(Q37213940)

19 August 2017

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title

Tuberculosis vaccine development: goals, immunological design, and evaluation (English)

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19 August 2017

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1 reference

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Daniel F Hoft

1

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PubMed ID

18620952

19 August 2017

language of work or name

English

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publication date

1 July 2008

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19 August 2017

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19 August 2017

372

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19 August 2017

9633

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19 August 2017

164-175

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Immune response toMycobacterium bovis bacille Calmette Guérin infection in major histocompatibility complex class I- and II-deficient knock-out mice: contribution of CD4 and CD8 T cells to acquired resistance

19 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

CD4+ T cells mediate IFN-gamma-independent control of Mycobacterium tuberculosis infection both in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

CD4+ and CD8+ T cells mediate adoptive immunity to aerosol infection of Mycobacterium bovis bacillus Calmette-Guérin

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Contribution of Th1 and Th2 cells to protection and pathology in experimental models of granulomatous lung disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

CD4(+) T-cell subsets that mediate immunological memory to Mycobacterium tuberculosis infection in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Tuberculosis in HIV-infected patients: a comprehensive review.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Functional diversity of helper T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Interleukin-23 restores immunity to Mycobacterium tuberculosis infection in IL-12p40-deficient mice and is not required for the development of IL-17-secreting T cell responses

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Experimental approaches to mechanisms of protection and pathogenesis in M. tuberculosis infection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Mycobacterium tuberculosis-reactive CD8+ T lymphocytes: the relative contribution of classical versus nonclassical HLA restriction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Control of latent Mycobacterium tuberculosis infection is dependent on CD8 T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

An antimicrobial activity of cytolytic T cells mediated by granulysin

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Selective expansion of human gamma delta T cells by monocytes infected with live Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

The primary response of human gamma/delta + T cells to Mycobacterium tuberculosis is restricted to V gamma 9-bearing cells

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective Mycobacterium tuberculosis immunity.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Gammadelta T cells: functional plasticity and heterogeneity

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Phosphate is essential for stimulation of V gamma 9V delta 2 T lymphocytes by mycobacterial low molecular weight ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Stimulation of human gamma delta T cells by nonpeptidic mycobacterial ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Natural and synthetic non-peptide antigens recognized by human gamma delta T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

3-Formyl-1-butyl pyrophosphate A novel mycobacterial metabolite-activating human gammadelta T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Isopentenyl pyrophosphate, a mycobacterial non-peptidic antigen, triggers delayed and highly sustained signaling in human gamma delta T lymphocytes without inducing eown-modulation of T cell antigen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Differential effects of cytolytic T cell subsets on intracellular infection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Induction of CD1-restricted immune responses in guinea pigs by immunization with mycobacterial lipid antigens

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Immunization with a mycobacterial lipid vaccine improves pulmonary pathology in the guinea pig model of tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

T-cell responses to CD1-presented lipid antigens in humans with Mycobacterium tuberculosis infection

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Lipoarabinomannan-reactive human secretory immunoglobulin A responses induced by mucosal bacille Calmette-Guérin vaccination

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Enhancement of innate and cell-mediated immunity by antimycobacterial antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

A mAb recognizing a surface antigen of Mycobacterium tuberculosis enhances host survival

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Single intranasal mucosal Mycobacterium bovis BCG vaccination confers improved protection compared to subcutaneous vaccination against pulmonary tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Mechanisms of mucosal and parenteral tuberculosis vaccinations: adenoviral-based mucosal immunization preferentially elicits sustained accumulation of immune protective CD4 and CD8 T cells within the airway lumen.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Chemokines in tissue-specific and microenvironment-specific lymphocyte homing

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Natural regulatory T cells in infectious disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Cutting Edge: Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

A role for CD4+CD25+ T cells in regulation of the immune response during human tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Immunosuppression during active tuberculosis is characterized by decreased interferon- gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor- beta , and interleukin-4 mRNA levels

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Regulatory T cells and mechanisms of immune system control

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Human T regulatory cells can use the perforin pathway to cause autologous target cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Antagonistic effects of an alternative splice variant of human IL-4, IL-4delta2, on IL-4 activities in human monocytes and B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

IL-4 in tuberculosis: implications for vaccine design

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

CCR7 expression and memory T cell diversity in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Cytokine control of memory T-cell development and survival

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Recombinant bacillus calmette-guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Boosting with poxviruses enhances Mycobacterium bovis BCG efficacy against tuberculosis in guinea pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10)

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Large-scale evaluation of enzyme-linked immunospot assay and skin test for diagnosis of Mycobacterium tuberculosis infection against a gradient of exposure in The Gambia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Quantitative T cell assay reflects infectious load of Mycobacterium tuberculosis in an endemic case contact model

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

ESAT-6/CFP-10 fusion protein and peptides for optimal diagnosis of mycobacterium tuberculosis infection by ex vivo enzyme-linked immunospot assay in the Gambia

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Molecular characterization and human T-cell responses to a member of a novel Mycobacterium tuberculosis mtb39 gene family.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Prospects for a better vaccine against tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Mycobacterium bovis BCG response regulator essential for hypoxic dormancy

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Two sensor kinases contribute to the hypoxic response of Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Dormancy phenotype displayed by extracellular Mycobacterium tuberculosis within artificial granulomas in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Therapy of tuberculosis in mice by DNA vaccination.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immunized with vaccines directed against the hsp60 molecule of Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Safety and Immunogenicity of a Five-Dose Series of Inactivated Mycobacterium vaccae Vaccination for the Prevention of HIV-Associated Tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Recombinant Mycobacterium bovis BCG secreting functional interleukin-2 enhances gamma interferon production by splenocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Manipulation and potentiation of antimycobacterial immunity using recombinant bacille Calmette-Guérin strains that secrete cytokines

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

IL-2-secreting recombinant bacillus Calmette Guerin can overcome a Type 2 immune response and corticosteroid-induced immunosuppression to elicit a Type 1 immune response

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Cytolytic T-cell responses to human dendritic cells and macrophages infected with Mycobacterium bovis BCG and recombinant BCG secreting listeriolysin

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Disseminated bacille Calmette-Guérin disease after vaccination: case report and review

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Clinical reactogenicity of intradermal bacille Calmette-Guérin vaccination

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Differential immunogenicity of various heterologous prime-boost vaccine regimens using DNA and viral vectors in healthy volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Mucosal bacille calmette-Guérin vaccination of humans inhibits delayed-type hypersensitivity to purified protein derivative but induces mycobacteria-specific interferon-gamma responses

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

The tuberculosis vaccine challenge

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Safety issues regarding new vaccines for tuberculosis, with an emphasis on post-exposure vaccination

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Evaluation of Human Antimycobacterial Immunity Using Recombinant Reporter Mycobacteria

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Differential effects of control and antigen-specific T cells on intracellular mycobacterial growth

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

Persistence and boosting of bacille Calmette-Guérin-induced delayed-type hypersensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2808%2961036-3

7 January 2021

10.1016/S0140-6736(08)61036-3

Identifiers

DOI

1 reference

19 August 2017

1 reference

PubMed ID

18620952