(Q37183447)

18 August 2017

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title

Molecular genetics of hereditary renal cancer: new genes and diagnostic and therapeutic opportunities (English)

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18 August 2017

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Donna E Hansel

1

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18 August 2017

Brian I Rini

series ordinal

2

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18 August 2017

publication date

1 June 2008

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Expert Review of Anticancer Therapy

18 August 2017

published in

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18 August 2017

volume

8

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18 August 2017

issue

6

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18 August 2017

page(s)

895-905

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Mutation and cancer: statistical study of retinoblastoma

18 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

VHL inactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatment

21 January 2018

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Identification of the von Hippel-Lindau disease tumor suppressor gene

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.8.6.895

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

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The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

21 January 2018

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A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

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Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Proline hydroxylation and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Vascular endothelial growth factor signaling pathways: therapeutic perspective

21 January 2018

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Predicting benefit from anti-angiogenic agents in malignancy

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Pseudohypoxic pathways in renal cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Sunitinib versus interferon alfa in metastatic renal-cell carcinoma

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Sorafenib in advanced clear-cell renal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Inherited susceptibility to uterine leiomyomas and renal cell cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Familial cutaneous leiomyomatosis is a two-hit condition associated with renal cell cancer of characteristic histopathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Hereditary leiomyomatosis and renal cell cancer: a syndrome associated with an aggressive form of inherited renal cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome

21 January 2018

1 reference

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Analysis of the Birt-Hogg-Dubé (BHD) tumour suppressor gene in sporadic renal cell carcinoma and colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Clinical and genetic studies of Birt-Hogg-Dubé syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Expression of Birt-Hogg-Dubé gene mRNA in normal and neoplastic human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Correlation of renal ultrasonographic findings with inflammatory volume from dimercaptosuccinic acid renal scans in children with acute pyelonephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Hybrid chromophobe renal cell neoplasm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Activating mutations for the met tyrosine kinase receptor in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Novel mutations of the MET proto-oncogene in papillary renal carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Common pattern of unusual chromosome abnormalities in hereditary papillary renal carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

The Akt-mTOR tango and its relevance to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Upstream and downstream of mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Rheb fills a GAP between TSC and TOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

The tuberous sclerosis complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Identification and characterization of the tuberous sclerosis gene on chromosome 16

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Molecular genetics of renal carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Malignant renal tumors in tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Renal angiomyolipoma: long-term results after arterial embolization

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Efficacy of sirolimus in treating tuberous sclerosis and lymphangioleiomyomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Familial isolated hyperparathyroidism: clinical and genetic characteristics of 36 kindreds

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Hyperparathyroidism-jaw tumour syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Nuclear localization of the parafibromin tumor suppressor protein implicated in the hyperparathyroidism-jaw tumor syndrome enhances its proapoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Rapid mutation screening for HRPT2 and MEN1 mutations associated with familial and sporadic primary hyperparathyroidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Hereditary Renal-Cell Carcinoma Associated with a Chromosomal Translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Chromosome 3 translocations and familial renal cell cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Molecular cytogenetic analysis of clustered sporadic and familial renal cell carcinoma-associated 3q13 approximately q22 breakpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Hypoxic Regulation of Lactate Dehydrogenase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Identification of 54 large deletions/duplications in TSC1 and TSC2 using MLPA, and genotype-phenotype correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

Renal Tumors in the Birt-Hogg-Dubé Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.8.6.895

21 January 2018

Identifiers

DOI

10.1586/14737140.8.6.895

1 reference

18 August 2017

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