required for gene transfer

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Scalable purification of adeno-associated virus type 2, 4, or 5 using ion-exchange chromatography

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Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

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Separation of adeno-associated virus type 2 empty particles from genome containing vectors by anion-exchange column chromatography

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Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer

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Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions

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7 January 2021

Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV type 2.

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Factors affecting the efficiency of CD8+ T cell cross-priming with exogenous antigens

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7 January 2021

Identifiers

DOI

10.1038/GT.2008.65

1 reference

18 August 2017

1 reference

PubMed ID

18418418