(Q37193593)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18560328%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

26 October 2020

Progress in drug delivery to the central nervous system by the prodrug approach (English)

1 reference

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9 January 2020

1 reference

1 reference

26 October 2020

0 references

1

1 reference

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9 January 2020

Stefano Manfredini

5

1 reference

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9 January 2020

Silvia Vertuani

6

1 reference

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9 January 2020

author name string

Alessandro Dalpiaz

2

1 reference

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9 January 2020

Nunzia Ciliberti

3

1 reference

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9 January 2020

Carla Biondi

4

1 reference

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9 January 2020

language of work or name

English

0 references

publication date

1 May 2008

2 references

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9 January 2020

26 October 2020

2 references

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9 January 2020

26 October 2020

13

1 reference

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9 January 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18560328%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

page(s)

1035-1065

1 reference

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Creative Commons Attribution

9 January 2020

copyright license

1 reference

26 October 2020

0 references

Simultaneous delivery of valproic acid and glycine to the brain. Deamination of 2-propylpentylglycinamide by monoamine oxidase B.

1 reference

12 December 2020

Enzyme-activated antagonists of the strychnine-insensitive glycine/NMDA receptor.

1 reference

12 December 2020

Prodrug strategies to overcome poor water solubility

1 reference

12 December 2020

Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds

1 reference

12 December 2020

Delivery of therapeutic agents to the central nervous system: the problems and the possibilities.

1 reference

12 December 2020

Determination of m-nitrophenol and nipecotic acid in mouse tissues by high-performance liquid chromatography after administration of the anticonvulsant m-nitrophenyl-3-piperidinecarboxylate hydrochloride.

1 reference

12 December 2020

Intranasal drug delivery for brain targeting.

1 reference

12 December 2020

Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents

1 reference

12 December 2020

Blood-brain barrier delivery

1 reference

12 December 2020

Synthesis and pharmacological properties of 2-[S-acetylthiorphan]-1,3- diacylaminopropan-2-ol derivatives as chimeric lipid drug carriers containing an enkephalinase inhibitor

1 reference

12 December 2020

Targeting drugs to the brain by redox chemical delivery systems.

1 reference

12 December 2020

Vitamin C and 6-amino-vitamin C conjugates of diclofenac: synthesis and evaluation.

1 reference

12 December 2020

Centrally acting and metabolically stable thyrotropin-releasing hormone analogues by replacement of histidine with substituted pyridinium.

1 reference

12 December 2020

Convulsant and anticonvulsant actions in DBA/2 mice of compounds blocking the reuptake of GABA

1 reference

12 December 2020

Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival

1 reference

12 December 2020

Prodrug based optimal drug delivery via membrane transporter/receptor

1 reference

12 December 2020

1 reference

12 December 2020

Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in mice

1 reference

12 December 2020

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

1 reference

12 December 2020

Drug targeting to the brain

1 reference

12 December 2020

Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations

1 reference

12 December 2020

Strategies to advance translational research into brain barriers

1 reference

12 December 2020

The blood-brain barrier: bottleneck in brain drug development

1 reference

12 December 2020

Synthesis and study of 5'-ester prodrugs of N6-cyclopentyladenosine, a selective A1 receptor agonist

1 reference

12 December 2020

Strategies to target kyotorphin analogues to the brain.

1 reference

12 December 2020

Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity.

1 reference

12 December 2020

Evaluation of brain-targeting for the nasal delivery of estradiol by the microdialysis method.

1 reference

12 December 2020

Molecular Trojan horses for blood-brain barrier drug delivery

1 reference

12 December 2020

Colloidal carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain?

1 reference

12 December 2020

Transport of steroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormone

1 reference

12 December 2020

A pyridinium-substituted analog of the TRH-like tripeptide pGlu-Glu-Pro-NH2 and its prodrugs as central nervous system agents

1 reference

12 December 2020

Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection

1 reference

12 December 2020

Blood-brain barrier permeation: molecular parameters governing passive diffusion

1 reference

12 December 2020

Prodrugs in nasal drug delivery

1 reference

12 December 2020

Synthesis and evaluation of the anti-inflammatory effects of niflumic acid lipophilic prodrugs in brain edema.

