(Q37208033)

18 August 2017

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title

The moonlighting enzyme CD13: old and new functions to target (English)

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18 August 2017

Paola Mina-Osorio

1

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18 August 2017

publication date

5 July 2008

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Trends in Molecular Medicine

18 August 2017

published in

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18 August 2017

volume

14

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18 August 2017

issue

8

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18 August 2017

page(s)

361-371

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Caveolae/lipid rafts in fibroblast-like synoviocytes: ectopeptidase-rich membrane microdomains

18 August 2017

cites work

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12 December 2020

Galectin-4 and small intestinal brush border enzymes form clusters

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12 December 2020

Endogenous aminopeptidase N decreases the potency of peptide agonists and antagonists of the kinin B1 receptors in the rabbit aorta

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12 December 2020

CD13/aminopeptidase N-induced lymphocyte involvement in inflamed joints of patients with rheumatoid arthritis

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12 December 2020

Detection of cytotoxic CD13-specific autoantibodies in sera from patients with ulcerative colitis and Crohn's disease

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12 December 2020

Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer

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12 December 2020

Association of aminopeptidase N and endopeptidase 24.15 inhibitors potentiate behavioral effects mediated by nociceptin/orphanin FQ in mice

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12 December 2020

Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13).

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12 December 2020

The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors

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12 December 2020

Progress in the development of aminopeptidase N (APN/CD13) inhibitors

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12 December 2020

CD-13 (‘gp150’; aminopeptidase-N): Co-expression on endothelial and haemopoietic cells with conservation of functional activity

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12 December 2020

Hemorphins inhibit angiotensin IV binding and interact with aminopeptidase N

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12 December 2020

Aminopeptidase N-mediated signal transduction and inhibition of proliferation of human myeloid cells.

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12 December 2020

A phase I clinical trial of flavone-8-acetic acid in combination with interleukin 2

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12 December 2020

Regulation of the CD13/aminopeptidase N gene by DMP1, a transcription factor antagonized by D-type cyclins

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12 December 2020

An improved procedure for the generation of recombinant single-chain Fv antibody fragments reacting with human CD13 on intact cells

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12 December 2020

Membrane bound members of the M1 family: more than aminopeptidases

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12 December 2020

Identification of a 130-kilodalton human biliary concanavalin A binding protein as aminopeptidase N

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12 December 2020

Aminopeptidase inhibitor ubenimex (bestatin) inhibits the growth of human choriocarcinoma in nude mice through its direct cytostatic activity.

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12 December 2020

Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease

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12 December 2020

Enkephalin-degrading enzymes in normal and subfertile human semen

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12 December 2020

Cell-surface enzymes in control of leukocyte trafficking

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12 December 2020

Co-expression of haemopoietic antigens on vascular endothelial cells: a detailed phenotypic analysis

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12 December 2020

Deletion of the zinc-binding motif of CD13/aminopeptidase N molecules results in loss of epitopes that mediate binding of inhibitory antibodies

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12 December 2020

A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells

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12 December 2020

Modification of the amino terminus of a class II epitope confers resistance to degradation by CD13 on dendritic cells and enhances presentation to T cells

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12 December 2020

Effect of ubenimex (Bestatin) on the cell growth and phenotype of HL-60 and HL-60R cell lines: up-and down-regulation of CD13/aminopeptidase N

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12 December 2020

Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane

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12 December 2020

Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration

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12 December 2020

T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides

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12 December 2020

A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins

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12 December 2020

Aminopeptidase N (APN/CD13) is selectively expressed in vascular endothelial cells and plays multiple roles in angiogenesis

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12 December 2020

Antisense-mediated inhibition of aminopeptidase N (CD13) markedly decreases growth rates of hematopoietic tumour cells

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12 December 2020

Families of zinc metalloproteases.

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12 December 2020

Variable O-glycosylation of CD13 (aminopeptidase N).

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12 December 2020

Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells

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12 December 2020

Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy

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12 December 2020

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

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12 December 2020

Single site polymorphisms and alternative splicing of the human CD13 gene--different splicing frequencies among patients with acute myeloid leukaemia and healthy individuals

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12 December 2020

Metabolism of vasoactive peptides by plasma and purified renal aminopeptidase M.

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12 December 2020

Impaired angiogenesis in aminopeptidase N-null mice

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12 December 2020

Cholesterol crystallization-promoting activity of aminopeptidase-N isolated from the vesicular carrier of biliary lipids.

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12 December 2020

CD13 in cell adhesion: aminopeptidase N (CD13) mediates homotypic aggregation of monocytic cells.

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12 December 2020

Mutational analysis of aminopeptidase N, a receptor for several group 1 coronaviruses, identifies key determinants of viral host range

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12 December 2020

Aminopeptidase N (CD13) functionally interacts with FcγRs in human monocytes

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12 December 2020

IL-10 and TGF-beta differ in their regulation of aminopeptidase N/CD13 expression in monocytes.

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12 December 2020

A role for galectin-3 in CD13-mediated homotypic aggregation of monocytes

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12 December 2020

Soluble aminopeptidase N/CD13 in malignant and nonmalignant effusions and intratumoral fluid

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12 December 2020

Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation

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12 December 2020

Feline aminopeptidase N is a receptor for all group I coronaviruses

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12 December 2020

Biological significance of aminopeptidase N/CD13 in thyroid carcinomas.

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12 December 2020

Moonlighting proteins: old proteins learning new tricks.

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12 December 2020

Molecular analysis of the coronavirus-receptor function of aminopeptidase N.

