(Q37200576)

18 August 2017

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title

The semaphorins: versatile regulators of tumour progression and tumour angiogenesis (English)

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18 August 2017

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Gera Neufeld

1

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18 August 2017

Ofra Kessler

series ordinal

2

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18 August 2017

language of work or name

English

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publication date

26 June 2008

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18 August 2017

Nature Reviews Cancer

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18 August 2017

8

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18 August 2017

632-645

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18 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrc2404

18 August 2017

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cites work

Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165.

1 reference

Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis

21 January 2018

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Semaphorin SEMA3F and VEGF have opposing effects on cell attachment and spreading

21 January 2018

1 reference

Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype

21 January 2018

1 reference

Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones

21 January 2018

1 reference

Unified nomenclature for the semaphorins/collapsins. Semaphorin Nomenclature Committee

31 March 2020

1 reference

31 March 2020

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A 70 amino acid region within the semaphorin domain activates specific cellular response of semaphorin family members

31 March 2020

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Domains in plexins: links to integrins and transcription factors

31 March 2020

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Interactions between growth factor receptors and adhesion molecules: breaking the rules

31 March 2020

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Collapsin-1 covalently dimerizes, and dimerization is necessary for collapsing activity.

31 March 2020

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The chemorepulsive activity of the axonal guidance signal semaphorin D requires dimerization

31 March 2020

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MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D.

31 March 2020

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The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras

31 March 2020

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Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain

31 March 2020

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Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho.

31 March 2020

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The semaphorin 3A receptor may directly regulate the activity of small GTPases.

31 March 2020

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The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

31 March 2020

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The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG

31 March 2020

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Characterization of Insulin Inhibition of Transactivation by a C-terminal Fragment of the Forkhead Transcription Factor Foxo1 in Rat Hepatoma Cells

31 March 2020

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Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology

31 March 2020

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Functional regulation of semaphorin receptors by proprotein convertases

31 March 2020

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Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors

31 March 2020

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Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates

31 March 2020

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The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors.

31 March 2020

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Neuropilin is a receptor for the axonal chemorepellent Semaphorin III

31 March 2020

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Neuropilin is a semaphorin III receptor

31 March 2020

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Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity

31 March 2020

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Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III

31 March 2020

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Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B

31 March 2020

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Dual functional activity of semaphorin 3B is required for positioning the anterior commissure

31 March 2020

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Transmembrane domain interactions control biological functions of neuropilin-1

31 March 2020

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Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165

31 March 2020

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Structural basis for ligand and heparin binding to neuropilin B domains

31 March 2020

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Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration

31 March 2020

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Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling

31 March 2020

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Selective binding of VEGF121 to one of the three vascular endothelial growth factor receptors of vascular endothelial cells

31 March 2020

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Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

31 March 2020

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Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]

31 March 2020

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Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes

31 March 2020

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VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding

31 March 2020

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Neuropilin-1 and neuropilin-2 enhance VEGF121 stimulated signal transduction by the VEGFR-2 receptor

31 March 2020

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Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration

31 March 2020

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Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting.

31 March 2020

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Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival

31 March 2020

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Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity.

31 March 2020

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Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins

31 March 2020

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Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

31 March 2020

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Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis

31 March 2020

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Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1

31 March 2020

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Neuropilin-1 is a placenta growth factor-2 receptor

31 March 2020

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A model for gene therapy of human hereditary lymphedema

31 March 2020

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Functional interaction of VEGF-C and VEGF-D with neuropilin receptors

31 March 2020

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Breast cancer cells secreted platelet-derived growth factor-induced motility of vascular smooth muscle cells is mediated through neuropilin-1.

31 March 2020

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Endothelial/pericyte interactions

31 March 2020

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Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2.

31 March 2020

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Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells

31 March 2020

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Analysis of the L1-deficient mouse phenotype reveals cross-talk between Sema3A and L1 signaling pathways in axonal guidance

31 March 2020

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Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A.

31 March 2020

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Close homolog of L1 and neuropilin 1 mediate guidance of thalamocortical axons at the ventral telencephalon.

31 March 2020

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Neuropilin-1 interacts with integrin beta1 and modulates pancreatic cancer cell growth, survival and invasion

31 March 2020

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The role of neuropilins in cancer

31 March 2020

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Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression

31 March 2020

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Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors

31 March 2020

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Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver

31 March 2020

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Plexin D1 expression is induced on tumor vasculature and tumor cells: a novel target for diagnosis and therapy?

31 March 2020

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Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins

31 March 2020

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Profiling estrogen-regulated gene expression changes in normal and malignant human ovarian surface epithelial cells.

31 March 2020

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Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts

31 March 2020

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Plexin-B1 mutations in prostate cancer

31 March 2020

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Poor outcome in estrogen receptor-positive breast cancers predicted by loss of plexin B1

31 March 2020

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Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors

31 March 2020

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High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene

31 March 2020

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The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-Americans

31 March 2020

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Null and conditionalsemaphorin 3B alleles using a flexiblepuro?tk loxP/FRT vector

31 March 2020

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Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect

31 March 2020

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Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer

31 March 2020

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Semaphorin SEMA3F has a repulsing activity on breast cancer cells and inhibits E-cadherin-mediated cell adhesion

31 March 2020

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Semaphorin SEMA3F affects multiple signaling pathways in lung cancer cells.

