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DNA polymerases as therapeutic targets
scientific article published on 19 July 2008
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Europe PubMed Central
PMCID
2692436
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19 August 2017
review article
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Europe PubMed Central
title
DNA polymerases as therapeutic targets
(English)
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Europe PubMed Central
PMCID
2692436
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19 August 2017
author name string
Anthony J Berdis
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1
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Europe PubMed Central
PMCID
2692436
retrieved
19 August 2017
language of work or name
English
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publication date
19 July 2008
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Europe PubMed Central
PMCID
2692436
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19 August 2017
published in
Biochemistry
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Europe PubMed Central
PMCID
2692436
retrieved
19 August 2017
volume
47
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Europe PubMed Central
PMCID
2692436
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19 August 2017
issue
32
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Europe PubMed Central
PMCID
2692436
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19 August 2017
page(s)
8253-8260
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Europe PubMed Central
PMCID
2692436
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19 August 2017
cites work
Mechanism and dynamics of translesion DNA synthesis catalyzed by the Escherichia coli Klenow fragment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
6 September 2017
Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase by a stavudine analogue, 4'-ethynyl stavudine triphosphate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
6 September 2017
The involvement of DNA-damage and -repair defects in neurological dysfunction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
6 September 2017
Influence of DNA damage and repair upon the risk of treatment related leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
6 September 2017
Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
6 September 2017
Nucleoside analogue delivery systems in cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
6 September 2017
Fludarabine: a review of its use in non-Hodgkin's lymphoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
6 September 2017
The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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Etoposide, topoisomerase II and cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
6 September 2017
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
6 September 2017
Can modulation of viral fitness represent a target for anti-HIV-1 strategies?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
6 September 2017
Antivirals against DNA viruses (hepatitis B and the herpes viruses).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
6 September 2017
Pharmacokinetic properties of nucleoside/nucleotide reverse transcriptase inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
6 September 2017
Anticancer Antifolates: Current Status and Future Directions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
6 September 2017
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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stated in
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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stated in
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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stated in
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reference URL
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retrieved
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1 reference
stated in
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
PubMed Central
reference URL
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retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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stated in
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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stated in
PubMed Central
reference URL
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retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692436
retrieved
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1 reference
stated in
PubMed Central
reference URL
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retrieved
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1 reference
stated in
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reference URL
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retrieved
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1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18642851
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
CpG island methylator phenotype in cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18642851
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A potential chemotherapeutic strategy for the selective inhibition of promutagenic DNA synthesis by nonnatural nucleotides
1 reference
stated in
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reference URL
https://pubmed.ncbi.nlm.nih.gov/18642851
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Transcriptional and posttranscriptional regulation of H1 histone gene expression by 1-beta-D-arabinofuranosylcytosine
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stated in
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reference URL
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retrieved
12 December 2020
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Identifiers
DOI
10.1021/BI801179F
1 reference
stated in
Europe PubMed Central
PMCID
2692436
retrieved
19 August 2017
PMCID
2692436
1 reference
stated in
Europe PubMed Central
PMCID
2692436
retrieved
19 August 2017
PubMed ID
18642851
1 reference
stated in
Europe PubMed Central
PMCID
2692436
retrieved
19 August 2017
ResearchGate publication ID
51416885
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