(Q37224463)

19 August 2017

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title

Gastrointestinal stromal tumors: past, present, and future (English)

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19 August 2017

Yukihiko Kitamura

1

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19 August 2017

23 July 2008

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Journal of Gastroenterology

19 August 2017

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19 August 2017

43

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19 August 2017

499-508

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19 August 2017

7

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A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in their oncogenesis

19 August 2017

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https://api.crossref.org/works/10.1007%2FS00535-008-2200-Y

Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00535-008-2200-Y

Activating c-kit gene mutations in human germ cell tumors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00535-008-2200-Y

KIT mutations are common in testicular seminomas

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00535-008-2200-Y

KIT mutations are common in incidental gastrointestinal stromal tumors one centimeter or less in size

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-008-2200-Y

KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00535-008-2200-Y

Mutations in exons 9 and 13 of KIT gene are rare events in gastrointestinal stromal tumors. A study of 200 cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-008-2200-Y

Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-008-2200-Y

The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00535-008-2200-Y

Gastrointestinal stromal tumour treated with neoadjuvant imatinib

21 January 2018

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12 December 2020

STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications

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12 December 2020

Cause of familial and multiple gastrointestinal autonomic nerve tumors with hyperplasia of interstitial cells of Cajal is germline mutation of the c-kit gene

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12 December 2020

Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm

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12 December 2020

Hereditary anemias of the mouse: a review for geneticists

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12 December 2020

Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation

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12 December 2020

Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa

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12 December 2020

PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KIT-negative tumors

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12 December 2020

Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor

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12 December 2020

Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma

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12 December 2020

Interstitial cells of Cajal generate a rhythmic pacemaker current

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12 December 2020

Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours

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12 December 2020

Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors

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12 December 2020

Novel NF1 gene mutation in a Japanese patient with neurofibromatosis type 1 and a gastrointestinal stromal tumor.

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12 December 2020

Gastric stromal tumors. Reappraisal of histogenesis

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12 December 2020

Systemic mastocytosis

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12 December 2020

Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

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12 December 2020

Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis

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12 December 2020

Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach.

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12 December 2020

Biology of gastrointestinal stromal tumors.

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12 December 2020

A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors

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12 December 2020

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

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12 December 2020

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

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12 December 2020

PDGFRA activating mutations in gastrointestinal stromal tumors.

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12 December 2020

Successful resection of an advanced duodenal gastrointestinal stromal tumor after down-staging with imatinib: report of a case

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12 December 2020

Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse

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12 December 2020

Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation

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12 December 2020

Kit as a human oncogenic tyrosine kinase

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12 December 2020

Pathophysiology, diagnosis, and treatment of gastrointestinal stromal tumors

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12 December 2020

Targeting c-Kit mutations: basic science to novel therapies

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12 December 2020

Clonal evolution of resistance to imatinib in patients with metastatic gastrointestinal stromal tumors

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12 December 2020

Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants.

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12 December 2020

Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit gene

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12 December 2020

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand

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12 December 2020

A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors

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12 December 2020

Gastrointestinal stromal tumors (GIST): a model for molecule-based diagnosis and treatment of solid tumors

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12 December 2020

Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor

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12 December 2020

Requirement of c-kit for development of intestinal pacemaker system

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12 December 2020

Spleen colony-forming cell as common precursor for tissue mast cells and granulocytes

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12 December 2020

Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal

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12 December 2020

A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E.

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12 December 2020

Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients.

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12 December 2020

Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor.

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12 December 2020

Alterations of the c-kit gene in testicular germ cell tumors

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12 December 2020

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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12 December 2020

Surgical management after neoadjuvant imatinib therapy in gastrointestinal stromal tumours (GISTs) with respect to imatinib resistance caused by secondary KIT mutations

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12 December 2020

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

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12 December 2020

Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase

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12 December 2020

Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines.

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12 December 2020

STI571: targeting BCR-ABL as therapy for CML.

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12 December 2020

Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene

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12 December 2020

Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats

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12 December 2020

Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis

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12 December 2020

A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy.

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12 December 2020

PDGFRA germline mutation in a family with multiple cases of gastrointestinal stromal tumor

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12 December 2020

Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate

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12 December 2020

Heterogeneity of mast cells and phenotypic change between subpopulations

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12 December 2020

Absence of c-kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients

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12 December 2020

W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity

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12 December 2020

Kit receptor dimerization is driven by bivalent binding of stem cell factor

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12 December 2020

Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W

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12 December 2020

Development of mast cells from grafted bone marrow cells in irradiated mice

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12 December 2020

Decreased production of mast cells in S1/S1d anemic mice

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12 December 2020

Combined surgical and molecular therapy: the gastrointestinal stromal tumor model

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12 December 2020

Spectrum of associated clonal hematologic non-mast cell lineage disorders occurring in patients with systemic mastocytosis.

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12 December 2020

Steel locus defines new multipotent growth factor

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12 December 2020

Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family

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12 December 2020

Coincidental development of forestomach papilloma and prepyloric ulcer in nontreated mutant mice of W/Wv and SI/SId genotypes

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12 December 2020

A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family.

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12 December 2020

Epithelioid gastric stromal tumours of the antrum in young females with the Carney triad: a report of three new cases with mutational analysis and comparative genomic hybridization

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12 December 2020

Structure of a c-kit product complex reveals the basis for kinase transactivation

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12 December 2020

Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours

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12 December 2020

Anemia and mast cell depletion in mutant rats that are homozygous at "white spotting (Ws)" locus

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12 December 2020

KIT activation is a ubiquitous feature of gastrointestinal stromal tumors

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12 December 2020

Characterization of Ws mutant allele of rats: a 12-base deletion in tyrosine kinase domain of c-kit gene.

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12 December 2020

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

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12 December 2020

Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.

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12 December 2020

Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase

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12 December 2020

Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells.

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12 December 2020

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

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12 December 2020

Familial gastrointestinal stromal tumours with germline mutation of the KIT gene.

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12 December 2020

Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors

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12 December 2020

Bile reflux: a possible cause of stomach ulcer in nontreated mutant mice of W/WV genotype

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12 December 2020

Gastrointestinal stromal tumor: new nodule-within-a-mass pattern of recurrence after partial response to imatinib mesylate

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12 December 2020

Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor

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12 December 2020

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

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12 December 2020

Spontaneous stomach ulcer in genetically mast-cell depleted W/W v mice

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12 December 2020

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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12 December 2020

Necessity of bile for and lack of inhibitory effect of retinoid on development of forestomach papillomas in nontreated mutant mice of the W/Wv genotype

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12 December 2020

Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias.

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12 December 2020

10.1007/S00535-008-2200-Y

Identifiers

DOI

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19 August 2017

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PubMed ID

18648736