1 reference

12 December 2020

Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules.

1 reference

12 December 2020

Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma

1 reference

12 December 2020

Antiviral effects of phosphonoformate (PFA, foscarnet sodium).

1 reference

12 December 2020

Transport of drugs from the nasal cavity to the central nervous system

1 reference

12 December 2020

The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential

1 reference

12 December 2020

Molecular mechanism involved in the transport of a prodrug dopamine glycosyl conjugate

1 reference

12 December 2020

Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides

1 reference

12 December 2020

Stability of oxymethyl-modified coumarinic acid cyclic prodrugs of diastereomeric opioid peptides in biological media from various animal species including human

1 reference

12 December 2020

Azomethine prodrugs of (R)-alpha-methylhistamine, a highly potent and selective histamine H3-receptor agonist

1 reference

12 December 2020

Enhancement of the systemic and CNS specific delivery of L-dopa by the nasal administration of its water soluble prodrugs

1 reference

12 December 2020

Synthesis, stability, and pharmacological evaluation of nipecotic acid prodrugs.

1 reference

12 December 2020

Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization

1 reference

12 December 2020

Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity.

1 reference

12 December 2020

Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function

1 reference

12 December 2020

Is nose-to-brain transport of drugs in man a reality?

1 reference

12 December 2020

Transporter-mediated permeation of drugs across the blood-brain barrier

1 reference

12 December 2020

Nipecotic acid: systemic availability and brain delivery after nasal administration of nipecotic acid and n-butyl nipecotate to rats

1 reference

12 December 2020

Synthesis and characterization of 9-[P-(N, N-dipropyl sulfamide)] benzoylamino-1,2,3,4-4H-acridine--a potential prodrug for the CNS delivery of tacrine

1 reference

12 December 2020

Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man

1 reference

12 December 2020

Pharmacological properties of acetorphan, a parenterally active "enkephalinase" inhibitor.

1 reference

12 December 2020

Role of brain tissue localized purine metabolizing enzymes in the central nervous system delivery of anti-HIV agents 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats.

1 reference

12 December 2020

The role of drug transporters at the blood-brain barrier

1 reference

12 December 2020

The blood-brain barrier: principles for targeting peptides and drugs to the central nervous system

1 reference

12 December 2020

Kinetics of blood-brain transport of hexoses

1 reference

12 December 2020

In vitro culture of human retinal pigment epithelium for biochemical and metabolic study

1 reference

12 December 2020

Brain metabolism: a perspective from the blood-brain barrier

1 reference

12 December 2020

Glycosyl derivatives of dopamine and L-dopa as anti-Parkinson prodrugs: synthesis, pharmacological activity and in vitro stability studies

1 reference

12 December 2020

DP-155, a lecithin derivative of indomethacin, is a novel nonsteroidal antiinflammatory drug for analgesia and Alzheimer's disease therapy.

1 reference

12 December 2020

Proton transport across transient single-file water pores in a lipid membrane studied by molecular dynamics simulations

1 reference

12 December 2020

"Mixed inhibitor-prodrug" as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes

1 reference

12 December 2020

The blood-brain barrier and cancer: transporters, treatment, and Trojan horses

1 reference

12 December 2020

Facilitated brain uptake of 4-chlorokynurenine and conversion to 7-chlorokynurenic acid.

1 reference

12 December 2020

The gamma-hydroxybutyrate model of absence seizures: correlation of regional brain levels of gamma-hydroxybutyric acid and gamma-butyrolactone with spike wave discharges

1 reference

12 December 2020

Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2

1 reference

12 December 2020

Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability

1 reference

12 December 2020

Peptide drug delivery into the central nervous system.

