(Q37276056)

2 July 2019

review article

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title

Statins in endothelial signaling and activation (English)

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2 July 2019

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Jeffrey R Jacobson

1

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2 July 2019

publication date

1 April 2009

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2 July 2019

Antioxidants & Redox Signaling

published in

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2 July 2019

volume

11

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2 July 2019

issue

4

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2 July 2019

page(s)

811-821

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2 July 2019

Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis

cites work

1 reference

12 December 2020

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

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12 December 2020

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

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12 December 2020

Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts

1 reference

12 December 2020

Effects of chronic treatment with simvastatin on endothelial dysfunction in spontaneously hypertensive rats

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12 December 2020

Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men

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12 December 2020

Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation

1 reference

12 December 2020

HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells

1 reference

12 December 2020

A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall

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12 December 2020

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

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12 December 2020

Direct interaction of actin with p47(phox) of neutrophil NADPH oxidase

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12 December 2020

Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription.

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12 December 2020

Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance

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12 December 2020

Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase.

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12 December 2020

Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity.

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12 December 2020

Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex

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12 December 2020

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

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12 December 2020

The effect of statins on mortality in patients with bacteremia

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12 December 2020

Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins.

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12 December 2020

Rapid effects on vascular function after initiation and withdrawal of atorvastatin in healthy, normocholesterolemic men.

1 reference

12 December 2020

Differential NADPH- versus NADH-dependent superoxide production by phagocyte-type endothelial cell NADPH oxidase

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12 December 2020

Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice

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12 December 2020

Cerivastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase, inhibits endothelial cell proliferation induced by angiogenic factors in vitro and angiogenesis in in vivo models

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12 December 2020

Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways

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12 December 2020

Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta

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12 December 2020

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA.

1 reference

12 December 2020

Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators

1 reference

12 December 2020

In vivo lipid-derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS.

1 reference

12 December 2020

Rho GTPases in cell biology

1 reference

12 December 2020

HMG-CoA reductase inhibitors promote cholesterol-dependent Akt/PKB translocation to membrane domains in endothelial cells

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12 December 2020

Pitavastatin-induced thrombomodulin expression by endothelial cells acts via inhibition of small G proteins of the Rho family

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12 December 2020

Effects of simvastatin on endothelial function after chronic inhibition of nitric oxide synthase by L-NAME.

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12 December 2020

Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation

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12 December 2020

HMG CoA reductase inhibitor suppresses the expression of tissue factor and plasminogen activator inhibitor-1 induced by angiotensin II in cultured rat aortic endothelial cells

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12 December 2020

Positional Control of Cell Fate Through Joint Integrin/Receptor Protein Kinase Signaling

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12 December 2020

Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin

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12 December 2020

Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase.

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12 December 2020

Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol

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12 December 2020

Superoxide anion overproduction in sepsis: effects of vitamin e and simvastatin.

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12 December 2020

p47(phox) PX domain of NADPH oxidase targets cell membrane via moesin-mediated association with the actin cytoskeleton

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12 December 2020

Protein kinase C phosphorylates caldesmon77 and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers

1 reference

12 December 2020

Prior statin therapy is associated with a decreased rate of severe sepsis

1 reference

12 December 2020

Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase

1 reference

12 December 2020

Pharmacologic treatments for acute respiratory distress syndrome and acute lung injury: systematic review and meta-analysis

1 reference

12 December 2020

p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II.

1 reference

12 December 2020

Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury

1 reference

12 December 2020

Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation

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12 December 2020

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

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12 December 2020

The effect of prior statin use on 30-day mortality for patients hospitalized with community-acquired pneumonia.

1 reference

12 December 2020

Mechanisms of statin-mediated inhibition of small G-protein function

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12 December 2020

Effect of statin use within the first 24 hours of admission for acute myocardial infarction on early morbidity and mortality

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12 December 2020

Statin therapy is associated with fewer deaths in patients with bacteraemia

1 reference

12 December 2020

Statin use and mortality within 180 days after bacteremia: A population-based cohort study*

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12 December 2020

Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.

1 reference

12 December 2020

Statins blunt thrombin-induced down-regulation of endothelial nitric oxide synthase expression in human endothelial cells

1 reference

12 December 2020

Endothelial Protection, AT1 Blockade and Cholesterol-Dependent Oxidative Stress: The EPAS Trial

1 reference

12 December 2020

Caldesmon is a cytoskeletal target for PKC in endothelium

1 reference

12 December 2020

Endothelial cell barrier enhancement by ATP is mediated by the small GTPase Rac and cortactin

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12 December 2020

Atorvastatin inhibits angiotensin II-induced T-type Ca2+ channel expression in endothelial cells

1 reference

12 December 2020

Pravastatin induces thrombomodulin expression in TNFalpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity

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12 December 2020

Vascular functions of the plasminogen activation system

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12 December 2020

Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin

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12 December 2020

Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase

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12 December 2020

Statin treatment and 3' polyadenylation of eNOS mRNA.

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12 December 2020

Geranylgeranylation but not GTP loading determines rho migratory function in T cells.

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12 December 2020

Effects of torcetrapib in patients at high risk for coronary events

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12 December 2020

Adverse balance of nitric oxide/peroxynitrite in the dysfunctional endothelium can be reversed by statins

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12 December 2020

Statins for infection and sepsis: a systematic review of the clinical evidence

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12 December 2020

Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression

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12 December 2020

Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition

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12 December 2020

Regulation of the mevalonate pathway

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12 December 2020

Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain

1 reference

12 December 2020

Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries

1 reference

12 December 2020

Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid.

1 reference

12 December 2020

The West of Scotland Coronary Prevention Study: a trial of cholesterol reduction in Scottish men.

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12 December 2020

Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface

1 reference

12 December 2020

Effect of simvastatin on coronary atheroma: the Multicentre Anti-Atheroma Study (MAAS)

1 reference

12 December 2020

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1 reference

12 December 2020

Hypercholesterolemia increases endothelial superoxide anion production

1 reference

12 December 2020

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

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12 December 2020

Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung

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12 December 2020

Protein prenylation: molecular mechanisms and functional consequences

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12 December 2020

Expression of phagocyte NADPH oxidase components in human endothelial cells

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12 December 2020

Regulation of tissue factor initiated thrombin generation by the stoichiometric inhibitors tissue factor pathway inhibitor, antithrombin-III, and heparin cofactor-II

1 reference

12 December 2020

Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid

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12 December 2020

Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors

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12 December 2020

Dynamic activation of endothelial nitric oxide synthase by Hsp90.

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12 December 2020

Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase

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12 December 2020

Nitric oxide synthase expression in endothelial cells exposed to mechanical forces

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12 December 2020

Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase

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12 December 2020

Identifiers

DOI

10.1089/ARS.2008.2284

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2 July 2019

PMCID

6463996

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2 July 2019

PubMed ID

18808324

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2 July 2019