(Q37264246)

19 August 2017

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title

Trends in large-scale mouse mutagenesis: from genetics to functional genomics (English)

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19 August 2017

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Yoichi Gondo

1

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19 August 2017

publication date

1 October 2008

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19 August 2017

published in

Nature Reviews Genetics

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19 August 2017

volume

9

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19 August 2017

issue

10

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19 August 2017

page(s)

803-810

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ARTIFICIAL TRANSMUTATION OF THE GENE

19 August 2017

cites work

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Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse

31 March 2020

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Dose--response curve for ethylnitrosourea-induced specific-locus mutations in mouse spermatogonia

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Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia

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Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes

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Altering the genome by homologous recombination

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Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

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A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

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Forward and reverse genetic approaches to behavior in the mouse

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A Mouse for All Reasons

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Initial sequencing and analysis of the human genome

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The Sequence of the Human Genome

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Chromosome engineering in mice

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Functional genetic analysis of mouse chromosome 11

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Survival of mouse embryos frozen to -196 degrees and -269 degrees C

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Cryopreservation of mouse spermatozoa

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Initial sequencing and comparative analysis of the mouse genome

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The mutagenic action of N-ethyl-N-nitrosourea in the mouse

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A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

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Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior

31 March 2020

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Positional cloning of the mouse circadian clock gene

31 March 2020

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Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

31 March 2020

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Saturation mutagenesis for dominant eye morphological defects in the mouse Mus musculus

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Screening for dysmorphological abnormalities—a powerful tool to isolate new mouse mutants

31 March 2020

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Identification of immunological relevant phenotypes in ENU mutagenized mice

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Enzyme-activity mutants in Mus musculus. I. Phenotypic description and genetic characterization of ethylnitrosourea-induced mutations

31 March 2020

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A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program

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Establishing an ENU mutagenesis screen for the piebald region of mouse Chromosome 14.

31 March 2020

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Sequence complexity of nuclear RNAs in adult rat tissues

31 March 2020

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The knockout mouse project

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The European dimension for the mouse genome mutagenesis program

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A reliable lacZ expression reporter cassette for multipurpose, knockout-first alleles

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Genomewide production of multipurpose alleles for the functional analysis of the mouse genome

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Site- and time-specific gene targeting in the mouse

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PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice

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Sleeping beauty: a novel cancer gene discovery tool

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Sequence-based analysis of mutagenized mice

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A gene-driven approach to the identification of ENU mutants in the mouse

31 March 2020

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A gene-driven ENU-based approach to generating an allelic series in any gene

31 March 2020

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Efficient and fast targeted production of murine models based on ENU mutagenesis

31 March 2020

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Molecular characterization of ENU mouse mutagenesis and archives

31 March 2020

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Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice

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Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis

31 March 2020

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A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse

31 March 2020

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A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy

31 March 2020

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A sequence-based variation map of 8.27 million SNPs in inbred mouse strains

31 March 2020

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Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.

31 March 2020

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Analysing complex genetic traits with chromosome substitution strains

31 March 2020

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Hybrid breakdown caused by substitution of the X chromosome between two mouse subspecies

31 March 2020

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The Collaborative Cross, a community resource for the genetic analysis of complex traits

31 March 2020

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Psychiatric genetics: progress amid controversy

31 March 2020

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Behavioral phenotypes of Disc1 missense mutations in mice

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG2431

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19 August 2017

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