1 reference

12 December 2020

Transporter-mediated effects of diclofenamic acid and its ascorbyl pro-drug in the in vivo neurotropic activity of ascorbyl nipecotic acid conjugate

1 reference

12 December 2020

A family of mammalian Na+-dependent L-ascorbic acid transporters

1 reference

12 December 2020

Blood-brain barrier drug targeting: the future of brain drug development

1 reference

12 December 2020

Ascorbate regulation and its neuroprotective role in the brain

1 reference

12 December 2020

Synthesis and evaluation of a redox chemical delivery system for brain-enhanced dopamine containing an activated carbamate-type ester

1 reference

12 December 2020

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

1 reference

12 December 2020

Molecular forces governing non-electrolyte permeation through cell membranes.

1 reference

12 December 2020

Ocular ascorbate transport and metabolism

1 reference

12 December 2020

Glucose transport in immortalized rat brain capillary endothelial cells in vitro: transport activity and GLUT1 expression

1 reference

12 December 2020

Pharmacokinetics of chlorambucil-tertiary butyl ester, a lipophilic chlorambucil derivative that achieves and maintains high concentrations in brain

1 reference

12 December 2020

Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids

1 reference

12 December 2020

Dosage form design for improvement of bioavailability of levodopa III: Influence of dose on pharmacokinetic behavior of levodopa in dogs and Parkinsonian patients

1 reference

12 December 2020

Improved brain delivery of a nonsteroidal anti-inflammatory drug with a synthetic glyceride ester: a preliminary attempt at a CNS drug delivery system for the therapy of Alzheimer's disease.

1 reference

12 December 2020

Design, synthesis, and biological evaluation of novel, centrally-acting thyrotropin-releasing hormone analogues.

1 reference

12 December 2020

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

12 December 2020

Blood-brain transfer of glucose and glucose analogs in newborn rats

1 reference

12 December 2020

Immunohistochemical localization of aminopeptidase M in rat brain and periphery: relationship of enzyme localization and enkephalin metabolism

1 reference

12 December 2020

Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.

1 reference

12 December 2020

Potential prodrugs of non-steroidal anti-inflammatory agents for targeted drug delivery to the CNS.

1 reference

12 December 2020

Antiepileptic drug pharmacokinetics and neuropharmacokinetics in individual rats by repetitive withdrawal of blood and cerebrospinal fluid: milacemide

1 reference

12 December 2020

Ascorbic and 6-Br-ascorbic acid conjugates as a tool to increase the therapeutic effects of potentially central active drugs.

1 reference

12 December 2020

Blood-Brain Barrier: Penetration of Morphine, Codeine, Heroin, and Methadone after Carotid Injection

1 reference

12 December 2020

Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)

1 reference

12 December 2020

Brain-targeted delivery of a leucine-enkephalin analogue by retrometabolic design.

1 reference

12 December 2020

A comparison of prodrug esters of nipecotic acid

1 reference

12 December 2020

Synthesis and biological investigations of 5-substituted pyrimidine nucleosides coupled to a dihydropyridine/pyridinium salt redox chemical delivery system

1 reference

12 December 2020

Enhanced brain delivery of an anti-HIV nucleoside 2'-F-ara-ddI by xanthine oxidase mediated biotransformation

1 reference

12 December 2020

New therapies for Parkinson's disease

1 reference

12 December 2020

Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development

1 reference

12 December 2020

Modifying peptide properties by prodrug design for enhanced transport into the CNS.

1 reference

12 December 2020

Anti-sunshine vitamin A

1 reference

12 December 2020

Levels of dopamine in blood and brain following nasal administration to rats

1 reference

12 December 2020

Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration

1 reference

12 December 2020

Analgesic potency of S-acetylthiorphan after intravenous administration to mice

1 reference

12 December 2020

Synthesis, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs

1 reference

12 December 2020

10.3390/MOLECULES13051035

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18560328%20AND%20SRC:MED&resulttype=core&format=json

release_kfxmexpng5bbfbciujzfcbr24i

9 January 2020

Fatcat ID

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Fatcat

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24 November 2022

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1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18560328%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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