(Q37293344)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18853343%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

review article

1 reference

title

Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18853343%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

0 references

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18853343%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

author name string

Sergio A Jimenez

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18853343%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

publication date

1 January 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18853343%20AND%20SRC:MED&resulttype=core&format=json

International Reviews of Immunology

15 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18853343%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

volume

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18853343%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18853343%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

page(s)

351-374

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18853343%20AND%20SRC:MED&resulttype=core&format=json

Evolving concepts of rheumatoid arthritis

15 January 2020

cites work

1 reference

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Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets

21 January 2018

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Signal transduction and transcription factors in rheumatic disease

21 January 2018

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NF-kappaB regulation in the immune system

21 January 2018

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NF-kappaB signaling pathways in mammalian and insect innate immunity

21 January 2018

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Missing pieces in the NF-kappaB puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Shared principles in NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Quantitative prediction of NF-kappa B DNA-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

IkappaB kinases: key regulators of the NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Anti-inflammatory interventions of NF-kappaB signaling: potential applications and risks

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Escherichia coli prevents phagocytosis-induced death of macrophages via classical NF-kappaB signaling, a link to T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

NF-kappaB and the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

The Role of relB in Regulating the Adaptive Immune Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

The transcriptional program of terminal granulocytic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Network communications: lymphotoxins, LIGHT, and TNF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Increased synovial tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

RANK is essential for osteoclast and lymph node development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Nuclear factor-kappa B activity in T cells from patients with rheumatic diseases: a preliminary report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Macrophage-derived cytokine and nuclear factor kappaB p65 expression in synovial membrane and skin of patients with psoriatic arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expr

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Signaling events involved in macrophage chemokine expression in response to monosodium urate crystals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Monosodium urate crystals synergize with IFN-gamma to generate macrophage nitric oxide: involvement of extracellular signal-regulated kinase 1/2 and NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Molecular mechanism of basic calcium phosphate crystal-induced activation of human fibroblasts. Role of nuclear factor kappab, activator protein 1, and protein kinase c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Impact of transcription factors AP-1 and NF-kappaB on the outcome of experimental Staphylococcus aureus arthritis and sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-kappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Effect of hypoxia and reoxygenation on gene expression and response to interleukin-1 in cultured articular chondrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Biomechanical signals inhibit IKK activity to attenuate NF-kappaB transcription activity in inflamed chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Protein kinase C alpha and zeta regulate nitric oxide-induced NF-kappa B activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Transcriptional activation by NF-kappaB requires multiple coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-kappa B transcriptional activity in models of rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

The NF-kappaB pathway as a potential target for autoimmune disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Therapeutic strategies for rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Proteasome inhibition: a new anti-inflammatory strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Regulation of synovial cell apoptosis by proteasome inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor kappaB decoy oligodeoxynucleotides as a gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Protein transduction: identification, characterization and optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Amelioration of arthritis by intraarticular dominant negative Ikk beta gene therapy using adeno-associated virus type 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Reduced infiltration and increased apoptosis of leukocytes at sites of inflammation by systemic administration of a membrane-permeable IkappaBalpha repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Effect of a small molecule inhibitor of nuclear factor-kappaB nuclear translocation in a murine model of arthritis and cultured human synovial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

NF-kappaB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Morpholino oligos: making sense of antisense?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Gene silencing in mammals by small interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Defining and assaying RNAi in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaBp65-specific siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180802295740