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gH/gL supercomplexes at early stages of herpesvirus entry
scientific article published on 02 February 2016
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PMC publication ID
4970976
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26849495%20AND%20SRC:MED&resulttype=core&format=json
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7 March 2020
review article
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title
gH/gL supercomplexes at early stages of herpesvirus entry
(English)
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PMC publication ID
4970976
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26849495%20AND%20SRC:MED&resulttype=core&format=json
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7 March 2020
author
Ekaterina Heldwein
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1
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4970976
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26849495%20AND%20SRC:MED&resulttype=core&format=json
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7 March 2020
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Ekaterina E Heldwein
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1
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4970976
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18 August 2017
publication date
2 February 2016
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PMC publication ID
4970976
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7 March 2020
published in
Current opinion in virology
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Europe PubMed Central
PMC publication ID
4970976
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26849495%20AND%20SRC:MED&resulttype=core&format=json
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7 March 2020
volume
18
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4970976
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7 March 2020
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1-8
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PMC publication ID
4970976
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26849495%20AND%20SRC:MED&resulttype=core&format=json
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7 March 2020
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Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies
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PubMed Central
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Human Cytomegalovirus gH/gL/gO Promotes the Fusion Step of Entry into All Cell Types, whereas gH/gL/UL128-131 Broadens Virus Tropism through a Distinct Mechanism
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Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes
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αvβ6- and αvβ8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion
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Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine
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Comparative analysis of gO isoforms reveals that strains of human cytomegalovirus differ in the ratio of gH/gL/gO and gH/gL/UL128-131 in the virion envelope
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The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion
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Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines
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6 September 2017
Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry
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6 September 2017
HCMV gB shares structural and functional properties with gB proteins from other herpesviruses.
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The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma–associated herpesvirus
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Antibodies against the gH/gL/UL128/UL130/UL131 complex comprise the majority of the anti-cytomegalovirus (anti-CMV) neutralizing antibody response in CMV hyperimmune globulin
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6 September 2017
Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1
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6 September 2017
Fusion of Epstein-Barr virus with epithelial cells can be triggered by αvβ5 in addition to αvβ6 and αvβ8, and integrin binding triggers a conformational change in glycoproteins gHgL.
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PubMed Central
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6 September 2017
Human cytomegalovirus glycoprotein gO complexes with gH/gL, promoting interference with viral entry into human fibroblasts but not entry into epithelial cells
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6 September 2017
Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex
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6 September 2017
Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody
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6 September 2017
Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL
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6 September 2017
Bimolecular complementation defines functional regions of Herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion
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6 September 2017
A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells
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Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8.
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6 September 2017
Structure of Epstein-Barr Virus Glycoprotein 42 Suggests a Mechanism for Triggering Receptor-Activated Virus Entry
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6 September 2017
Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B
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6 September 2017
Human cytomegalovirus glycoproteins gB and gH/gL mediate epithelial cell-cell fusion when expressed either in cis or in trans
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PubMed Central
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6 September 2017
The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines
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6 September 2017
HCMV gH/gL/UL128-131 interferes with virus entry into epithelial cells: evidence for cell type-specific receptors
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6 September 2017
Native 3D intermediates of membrane fusion in herpes simplex virus 1 entry
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6 September 2017
Entry of herpesviruses into mammalian cells
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PubMed Central
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6 September 2017
Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins
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6 September 2017
Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion.
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6 September 2017
Mutational evidence of internal fusion loops in herpes simplex virus glycoprotein B
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6 September 2017
Crystal structure of glycoprotein B from herpes simplex virus 1.
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6 September 2017
Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4970976
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6 September 2017
Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4970976
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6 September 2017
Mutational analyses of Epstein-Barr virus glycoprotein 42 reveal functional domains not involved in receptor binding but required for membrane fusion
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4970976
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6 September 2017
Herpes simplex virus: receptors and ligands for cell entry
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4970976
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6 September 2017
Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4970976
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6 September 2017
Herpes simplex virus glycoprotein D bound to the human receptor HveA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4970976
retrieved
6 September 2017
Epstein-Barr virus uses different complexes of glycoproteins gH and gL to infect B lymphocytes and epithelial cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4970976
retrieved
6 September 2017
Epstein-Barr virus uses HLA class II as a cofactor for infection of B lymphocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4970976
retrieved
6 September 2017
Cascade of events governing cell-cell fusion induced by herpes simplex virus glycoproteins gD, gH/gL, and gB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4970976
retrieved
14 September 2017
Viral Entry.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4970976
retrieved
3 September 2018
Soluble 3-O-sulfated heparan sulfate can trigger herpes simplex virus type 1 entry into resistant Chinese hamster ovary (CHO-K1) cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4970976
retrieved
3 September 2018
Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4970976
retrieved
3 September 2018
Identifiers
DOI
10.1016/J.COVIRO.2016.01.010
1 reference
stated in
Europe PubMed Central
PMC publication ID
4970976
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26849495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 March 2020
PMC publication ID
4970976
1 reference
stated in
Europe PubMed Central
PMC publication ID
4970976
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26849495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 March 2020
PubMed publication ID
26849495
1 reference
stated in
Europe PubMed Central
PMC publication ID
4970976
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26849495%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 March 2020
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