31 March 2020

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Selective suppression of in vivo tumorigenicity by semaphorin SEMA3F in lung cancer cells

31 March 2020

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Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: increased ratio of vascular endothelial growth factor to semaphorin is a poor p

31 March 2020

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Association of axon guidance factor Semaphorin 3A with poor outcome in pancreatic cancer

31 March 2020

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Cross-talk between vascular endothelial growth factor and semaphorin-3A pathway in the regulation of normal and malignant mesothelial cell proliferation

31 March 2020

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Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor

31 March 2020

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Identification of semaphorin E gene expression in metastatic human lung adenocarcinoma cells by mRNA differential display

31 March 2020

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Semaphorin 3C regulates endothelial cell function by increasing integrin activity

31 March 2020

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The semaphorin 4D receptor controls invasive growth by coupling with Met

31 March 2020

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Interplay between scatter factor receptors and B plexins controls invasive growth

31 March 2020

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Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway

31 March 2020

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EGF-ERBB signalling: towards the systems level

31 March 2020

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Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

31 March 2020

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ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1.

31 March 2020

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Plexin-B3 is a functional receptor for semaphorin 5A.

31 March 2020

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CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells

31 March 2020

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Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function

31 March 2020

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Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis

31 March 2020

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Selective requirements for NRP1 ligands during neurovascular patterning

31 March 2020

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Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development

31 March 2020

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Semaphorin-3F is an inhibitor of tumor angiogenesis.

31 March 2020

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Possible role of semaphorin 3F, a candidate tumor suppressor gene at 3p21.3, in p53-regulated tumor angiogenesis suppression

31 March 2020

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Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins

31 March 2020

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PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development

31 March 2020

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Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development.

31 March 2020

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Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1

31 March 2020

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Recombinant semaphorin 6A-1 ectodomain inhibits in vivo growth factor and tumor cell line-induced angiogenesis

31 March 2020

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Blocking neuropilin-2 function inhibits tumor cell metastasis

31 March 2020

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Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury

31 March 2020

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Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B.

31 March 2020

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Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis.

31 March 2020

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Sema4D induces angiogenesis through Met recruitment by Plexin B1

31 March 2020

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Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis

31 March 2020

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Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2

31 March 2020

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Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth

31 March 2020

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Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1.

31 March 2020

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CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival

31 March 2020

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CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes

31 March 2020

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Proprotein convertases: "master switches" in the regulation of tumor growth and progression

31 March 2020

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The chemorepulsive activity of secreted semaphorins is regulated by furin-dependent proteolytic processing

31 March 2020

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Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis

31 March 2020

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Semaphorin-3A guides radial migration of cortical neurons during development.

31 March 2020

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Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins.

31 March 2020

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Plexina1 autoinhibition by the plexin sema domain.

31 March 2020

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FARP2 triggers signals for Sema3A-mediated axonal repulsion

31 March 2020

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R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis

31 March 2020

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Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse.

31 March 2020

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Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

31 March 2020

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Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.

31 March 2020

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Lim kinases, regulators of actin dynamics

31 March 2020

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Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling

31 March 2020

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The Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons

31 March 2020

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Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex

31 March 2020

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Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease.

31 March 2020

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Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones

31 March 2020

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Collapsin response mediator protein switches RhoA and Rac1 morphology in N1E-115 neuroblastoma cells and is regulated by Rho kinase

31 March 2020

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MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion

31 March 2020

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MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat.

31 March 2020

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Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein

31 March 2020

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RanBPM contributes to Semaphorin3A signaling through plexin-A receptors

31 March 2020

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The organization of F-actin and microtubules in growth cones exposed to a brain-derived collapsing factor

31 March 2020

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Semaphorins as mediators of neuronal apoptosis.

31 March 2020

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Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor.

31 March 2020

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Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility

31 March 2020

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p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling

31 March 2020

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Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse

31 March 2020

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CRMP-2 binds to tubulin heterodimers to promote microtubule assembly

31 March 2020

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Semaphorin signaling in the immune system

31 March 2020

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Immune semaphorins: increasing members and their diverse roles.

31 March 2020

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Semaphorin-3A is expressed by tumor cells and alters T-cell signal transduction and function

31 March 2020

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31 March 2020

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Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2.

31 March 2020

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Identification of CD72 as a Lymphocyte Receptor for the Class IV Semaphorin CD100

31 March 2020

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Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans

31 March 2020

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A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis

31 March 2020

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Regulation of angiogenesis by Eph-ephrin interactions

31 March 2020

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Neogenin: one receptor, many functions

31 March 2020

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Role of neural guidance signals in blood vessel navigation

31 March 2020

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Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers

31 March 2020

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Potential role of the Slit/Robo signal pathway in angiogenesis.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC2404

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Dimensions Publication ID

18 August 2017

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