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12 December 2020

Induction of apoptosis by bestatin (ubenimex) in human leukemic cell lines

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12 December 2020

Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature-specific ligands potentiates therapeutic efficacy

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12 December 2020

Synergistic antitumor activity of cisplatin, paclitaxel, and gemcitabine with tumor vasculature-targeted tumor necrosis factor-alpha

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12 December 2020

Aminopeptidase N (CD13) is a molecular target of the cholesterol absorption inhibitor ezetimibe in the enterocyte brush border membrane

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12 December 2020

Continuous treatment of bestatin induces anti-angiogenic property in endothelial cells.

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12 December 2020

Cryptic and regulatory epitopes in CD13/aminopeptidase N

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12 December 2020

1,25-dihydroxyvitamin D3 stimulates phagocytosis but suppresses HLA-DR and CD13 antigen expression in human mononuclear phagocytes

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12 December 2020

Neutralization of human cytomegalovirus by human CD13-specific antibodies

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12 December 2020

Myeloid antigen, CD13, CD14, and/or CD33 expression is restricted to certain lymphoid neoplasms

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12 December 2020

Ectopeptidases in tumour biology: a review

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12 December 2020

CD13/aminopeptidase N, a novel chemoattractant for T lymphocytes in pulmonary sarcoidosis

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12 December 2020

Identification of CD13+CD36+ cells as a common progenitor for erythroid and myeloid lineages in human bone marrow

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12 December 2020

Synergistic damage of tumor vessels with ultra low-dose endothelial-monocyte activating polypeptide-II and neovasculature-targeted tumor necrosis factor-alpha

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12 December 2020

Ezetimib influences the expression of raft-associated antigens in human monocytes

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12 December 2020

Crystal structure of aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli and conformational change of methionine 260 involved in substrate recognition.

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12 December 2020

Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis

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12 December 2020

A Mutation in Aminopeptidase N (CD13) Isolated from a Patient Suffering from Leukemia Leads to an Arrest in the Endoplasmic Reticulum

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12 December 2020

Seminal plasma leucine aminopeptidase in male fertility.

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12 December 2020

Signal regulators in FcR-mediated activation of leukocytes?

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12 December 2020

cNGR: a novel homing sequence for CD13/APN targeted molecular imaging of murine cardiac angiogenesis in vivo

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12 December 2020

Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II. Insights into omega-versus aminopeptidase specificity in the M1 family

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12 December 2020

CD13/APN is activated by angiogenic signals and is essential for capillary tube formation

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12 December 2020

Structure and expression of aminopeptidase N.

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12 December 2020

Aminopeptidase N is involved in cell motility and angiogenesis: its clinical significance in human colon cancer

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12 December 2020

Aminopeptidase N/CD13 is directly linked to signal transduction pathways in monocytes

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12 December 2020

Dipeptidyl peptidase IV (CD 26) and aminopeptidase N (CD 13) catalyzed hydrolysis of cytokines and peptides with N-terminal cytokine sequences

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12 December 2020

The human aminopeptidase N gene: isolation, chromosome localization, and DNA polymorphism analysis

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12 December 2020

Novel molecular mechanisms of dendritic cell-induced T cell activation.

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12 December 2020

Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.

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12 December 2020

Structure and function of aminopeptidase N.

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12 December 2020

CD13 is a novel mediator of monocytic/endothelial cell adhesion

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12 December 2020

Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses

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12 December 2020

Conformational change of rabbit aminopeptidase N into enterocyte plasma membrane domains analyzed by flow cytometry fluorescence energy transfer.

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12 December 2020

Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13)--a novel approach for the treatment of inflammatory bowel disease.

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12 December 2020

Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3.

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12 December 2020

Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site

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12 December 2020

CD13 (human aminopeptidase N) mediates human cytomegalovirus infection

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12 December 2020

Molecular determinants of species specificity in the coronavirus receptor aminopeptidase N (CD13): influence of N-linked glycosylation.

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12 December 2020

Aminopeptidase N (APN)/CD13-dependent CXCR4 downregulation is associated with diminished cell migration, proliferation and invasion

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12 December 2020

CD13--not just a marker in leukemia typing

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12 December 2020

High-molecular-mass isoform of aminopeptidase N/CD13 in serum from cholestatic patients

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12 December 2020

Aminopeptidase N in arterial hypertension

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12 December 2020

Tumor vascular targeting with tumor necrosis factor alpha and chemotherapeutic drugs

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12 December 2020

Aminopeptidase N in sera of healthy subjects is a different N-terminal processed derivative from the one obtained from maternal serum

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12 December 2020

CD13/aminopeptidase N in collagen vascular diseases

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12 December 2020

Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13

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12 December 2020

CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated.

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12 December 2020

Aminopeptidase inhibitors bestatin and actinonin inhibit cell proliferation of myeloma cells predominantly by intracellular interactions

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12 December 2020

CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells

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12 December 2020

Transmembrane proteases in cell growth and invasion: new contributors to angiogenesis?

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12 December 2020

Human coronavirus 229E binds to CD13 in rafts and enters the cell through caveolae

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12 December 2020

Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells.

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12 December 2020

CD13/APN regulates endothelial invasion and filopodia formation

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12 December 2020

Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics

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12 December 2020

Rapid extracellular degradation of synthetic class I peptides by human dendritic cells

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12 December 2020

Substance P and bradykinin are natural inhibitors of CD13/aminopeptidase N.

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12 December 2020

Flow cytometric technique for determination of prostasomal quantity, size and expression of CD10, CD13, CD26 and CD59 in human seminal plasma

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12 December 2020

The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways

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12 December 2020

10.1016/J.MOLMED.2008.06.003

Identifiers

DOI

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18 August 2017

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