(Q37280748)

19 August 2017

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title

Androgen synthesis in adrenarche (English)

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19 August 2017

Walter L Miller

1

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19 August 2017

1 March 2009

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Reviews in Endocrine and Metabolic Disorders

19 August 2017

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19 August 2017

10

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19 August 2017

1

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19 August 2017

3-17

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https://scigraph.springernature.com/pub.10.1007/s11154-008-9102-4

19 August 2017

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cites work

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11154-008-9102-4

Molecular cloning of a novel widely expressed human 80 kDa 17 beta-hydroxysteroid dehydrogenase IV

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11154-008-9102-4

Immunocytochemical localization of type 5 17beta-hydroxysteroid dehydrogenase in human reproductive tissues

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11154-008-9102-4

Estrogen: consequences and implications of human mutations in synthesis and action

21 January 2018

1 reference

12 December 2020

DHEA in elderly women and DHEA or testosterone in elderly men.

1 reference

12 December 2020

Molecular biology of steroid hormone synthesis

1 reference

12 December 2020

Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of A C21 steroid side-chain cleavage system (17 alpha-hydroxylase-C17,20 lyase)

1 reference

12 December 2020

Structural analysis of the gene encoding human 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase

1 reference

12 December 2020

Cholesterol side-chain cleavage, cytochrome P450, and the control of steroidogenesis

1 reference

12 December 2020

Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome p450scc and 3beta-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal [...]

1 reference

12 December 2020

Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency

1 reference

12 December 2020

Androgen therapy in women: an Endocrine Society Clinical Practice guideline.

1 reference

12 December 2020

Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis

1 reference

12 December 2020

Assignment of the gene for adrenal P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase) to human chromosome 10.

1 reference

12 December 2020

The regulation of 17,20 lyase activity

1 reference

12 December 2020

Cloning and expression of steroid sulfatase cDNA and the frequent occurrence of deletions in STS deficiency: implications for X-Y interchange

1 reference

12 December 2020

Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads

1 reference

12 December 2020

Peroxisomal D-hydroxyacyl-CoA dehydrogenase deficiency: resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency

1 reference

12 December 2020

Minireview: regulation of steroidogenesis by electron transfer

1 reference

12 December 2020

Steroid 17,20-desmolase deficiency: a new cause of male pseudohermaphroditism

1 reference

12 December 2020

Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+

1 reference

12 December 2020

Structure and lipid transport mechanism of a StAR-related domain

1 reference

12 December 2020

Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen----q25 are expressed in steroidogenic tissues

1 reference

12 December 2020

Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and the cholesterol side-chain-cleavage enzyme, P450scc [corrected], in human steroidogenic tissues

1 reference

12 December 2020

Gene structure, intracellular localization, and functional roles of sterol carrier protein-2.

1 reference

12 December 2020

Hormonal regulation of messenger ribonucleic acids for P450scc (cholesterol side-chain cleavage enzyme) and P450c17 (17 alpha-hydroxylase/17,20-lyase) in cultured human fetal adrenal cells

1 reference

12 December 2020

Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis

1 reference

12 December 2020

Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria

1 reference

12 December 2020

Acute ACTH regulation of adrenal corticosteroid biosynthesis. Rapid accumulation of a phosphoprotein

1 reference

12 December 2020

Rapid regulation of steroidogenesis by mitochondrial protein import

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12 December 2020

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12 December 2020

Medroxyprogesterone acetate and dexamethasone are competitive inhibitors of different human steroidogenic enzymes

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12 December 2020

Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis

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12 December 2020

GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1

1 reference

12 December 2020

Intracellular cholesterol transport

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12 December 2020

Porcine 80-kDa protein reveals intrinsic 17 beta-hydroxysteroid dehydrogenase, fatty acyl-CoA-hydratase/dehydrogenase, and sterol transfer activities

1 reference

12 December 2020

Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression

1 reference

12 December 2020

The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6

1 reference

12 December 2020

Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries

1 reference

12 December 2020

The primate adrenal zona reticularis is defined by expression of cytochrome b5, 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17) and NADPH-cytochrome P450 reductase (reductase) but not 3beta-hydroxysteroid dehydrogenase/...

1 reference

12 December 2020

Dehydroepiandrosterone replacement in women with adrenal insufficiency.

1 reference

12 December 2020

Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases

1 reference

12 December 2020

Sulfonation and molecular action

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12 December 2020

Exaggerated adrenarche and hyperinsulinism in adolescent girls born small for gestational age.

1 reference

12 December 2020

Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.

1 reference

12 December 2020

The longitudinal study of adrenal maturation during gonadal suppression: evidence that adrenarche is a gradual process

1 reference

12 December 2020

Regulation of cytochrome b5 gene transcription by Sp3, GATA-6, and steroidogenic factor 1 in human adrenal NCI-H295A cells

1 reference

12 December 2020

Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13

1 reference

12 December 2020

The active form of the steroidogenic acute regulatory protein, StAR, appears to be a molten globule

1 reference

12 December 2020

Pathways leading to phosphorylation of p450c17 and to the posttranslational regulation of androgen biosynthesis

1 reference

12 December 2020

Mechanisms for cellular cholesterol transport: defects and human disease

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12 December 2020

Congenital adrenal hyperplasia.

