(Q37232738)

English

Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity

scientific article published on July 2000

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Statements

scholarly article

1 reference

Europe PubMed Central

19 August 2017

Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity (English)

1 reference

Europe PubMed Central

19 August 2017

0 references

author name string

Y Tsutsumi

1

1 reference

Europe PubMed Central

19 August 2017

M Onda

2

1 reference

Europe PubMed Central

19 August 2017

S Nagata

3

1 reference

Europe PubMed Central

19 August 2017

B Lee

4

1 reference

Europe PubMed Central

19 August 2017

R J Kreitman

5

1 reference

Europe PubMed Central

19 August 2017

I Pastan

6

1 reference

Europe PubMed Central

19 August 2017

language of work or name

0 references

publication date

1 July 2000

1 reference

Europe PubMed Central

19 August 2017

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

19 August 2017

97

1 reference

Europe PubMed Central

19 August 2017

8548-8553

1 reference

Europe PubMed Central

19 August 2017

15

1 reference

Europe PubMed Central

19 August 2017

Discovery of three genes specifically expressed in human prostate by expressed sequence tag database analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

6 September 2017

Molecular design of hybrid tumour necrosis factor alpha with polyethylene glycol increases its anti-tumour potency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

6 September 2017

Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

6 September 2017

Efficient site-directed mutagenesis using uracil-containing DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

6 September 2017

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

6 September 2017

IgG antibody response to polyethylene glycol-modified adenosine deaminase in patients with adenosine deaminase deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

6 September 2017

Sterically stabilized liposomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

6 September 2017

Ellman's reagent: 5,5′-dithiobis(2-nitrobenzoic acid)—a reexamination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

6 September 2017

Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

14 September 2017

Molecular design of hybrid tumour necrosis factor-alpha. II: The molecular size of polyethylene glycol-modified tumour necrosis factor-alpha affects its anti-tumour potency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

14 September 2017

Targeting Pseudomonas exotoxin to hematologic malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

28 September 2017

Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

28 September 2017

Targeted therapy of cancer with recombinant immunotoxins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

26 June 2018

Surface characteristics and the interaction of colloidal particles with mouse peritoneal macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

26 June 2018

Polyethylene glycol modification of the monoclonal antibody A7 enhances its tumor localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

26 June 2018

Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

26 June 2018

Polyethylene glycol-modified chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

3 September 2018

Pseudomonas exotoxin A mutants. Replacement of surface-exposed residues in domain III with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26985

3 September 2018

Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-PE38 at doses tolerated by cynomolgus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/10890891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatotoxicity in cancer patients receiving erb-38, a recombinant immunotoxin that targets the erbB2 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10890891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Responses in refractory hairy cell leukemia to a recombinant immunotoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/10890891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of the nonspecific animal toxicity of anti-Tac(Fv)-PE38 by mutations in the framework regions of the Fv which lower the isoelectric point

1 reference

https://pubmed.ncbi.nlm.nih.gov/10890891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preparation of a polyethylene glycol: superoxide dismutase adduct, and an examination of its blood circulation life and anti-inflammatory activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10890891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10890891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/10890891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment

1 reference

https://pubmed.ncbi.nlm.nih.gov/10890891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted delivery and improved therapeutic potential of catalase by chemical modification: combination with superoxide dismutase derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/10890891

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.140210597

1 reference

Europe PubMed Central

19 August 2017

2000PNAS...97.8548T

0 references

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

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0 references

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