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12 December 2020

Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta

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12 December 2020

A pH-dependent molten globule transition is required for activity of the steroidogenic acute regulatory protein, StAR.

1 reference

12 December 2020

Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis

1 reference

12 December 2020

Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.

1 reference

12 December 2020

Replacement of dehydroepiandrosterone in adrenal failure: no benefit for subjective health status and sexuality in a 9-month, randomized, parallel group clinical trial

1 reference

12 December 2020

Evidence for dissociation between adrenarche and gonadarche: studies in patients with idiopathic precocious puberty, gonadal dysgenesis, isolated gonadotropin deficiency, and constitutionally delayed growth and adolescence

1 reference

12 December 2020

Missense mutation serine106—-proline causes 17 alpha-hydroxylase deficiency

1 reference

12 December 2020

Immunohistochemical study of cytochrome b5 in human adrenal gland and in adrenocortical adenomas from patients with Cushing's syndrome.

1 reference

12 December 2020

Localization of the human CYP17 gene (cytochrome P450(17 alpha)) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding

1 reference

12 December 2020

Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism

1 reference

12 December 2020

Adrenarche results from development of a 3beta-hydroxysteroid dehydrogenase-deficient adrenal reticularis

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12 December 2020

Decrease in the expression of the 3beta-hydroxysteroid dehydrogenase gene in human adrenal tissue during prepuberty and early puberty: implications for the mechanism of adrenarche.

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12 December 2020

17beta-hydroxysteroid dehydrogenases: physiological roles in health and disease.

1 reference

12 December 2020

Hyperinsulinemia in postpubertal girls with a history of premature pubarche and functional ovarian hyperandrogenism.

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12 December 2020

Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry

1 reference

12 December 2020

The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology

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12 December 2020

Identification of positive and negative placenta-specific basal elements and a cyclic adenosine 3',5'-monophosphate response element in the human gene for P450scc

1 reference

12 December 2020

The genetic and functional basis of isolated 17,20-lyase deficiency

1 reference

12 December 2020

Human Proopiomelanocortin-(79–96), a Proposed Cortical Androgen- Stimulating Hormone, Does not Affect Steroidogenesis in Cultured Human Adult Adrenal Cells*

1 reference

12 December 2020

Dehydroepiandrosterone and androsterone levels in human plasma: effect of age and sex; day-to-day and diurnal variations

1 reference

12 December 2020

Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase

1 reference

12 December 2020

Structure of the human steroidogenic acute regulatory protein (StAR) gene: StAR stimulates mitochondrial cholesterol 27-hydroxylase activity.

1 reference

12 December 2020

Human NADPH-P450 oxidoreductase: complementary DNA cloning, sequence and vaccinia virus-mediated expression and localization of the CYPOR gene to chromosome 7.

1 reference

12 December 2020

Minireview: cellular redox state regulates hydroxysteroid dehydrogenase activity and intracellular hormone potency

1 reference

12 December 2020

Enzymology of human cytosolic sulfotransferases

1 reference

12 December 2020

Defects of cholesterol biosynthesis

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12 December 2020

Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue

1 reference

12 December 2020

StAR search--what we know about how the steroidogenic acute regulatory protein mediates mitochondrial cholesterol import

1 reference

12 December 2020

Molecular endocrinology of hydroxysteroid dehydrogenases

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12 December 2020

Role of electron transport in the regulation of the lyase activity of C21 side-chain cleavage P-450 from porcine adrenal and testicular microsomes

1 reference

12 December 2020

Expression of steroid sulfatase during embryogenesis.

1 reference

12 December 2020

Regulation of steroid hormone biosynthesis. Identification of precursors of a phosphoprotein targeted to the mitochondrion in stimulated rat adrenal cortex cells

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12 December 2020

Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution

1 reference

12 December 2020

Steroid deficiency syndromes in mice with targeted disruption of Cyp11a1.

1 reference

12 December 2020

Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood

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12 December 2020

Molecular evolution of adrenarche: structural and functional analysis of p450c17 from four primate species

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12 December 2020

The pathophysiology and genetics of congenital lipoid adrenal hyperplasia.

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12 December 2020

Non-vesicular sterol transport in cells

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12 December 2020

Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21

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12 December 2020

Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17

1 reference

12 December 2020

Steroidogenic activity of StAR requires contact with mitochondrial VDAC1 and phosphate carrier protein.

1 reference

12 December 2020

Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development

1 reference

12 December 2020

Human adrenodoxin: cloning of three cDNAs and cycloheximide enhancement in JEG-3 cells

1 reference

12 December 2020

Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase

1 reference

12 December 2020

Cholesterol binding does not predict activity of the steroidogenic acute regulatory protein, StAR.

1 reference

12 December 2020

Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase

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12 December 2020

Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes

1 reference

12 December 2020

Isolation and sequencing of a complementary deoxyribonucleic acid clone encoding human placental 17 beta-estradiol dehydrogenase: identification of the putative cofactor binding site

1 reference

12 December 2020

Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells

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12 December 2020

Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial

1 reference

12 December 2020

Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells

1 reference

12 December 2020

17Beta-hydroxysteroid dehydrogenase types 1 and 2 in human placenta: an immunohistochemical study with correlation to placental development

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12 December 2020

Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis

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12 December 2020

Steroid disorders in children: congenital adrenal hyperplasia and apparent mineralocorticoid excess

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12 December 2020

Human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase from placenta: expression in nonsteroidogenic cells of a protein that catalyzes the dehydrogenation/isomerization of C21 and C19 steroids

1 reference

12 December 2020

Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17

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12 December 2020

Inherited congenital adrenal hyperplasia in the rabbit is caused by a deletion in the gene encoding cytochrome P450 cholesterol side-chain cleavage enzyme

1 reference

12 December 2020

NF-1C, Sp1, and Sp3 are essential for transcription of the human gene for P450c17 (steroid 17alpha-hydroxylase/17,20 lyase) in human adrenal NCI-H295A cells

1 reference

12 December 2020

Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues

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12 December 2020

StAR-like activity and molten globule behavior of StARD6, a male germ-line protein.

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12 December 2020

Low expression of 3 beta-hydroxy-5-ene steroid dehydrogenase gene in human fetal adrenals in vivo; adrenocorticotropin and protein kinase C-dependent regulation in adrenocortical cultures

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12 December 2020

The 30-kDa mitochondrial proteins induced by hormone stimulation in MA-10 mouse Leydig tumor cells are processed from larger precursors.

1 reference

12 December 2020

Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism

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12 December 2020

The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)

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12 December 2020

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain

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12 December 2020

Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases

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12 December 2020

Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution

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12 December 2020

Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA.

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12 December 2020

Type 5 17beta-hydroxysteroid dehydrogenase: its role in the formation of androgens in women

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12 December 2020

The Sequence of the Human Genome

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12 December 2020

In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development

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12 December 2020

Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase

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12 December 2020

Expression of the putative sterol binding protein Stard6 gene is male germ cell specific

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12 December 2020

Mitochondrial 3 beta-hydroxysteroid dehydrogenase (HSD) is essential for the synthesis of progesterone by corpora lutea: an hypothesis

1 reference

12 December 2020

A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom).

1 reference

12 December 2020

Pharmacogenetics of human cytosolic sulfotransferases

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12 December 2020

The control of steroidogenesis by human fetal adrenal cells in tissue culture. IV. The effect of exposure to placental steroids

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12 December 2020

Isolation and characterization of pig kidney mitochondrial ferredoxin:NADP+ oxidoreductase

1 reference

12 December 2020

Decreased insulin sensitivity in prepubertal girls with premature adrenarche and acanthosis nigricans.

1 reference

12 December 2020

Human Proopiomelanocortin-(79–96), a Proposed Androgen Stimulatory Hormone, Does not Affect Steroidogenesis in Cultured Human Fetal Adrenal Cells*

1 reference

12 December 2020

Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

1 reference

12 December 2020

Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal

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12 December 2020

Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer

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12 December 2020

Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice

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12 December 2020

The molecular genetics of 21-hydroxylase deficiency

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12 December 2020

C21 steroid side chain cleavage enzyme from porcine adrenal microsomes. Purification and characterization of the 17 alpha-hydroxylase/C17,20-lyase cytochrome P-450

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12 December 2020

cAMP post-transcriptionally diminishes the abundance of adrenodoxin reductase mRNA

1 reference

12 December 2020

Disorders of steroid 11 beta-hydroxylase isozymes

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12 December 2020

Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells

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12 December 2020

Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes

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12 December 2020

P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5.

1 reference

12 December 2020

Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function

1 reference

12 December 2020

Cytochrome P450: what have we learned and what are the future issues?

1 reference

12 December 2020

Hormonal regulation of P450scc (20,22-desmolase) and P450c17 (17 alpha-hydroxylase/17,20-lyase) in cultured human granulosa cells

1 reference

12 December 2020

Serum cortisol, dehydroepiandrosterone sulfate, and steroid-binding globulins in preterm neonates: effect of gestational age and dexamethasone therapy.

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12 December 2020

Molecular genetics and pathophysiology of 17 beta-hydroxysteroid dehydrogenase 3 deficiency

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12 December 2020

Regulation of the acute production of steroids in steroidogenic cells

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12 December 2020

Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome

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12 December 2020

Regulation of the gene for estrogenic 17-ketosteroid reductase lying on chromosome 17cen----q25

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12 December 2020

Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3

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12 December 2020

The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human adrenal cortex resulting from its low expression of 3 beta-hydroxysteroid dehydrogenase.

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12 December 2020

Initial sequencing and analysis of the human genome

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12 December 2020

Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress

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12 December 2020

10.1007/S11154-008-9102-4

Identifiers

DOI

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19 August 2017

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PubMed ID

18821018